{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:34:49Z","timestamp":1788212089120,"version":"build-2803163510"},"reference-count":102,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2023,7,14]]},"DOI":"10.1021\/acsptsci.3c00052","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T18:25:48Z","timestamp":1688149548000},"page":"970-981","source":"Crossref","is-referenced-by-count":13,"title":["Determination of the Potential Clinical Benefits of Small Molecule Factor XIa Inhibitors in Arterial Thrombosis"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-7055","authenticated-orcid":true,"given":"Surasak","family":"Wichaiyo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"},{"name":"Centre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warisara","family":"Parichatikanond","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"},{"name":"Centre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsawat","family":"Visansirikul","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakkawee","family":"Saengklub","sequence":"additional","affiliation":[{"name":"Centre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"},{"name":"Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipharak","family":"Rattanavipanon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.5045\/br.2021.2020083"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001830"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2021.05.002"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1315-2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017559"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2014.1.66"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.903029"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216314"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-02-900480"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062353"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9120437"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1177\/0269216318815377"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15126"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.904003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38875.675486.55"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-04-0246"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.11.051"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309846"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01128.x"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000193624.28251.83"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12921"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437772"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00385"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-718114"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312130"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0792-9"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.14740\/jh522"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12540"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10746"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/hgv.2017.43"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1191944"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1735971"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2047286"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00019"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315099"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt343"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.307034"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.187393"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.195412"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.001"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12162"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.10.010"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304114"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.038733"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81268-7"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13235"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-12-0920"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-792580"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895866"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306954"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15236"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017004879"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac544.2924"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052458"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01236.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303209"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050664"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01973.x"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1309\/QC259F09UNMKVP0R"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15092"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943738"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.09.015"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742262"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-120139"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.05.016"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.02.009"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-023697"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00656.x"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/med.21503"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.306925"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01768"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00613"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15700"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15439"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15230"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00456-1"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061612"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01588-4"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.821363"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02130"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14732"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12012"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13520"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12524"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1258-7"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.043"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0599-0"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15588"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13148"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-022-01150-1"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-022-00266-6"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25936-2"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-022-01110-9"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2113194"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106742"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1027627"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01171"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313141"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211027003"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00052","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T08:13:40Z","timestamp":1689322420000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.3c00052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":102,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,14]]}},"alternative-id":["10.1021\/acsptsci.3c00052"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.3c00052","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}