{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:26:38Z","timestamp":1790807198204,"version":"4.1.0"},"reference-count":269,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,1,12]]},"DOI":"10.1021\/acsptsci.3c00324","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T13:15:45Z","timestamp":1704201345000},"page":"72-96","source":"Crossref","is-referenced-by-count":18,"title":["Emerging Landscape of Osteogenesis Imperfecta Pathogenesis and Therapeutic Approaches"],"prefix":"10.1021","volume":"7","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"PET Center, Chongqing University Three Gorges Hospital, Chongqing 404000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"PET Center, Chongqing University Three Gorges Hospital, Chongqing 404000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School of Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Liu","sequence":"additional","affiliation":[{"name":"PET Center, Chongqing University Three Gorges Hospital, Chongqing 404000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-8788","authenticated-orcid":true,"given":"Hu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.101"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.20.00171"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0299"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00165"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1963"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000117"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.52"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.1.30"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.9.1650"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2208"},{"issue":"3","key":"ref11\/cit11","first-page":"508","volume":"51","author":"Willing M.","year":"1992","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"ref12\/cit12","first-page":"359","volume":"23","author":"Chen C.","year":"2012","journal-title":"Genetic Counseling (Geneva, Switzerland)"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1159\/000494491"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.4317\/jced.58263"},{"issue":"7","key":"ref15\/cit15","first-page":"1358","volume":"125","author":"Feng Z.","year":"2012","journal-title":"Chin. Med. J."},{"key":"ref16\/cit16","volume-title":"Endotext","author":"Marini J. C.","year":"2000"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06581-x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4540"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-023-01065-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0201-z"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1334"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.166"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1505"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.717294"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4448-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.02.022"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107594"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.01.031"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.05.016"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22731"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21647"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.11"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101142"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.115"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.07.012"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-154"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2021-107942"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.021"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00946.x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.014"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4277"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62664"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab017"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010429"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22677"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.08.010"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36545"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00728-X"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20429"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.06.011"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-015-0667-1"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101307"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184568"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123992"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252684"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/ng1968"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp481"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr037"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00897"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2776"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63488"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.01.023"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.02.019"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu608"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.01.034"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00612"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600074113"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02302-2"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022269"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4549"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246554"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00622-5"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257254"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006156"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aad9055"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.05.028"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22274"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008012"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40347"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.02.010"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215458"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61119"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.08.008"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00045-X"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.5.1335"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01361-4"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.823"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz017"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1177\/10406387221081227"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90234-8"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1625"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7039"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11920"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.662751"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03596.x"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw222"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.09.009"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.10.053"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2859"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4011"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.3390\/children8060512"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.3390\/genes13101880"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.131"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1007\/BF00297295"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10174"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.12.111"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb55328.x"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10124"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116516"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516637045"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2019.05.004"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05799-x"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61464"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200309000-00004"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31826bf19b"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60979-3"},{"issue":"2","key":"ref119\/cit119","first-page":"171","volume":"15","author":"Pouliot-Laforte A.","year":"2015","journal-title":"J. Musculoskeletal Neuronal Interact."},{"issue":"2","key":"ref120\/cit120","first-page":"1","volume":"17","author":"Veilleux L.","year":"2017","journal-title":"J. Musculoskeletal Neuronal Interact."},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2518"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0335"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3732"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0319-3"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114857"},{"issue":"4","key":"ref126\/cit126","first-page":"B5454","volume":"65","author":"Folkestad L.","year":"2018","journal-title":"Danish Med. J."},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2895"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1151870"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02643-3"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02535-y"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds183"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2018.36"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00313.2019"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63007"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2010.05.007"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2018.02.010"},{"issue":"4","key":"ref137\/cit137","first-page":"294","volume":"49","author":"Ichikawa H.","year":"1996","journal-title":"Kyobu Geka: Jpn. J. Thorac. Surg."},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1004946"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.06.001"},{"issue":"4","key":"ref140\/cit140","first-page":"588","volume":"15","author":"Khashu M.","year":"2006","journal-title":"J. Heart Valve Dis."},{"issue":"5","key":"ref141\/cit141","first-page":"513","volume":"23","author":"Karamifar H.","year":"2013","journal-title":"Iran. J. Pediatr."},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2015.15.04.003"},{"key":"ref143\/cit143","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/B978-0-12-397165-4.00031-9","volume-title":"Osteogenesis Imperfecta","author":"Chau F. Y.","year":"2014"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00721-3"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1080\/13816810500228993"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2015.11.005"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0495-y"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14882"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116249"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.1.14"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2002.00062.x"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035438"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.81"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33909"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3709-1"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.032"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000223557.54670.aa"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01404-w"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e31821bfb50"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-021-00665-z"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200002060-00005"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10118"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.06.011"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70074-X"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391402"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000236"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2410"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0145-1"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30138-9"},{"issue":"1","key":"ref170\/cit170","first-page":"24","volume":"16","author":"Hoyer-Kuhn H.","year":"2016","journal-title":"J. Musculoskeletal Neuronal Interact."},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2004.17.1.829022"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1695"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.207"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.2.237"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1932"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3312"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4221fje"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708322"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00042"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3143"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.04.011"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2737-y"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115121"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000813"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3544"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00170"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00103"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01800"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.04.001"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16191"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00488"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.066"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6651075"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01199"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119628"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4501"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.03.001"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1433"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.038521"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.02.002"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx171"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000656"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00594-3"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4611"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1227"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000159029.48678.93"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.265"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.385"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-105809"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195859"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.040"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195859"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3432"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0504-3"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2010.04.008"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2632959100"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-315069"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.124800"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X09666140923101914"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1089\/107632700300003323"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4987"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0383"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mju004"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2003.700602.x"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.07.019"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2013.2104"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.07.018"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00105"},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.03.001"},{"key":"ref232\/cit232","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-014-2440-9"},{"key":"ref233\/cit233","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0186"},{"key":"ref234\/cit234","doi-asserted-by":"publisher","DOI":"10.1002\/stem.108"},{"issue":"1","key":"ref235\/cit235","first-page":"36","volume":"61","author":"Ardeshirylajimi A.","year":"2015","journal-title":"Cell. Mol. Biology (Noisy-le-Grand, France)"},{"key":"ref236\/cit236","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101622"},{"key":"ref237\/cit237","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.002"},{"key":"ref238\/cit238","doi-asserted-by":"publisher","DOI":"10.1038\/nature25164"},{"key":"ref239\/cit239","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101449"},{"key":"ref240\/cit240","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10461"},{"key":"ref241\/cit241","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143141"},{"key":"ref242\/cit242","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-021-00248-8"},{"key":"ref243\/cit243","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5774"},{"key":"ref244\/cit244","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.198"},{"key":"ref245\/cit245","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300339"},{"key":"ref246\/cit246","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2020.100028"},{"key":"ref247\/cit247","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.20.4013"},{"key":"ref248\/cit248","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6298"},{"key":"ref249\/cit249","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3451"},{"key":"ref250\/cit250","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4326"},{"key":"ref251\/cit251","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300839"},{"key":"ref252\/cit252","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110235"},{"key":"ref253\/cit253","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00229"},{"key":"ref254\/cit254","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2030430"},{"key":"ref255\/cit255","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020217"},{"key":"ref256\/cit256","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27826"},{"key":"ref257\/cit257","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27392"},{"key":"ref258\/cit258","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2018.1517750"},{"key":"ref259\/cit259","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2004.10.1456"},{"key":"ref260\/cit260","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105215"},{"key":"ref261\/cit261","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0336"},{"key":"ref262\/cit262","doi-asserted-by":"publisher","DOI":"10.3390\/genes14030730"},{"key":"ref263\/cit263","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27556-w"},{"key":"ref264\/cit264","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21479-8"},{"key":"ref265\/cit265","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0344"},{"key":"ref266\/cit266","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.841778"},{"key":"ref267\/cit267","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0410-7"},{"key":"ref268\/cit268","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.10.007"},{"key":"ref269\/cit269","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.02.011"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00324","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.3c00324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:42:31Z","timestamp":1705052551000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.3c00324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":269,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,12]]}},"alternative-id":["10.1021\/acsptsci.3c00324"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.3c00324","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]}}}