{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:17:03Z","timestamp":1788308223879,"version":"build-2803163510"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2019721"],"award-info":[{"award-number":["BE2019721"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SKYD2023171"],"award-info":[{"award-number":["SKYD2023171"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2022078"],"award-info":[{"award-number":["Z2022078"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Fund of the Dantu District","award":["GY2021001"],"award-info":[{"award-number":["GY2021001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2023,12,8]]},"DOI":"10.1021\/acsptsci.3c00210","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T14:28:25Z","timestamp":1699367305000},"page":"1909-1923","source":"Crossref","is-referenced-by-count":22,"title":["Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes"],"prefix":"10.1021","volume":"6","author":[{"given":"Baofei","family":"Yan","sequence":"first","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"School of Pharmacy, Jiangsu Health Vocational College, Nanjing 211800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215399, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Huai\u2019an Hospital of Xuzhou Medical University, The Second People\u2019s Hospital of Huai\u2019an, Huai\u2019an 223002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Ji\u2019nan 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sipan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinai","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengtao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-6787","authenticated-orcid":true,"given":"Tingming","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050774"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.007"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104686"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.031"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020191"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.02.006"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101086"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.10.036"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6056948"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.217"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2174\/187221110791184999"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM02161G"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.120036"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.008"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.05.003"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0269-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.08.025"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115999"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101720"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.06.023"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.11.017"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15952"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116111"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3109\/03639040903325560"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1103-6_16"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084156"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00507-z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.078"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4049-x"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.200"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04765-1"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3458"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-09950-5"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1284"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224846"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/md17080455"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nature13568"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319664"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0628-3"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1851"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00047-22"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02211"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00033"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00979-1"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115365"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00210","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:16:10Z","timestamp":1702026970000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.3c00210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,8]]}},"alternative-id":["10.1021\/acsptsci.3c00210"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.3c00210","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]}}}