{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:11:28Z","timestamp":1773807088368,"version":"3.50.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZD2021CY001"],"award-info":[{"award-number":["ZD2021CY001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22071058"],"award-info":[{"award-number":["22071058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22173032"],"award-info":[{"award-number":["22173032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["33606043"],"award-info":[{"award-number":["33606043"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,10,11]]},"DOI":"10.1021\/acsptsci.4c00369","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T19:55:16Z","timestamp":1727898916000},"page":"3170-3191","source":"Crossref","is-referenced-by-count":3,"title":["Novel Alkynylamide-Based Nonpeptidic Allosteric Inhibitors for SARS-CoV-2 3-Chymotrypsin-like Protease"],"prefix":"10.1021","volume":"7","author":[{"given":"Jian","family":"Xue","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqi","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yexi","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuheng","family":"Song","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-3736","authenticated-orcid":true,"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-757X","authenticated-orcid":true,"given":"Shunying","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116263"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106080"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2020.08.025"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb4489"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.37"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01140"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2223-y"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.06.016"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00665"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016961"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01063"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00319"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00818"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89013-w"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085658"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26239-2"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4784"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01618-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42102-y"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114030"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00117"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1101\/2020.08.31.274639"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01146"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00108"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01482-9"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01359"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04677-5"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb4489"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/c5cc09918h"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03987"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO01409B"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05824"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201406853"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02761"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ja5107404"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ja9935207"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c01321"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.04.129"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128623"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1177\/1087057109336751"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105381"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7945"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0356-z"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c08060"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.15252\/embj.20105114"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00418-x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00975-5"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9517-8"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00369","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:12:23Z","timestamp":1728634343000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,11]]}},"alternative-id":["10.1021\/acsptsci.4c00369"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00369","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}