{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:46:43Z","timestamp":1782888403400,"version":"3.54.5"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f?r Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2180 - 390900677"],"award-info":[{"award-number":["EXC 2180 - 390900677"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"Ministerium f?r Wissenschaft, Forschung und Kunst Baden-W?rttemberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,12,13]]},"DOI":"10.1021\/acsptsci.4c00189","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:01:57Z","timestamp":1730815317000},"page":"3827-3845","source":"Crossref","is-referenced-by-count":1,"title":["A Defined Diet Combined with Sonicated Inoculum Provides a High Incidence, Moderate Severity Form of Experimental Autoimmune Encephalomyelitis (EAE)"],"prefix":"10.1021","volume":"7","author":[{"given":"Mariella","family":"Martorelli","sequence":"first","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"},{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Eberhard Karls University T\u00fcbingen, Auf der Morgenstelle 8, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dengler","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Laux","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"},{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Eberhard Karls University T\u00fcbingen, Auf der Morgenstelle 8, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Fischer","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne","family":"Vaiceliunaite","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Hahn","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Cruces","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pokoj","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"de Oliveira da Cunha","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wohlbold","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-4650","authenticated-orcid":true,"given":"Pierre","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universit\u00e4tsstra\u00dfe 31, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-1486","authenticated-orcid":true,"given":"Stefan","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Eberhard Karls University T\u00fcbingen, Auf der Morgenstelle 8, 72076 T\u00fcbingen, Germany"},{"name":"Cluster of Excellence iFIT (EXC 2180) \u201cImage-Guided and Functionally Instructed Tumor Therapies\u201d, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"T\u00fcbingen Center for Academic Drug Discovery & Development (T\u00fcCAD2), 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-5441","authenticated-orcid":true,"given":"Michael","family":"Burnet","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Maier","sequence":"additional","affiliation":[{"name":"Synovo GmbH, Paul-Ehrlich-Stra\u00dfe 15, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref1\/cit1","unstructured":"Harrison\u2019s Principles\nof Internal Medicine, 21e | AccessMedicine | McGraw Hill Medical. https:\/\/accessmedicine.mhmedical.com\/book.aspx?bookId=3095 (accessed\nApril 2023)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/ni1507"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.147"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52001-2.00002-9"},{"key":"ref6\/cit6","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Fauci A. S.","year":"2015"},{"key":"ref7\/cit7","volume-title":"Current Diagnosis & Treatment Neurology","author":"Brust J. C. M.","year":"2018"},{"issue":"10","key":"ref8\/cit8","first-page":"1935","volume":"70","author":"Calabresi P. A.","year":"2004","journal-title":"Am. Fam Phys."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"issue":"3","key":"ref10\/cit10","first-page":"175","volume":"37","author":"Goldenberg M. M.","year":"2012","journal-title":"P T"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00675-0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646485"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000096"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.07.008"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-017-0772-0"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0123"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1501s88"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00510.2016"},{"issue":"1","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4049\/jimmunol.146.1.101","volume":"146","author":"Whitham R. H.","year":"1991","journal-title":"J. Immunol."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004150"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11541"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901906"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2017.04.003"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173032"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-018-0236-z"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-13-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004768"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02913-w"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2016-001408"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.09.003"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.12.009"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2021.109443"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.07.010"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21716"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl075"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293487"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"ref39\/cit39","unstructured":"Tizard, I. R. Adjuvants and Adjuvanticity. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7348637\/ (accessed August 2024)."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/2091142b0"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28839-3"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.012"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6030069"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.09.140"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.889765"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1434-3"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-13-3"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1177\/1759091420962681"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13030311"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.039"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70117-6"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/JN\/131.2.568S"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0023-4"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.1.88"},{"key":"ref55\/cit55","unstructured":"T-bet or not T-bet:\nTaking\nthe last bow on the autoimmunity stage - Spath - 2013 - European Journal\nof Immunology - Wiley Online Library. https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/eji.201344109 (accessed December 2023)."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3505"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847540"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.004"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00189","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T09:12:05Z","timestamp":1734081125000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,13]]}},"alternative-id":["10.1021\/acsptsci.4c00189"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00189","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}