{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:48:15Z","timestamp":1786740495492,"version":"build-2736575974"},"reference-count":7,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traditionally, vertebrate models have been utilized and are viewed as more pertinent; however, we propose the application of an invertebrate model such as locusts to study human disease and sickness behavior at an early phase of research. This model has numerous benefits, namely, expense, swiftness, procedural convenience, and ethical acceptance. For example, the injection of immunogen-induced anorexia behavior in rats and locusts in vivo are analogous. Moreover, the presence of a brain barrier in locusts reveals remarkable similarities in molecular methods utilized by E. coli K1 to traverse the central nervous system of rats and locusts, consequently providing a worthwhile model to investigate pathogenesis. The presence of cytokines in these insects and presence of a brain barrier (which is physiologically relevant to human blood\u2013brain barrier) makes it a relevant model in determining disease mechanisms and invasion of the brain by central nervous system pathogens.<\/jats:p>","DOI":"10.1021\/acsptsci.0c00151","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T16:37:42Z","timestamp":1602175062000},"page":"1423-1424","source":"Crossref","is-referenced-by-count":2,"title":["Locusts: A Model to Investigate Human Disease and\nSickness Behavior"],"prefix":"10.1021","volume":"3","author":[{"given":"Ruqaiyyah","family":"Siddiqui","sequence":"first","affiliation":[{"name":"American University of Sharjah , , PO Box 26666, , ,","place":["University City, Sharjah, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7667-8553","authenticated-orcid":true,"given":"Naveed Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"American University of Sharjah , , PO Box 26666, , ,","place":["University City, Sharjah, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"2026081416173664300_cit1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.peptides.2015.09.011","article-title":"Identification\nand functional characterization of a novel locust peptide belonging\nto the family of insect growth blocking peptides","volume":"74","author":"Duressa","year":"2015","journal-title":"Peptides"},{"key":"2026081416173664300_cit2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0924-977X(02)00059-7","article-title":"Effect\nof 5-HT in mianserin-pretreated rats on the structure of feeding behavior","volume":"12","author":"Mancilla-Diaz","year":"2002","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2026081416173664300_cit3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4161\/viru.17631","article-title":"Next generation\nof non-mammalian blood-brain barrier models to study parasitic infections\nof the central nervous system","volume":"3","author":"Siddiqui","year":"2012","journal-title":"Virulence"},{"key":"2026081416173664300_cit4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.pt.2010.08.003","article-title":"Non-vertebrate models\nto study parasite invasion of the central nervous system","volume":"27","author":"Siddiqui","year":"2011","journal-title":"Trends Parasitol."},{"key":"2026081416173664300_cit5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cell.2005.09.017","article-title":"The blood-brain barrier--lessons\nfrom moody flies","volume":"123","author":"Daneman","year":"2005","journal-title":"Cell"},{"key":"2026081416173664300_cit6","doi-asserted-by":"publisher","first-page":"5735","DOI":"10.1128\/IAI.00740-07","article-title":"Novel model\nto study virulence determinants of Escherichia coli K1","volume":"75","author":"Khan","year":"2007","journal-title":"Infect. Immun."},{"key":"2026081416173664300_cit7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1099\/jmm.0.47568-0","article-title":"Development of a novel ex\nvivo insect model for studying virulence determinants of Escherichia coli K1","volume":"57","author":"Mokri-Moayyed","year":"2008","journal-title":"J. Med. Microbiol."}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.0c00151","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/3\/6\/1423\/6275082\/pt0c00151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/3\/6\/1423\/6275082\/pt0c00151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:17:42Z","timestamp":1786738662000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article\/3\/6\/1423\/611945\/Locusts-A-Model-to-Investigate-Human-Disease-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,10,8]]},"published-print":{"date-parts":[[2020,12,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acsptsci.0c00151","relation":{},"ISSN":["2575-9108"],"issn-type":[{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]}}}