{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:53:50Z","timestamp":1780469630063,"version":"3.54.1"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31DA054760"],"award-info":[{"award-number":["F31DA054760"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UG3DA048386"],"award-info":[{"award-number":["UG3DA048386"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,2,9]]},"DOI":"10.1021\/acsptsci.3c00228","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T13:28:01Z","timestamp":1703251681000},"page":"363-374","source":"Crossref","is-referenced-by-count":8,"title":["Multivalent Vaccination Strategies Protect against Exposure to Polydrug Opioid and Stimulant Mixtures in Mice and Rats"],"prefix":"10.1021","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5193-0861","authenticated-orcid":true,"given":"Daihyun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-2465","authenticated-orcid":true,"given":"Bethany","family":"Crouse","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"},{"name":"School of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Vigliaturo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah M.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"},{"name":"School of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagny","family":"Heimisdottir","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Kassick","sequence":"additional","affiliation":[{"name":"Neuroscience Disruptive Research Lab, Allegheny Health Network Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadyah E.","family":"Averick","sequence":"additional","affiliation":[{"name":"Neuroscience Disruptive Research Lab, Allegheny Health Network Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States"},{"name":"Neuroscience Institute, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Raleigh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pravetoni","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, United States"},{"name":"University of Washington Center for Medication Development for Substance Use Disorders; Garvey Institute for Brain Solutions, Seattle,Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref1\/cit1","unstructured":"Centers\nfor Disease Control and\nPrevention. U.S. Overdose Deaths In 2021 Increased Half as Much as\nin 2020 \u2013 But Are Still Up 15%, May 11 2022. https:\/\/www.cdc.gov\/nchs\/pressroom\/nchs_press_releases\/2022\/202205.htm (accessed 2023\u201302\u201327)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6935a1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9479612.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1103900405"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh180"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen094"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-540-33823-9_2","volume-title":"Analgesia","volume":"177","author":"Z\u00f6llner C.","year":"2006"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0156"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0897-z"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.258566"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.265561"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.06.001"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/252708a0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.189506"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.281"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-420118-7.00014-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.101"},{"key":"ref18\/cit18","unstructured":"Centers for\nDisease Control and\nPrevention. Pneumococcal Vaccination, Jan 23, 2023. https:\/\/www.cdc.gov\/pneumococcal\/vaccination.html (accessed 2023\u201302\u201327)."},{"key":"ref19\/cit19","unstructured":"Centers for Disease Control and\nPrevention. Quadrivalent Influenza Vaccine, Aug 25 2023. https:\/\/www.cdc.gov\/flu\/prevent\/quadrivalent.htm (accessed 2023\u201310\u201312)."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666090-00008"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1212785"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.253674"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00260"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.201194"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00697-9"},{"key":"ref26\/cit26","volume-title":"UM Researchers Prep Fentanyl, Heroin Vaccines for Human Trials","author":"Shimek C.","year":"2023"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.3c00347"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00694-y"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.051"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00079"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00179"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.15.100"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.01.047"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2174\/187152711799219316"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07502.x"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.03.044"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01042"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00592"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-00247-7"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.10.033"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(89)90157-6"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.3.400"},{"key":"ref43\/cit43","unstructured":"Centers for\nDisease Control and\nPrevention. Fentanyl Facts, Sep 6, 2023. https:\/\/www.cdc.gov\/stopoverdose\/fentanyl\/index.html (accessed 2023\u201310\u201312)."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.811208"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/mp400631w"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096547"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00933"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00228","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T17:43:08Z","timestamp":1707759788000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.3c00228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,9]]}},"alternative-id":["10.1021\/acsptsci.3c00228"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.3c00228","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]}}}