{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:24:33Z","timestamp":1767626673935,"version":"3.37.3"},"reference-count":103,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010232","name":"National Institute of Development Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000349","name":"National Institute for Academic Anaesthesia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2020,4,10]]},"DOI":"10.1021\/acsptsci.0c00017","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T15:03:46Z","timestamp":1584543826000},"page":"190-202","source":"Crossref","is-referenced-by-count":8,"title":["Peptide-Liganded G Protein-Coupled Receptors as Neurotherapeutics"],"prefix":"10.1021","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-944X","authenticated-orcid":true,"given":"Lee E.","family":"Eiden","sequence":"first","affiliation":[{"name":"Section on Molecular Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Ann","family":"Goosens","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine, Mt. Sinai Hospital, New York, New York 10029, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-1493","authenticated-orcid":true,"given":"Kenneth A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism\/National Institute on Drug Abuse, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Autonomous University of Mexico (UNAM), Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.56"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29797"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.098764"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.023"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.09.001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14075"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612353113"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003278"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12837"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12538"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jo202105v"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002271107"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00012-4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb17489.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2015.03.010"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.131"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12735"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00292"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1211"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1197"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.029"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0124-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.03.019"},{"issue":"6437","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1126\/science.aav3932","volume":"364","author":"Allen W. E.","year":"2019","journal-title":"Science"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2013.10.014"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0027-0"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010716-104511"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.31164"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1902-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1118-P"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nature22800"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12618"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00318"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.06.016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06958.x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00185-7"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.040"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.12.038"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.06.020"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.11.061"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00017"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901046R"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2953"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.052"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.01.012"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0386-8"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0280-2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111902"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.245415"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:7:1-2:003"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.1"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.03.005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00048"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2647"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1037\/a0034028"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523629113"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15392"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nature13978"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.09.023"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14087"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00163"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.135"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0135-5"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.03.008"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.02.001"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97233"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.055"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.02.008"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212323"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64379-4"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00196"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.10.010"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00092"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0099-5"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00919"},{"key":"ref80\/cit80","first-page":"17","volume":"11","author":"Schlessinger J.","year":"2005","journal-title":"Scientist"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706900104"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112915"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.033"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10539.2002"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23263"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.47"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300360"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0313-z"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.27"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14101"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.01.001"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.08.085"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1983"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.10.001"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.11.5.603"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.03.003"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21127"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1702492"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby055"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404175101"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-013-9644-8"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.6.1256"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.0c00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T22:11:53Z","timestamp":1681769513000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.0c00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4,10]]}},"alternative-id":["10.1021\/acsptsci.0c00017"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.0c00017","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"type":"print","value":"2575-9108"},{"type":"electronic","value":"2575-9108"}],"subject":[],"published":{"date-parts":[[2020,3,18]]}}}