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Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Curcumin, extracted from the golden spice turmeric, is a well-known natural polyphenol that has been extensively studied for its broad pleiotropic attributes and its ability to modulate multiple biological processes. It is well-documented to target pro-inflammatory mediators like NF-\u03baB, ROS, COX-2, IL-1, IL-2, TGF-\u03b2, growth factors, apoptotic proteins, receptors, and various kinases. These properties make curcumin a promising nutraceutical in the treatment of many oral diseases like oral submucous fibrosis, oral mucositis, oral leukoplakia, oral erythroplakia, oral candidiasis, aphthous stomatitis, oral lichen planus, dental caries, periodontitis, and gingivitis. Numerous in vitro and in vivo studies have shown that curcumin alleviates the symptoms of most of the oral complications, including the inhibition of the progression of oral cancer. In this regard, many clinical trials have been completed, and many are ongoing to investigate the \u201ccurcumin effect\u201d in oral maladies. Therefore, the current review delineates the mechanistic framework of curcumin\u2019s propensity in curbing oral diseases and present outcomes of the clinical trials of curcumin-based therapeutics that can provide a breakthrough in the clinical management of these diseases.<\/jats:p>","DOI":"10.1021\/acsptsci.1c00017","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T18:17:26Z","timestamp":1616005046000},"page":"647-665","source":"Crossref","is-referenced-by-count":39,"title":["From Simple Mouth Cavities to Complex Oral Mucosal\nDisorders\ue5f8Curcuminoids as a Promising Therapeutic Approach"],"prefix":"10.1021","volume":"4","author":[{"given":"Sosmitha","family":"Girisa","sequence":"first","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviral","family":"Kumar","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Rana","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dey","family":"Parama","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzini Devi","family":"Daimary","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"King\u2019s College London and WHO Collaborating Centre for Oral Cancer and Precancer , , ,","place":["London, United Kingdom, WC2R 2LS"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Prem","family":"Kumar","sequence":"additional","affiliation":[{"name":"National University of Singapore , , ,","place":["Singapore, Singapore, 117600"]},{"name":"National University of Singapore , , ,","place":["Singapore, Singapore, 117600"]},{"name":"National University Health Systems , , ,","place":["Singapore, Singapore, 117600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-6816","authenticated-orcid":true,"given":"Ajaikumar B.","family":"Kunnumakkara","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (IIT) Guwahati , , , ,","place":["Guwahati, Assam, India, 781039"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"2026081904082977300_cit1","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.31557\/APJCP.2019.20.11.3437","article-title":"An Investigation on the Therapeutic\nPotential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous\nCell Carcinoma","volume":"20","author":"Bordoloi","year":"2019","journal-title":"Asian Pac. 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