{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:43:30Z","timestamp":1792014210663,"version":"4.4.0"},"reference-count":114,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020373","name":"Central Council for Research in Homeopathy, Ministry of AYUSH, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,12,13]]},"DOI":"10.1021\/acsptsci.4c00400","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T20:21:40Z","timestamp":1727209300000},"page":"3645-3657","source":"Crossref","is-referenced-by-count":27,"title":["Neprilysin-Mediated Amyloid Beta Clearance and Its Therapeutic Implications in Neurodegenerative Disorders"],"prefix":"10.1021","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4185","authenticated-orcid":true,"given":"Shailendra K.","family":"Saxena","sequence":"first","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"},{"name":"The World Society for Virology (WSV), Northampton, Massachusetts 01060, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saniya","family":"Ansari","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"},{"name":"The World Society for Virology (WSV), Northampton, Massachusetts 01060, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"},{"name":"The World Society for Virology (WSV), Northampton, Massachusetts 01060, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swatantra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"},{"name":"The World Society for Virology (WSV), Northampton, Massachusetts 01060, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Sharma","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep S.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneham","family":"Tiwari","sequence":"additional","affiliation":[{"name":"F. M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhitij","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, King George\u2019s Medical University, Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz T.","family":"Paweska","sequence":"additional","affiliation":[{"name":"The World Society for Virology (WSV), Northampton, Massachusetts 01060, United States"},{"name":"Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Private Bag X4, Sandringham, Johannesburg 2131, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdel-Moneim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Taif University, Al-Taif 21944 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soniya","family":"Nityanand","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine, King George\u2019s Medical University (KGMU), Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-022-03123-4"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.04.001"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051709"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30299-5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"ref7\/cit7","unstructured":"World failing to address dementia challenge. World Health\nOrganization, September 2, 2021. https:\/\/www.who.int\/news\/item\/02-09-2021-world-failing-to-address-dementia-challenge (accessed 2024-09-02)."},{"key":"ref8\/cit8","unstructured":"Dementia. World\nHealth Organization, March 15, 2023. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia (accessed 2024-03-14)."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.04160"},{"key":"ref10\/cit10","unstructured":"Neurological\ndisorders affect millions globally: WHO report. World Health\nOrganization, February 27, 2007. https:\/\/www.who.int\/news\/item\/27-02-2007-neurological-disorders-affect-millions-globallywhoreport (accessed 2024-03-14)."},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952161"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1159\/000351153"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.776523"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29228"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210215"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009399"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57078"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.290881"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2012.20.3.245"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bi902134p"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-020-02240-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059946"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.49.32730"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00098"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102270"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070620"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/72237"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1042\/bj1370477"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111363"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.3.301"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.008"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008511200"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.03.072"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666141218140953"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01132-2"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.05.010"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.160945"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81165-z"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1042\/bj2150519"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602487200"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(95)00021-B"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84580-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90020-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2018.06.004"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182345e46"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1155\/JBB\/2006\/58406"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90201-6"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210209"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/bi00191a006"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/359322a0"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/jm040773o"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/bi972979f"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2000.4288"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb19935.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100816"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.735"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90458-8"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168979"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-0468-6"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402248200"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00125-4"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt211"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2017.1290679"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2000-23-408"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00077"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12675"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111571200"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0230450100"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.048090"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.210"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02393-05"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/nm1206"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64041826.x"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-62"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.370924"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.222"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9644-x"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b22-00833"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18089949"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2008.10.008"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52309-z"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832617"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401891200"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a003040"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-017-0234-5"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12602"},{"issue":"5","key":"ref93\/cit93","first-page":"9","volume":"2","author":"Prasad Joshi Y.","year":"2016","journal-title":"Int. J. Sci. Res. Sci., Eng. Technol."},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.124"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v12.i8.787"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4792-03.2004"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.003"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-01992.2003"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710509200"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070105"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00898-X"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601372200"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00787-6"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040262"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.649646"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-109"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1038\/srep01472"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03008-6"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001666"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122410"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.4719"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.10.010"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181afe475"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1159\/000500811"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00400","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T09:12:01Z","timestamp":1734081121000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":114,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,13]]}},"alternative-id":["10.1021\/acsptsci.4c00400"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00400","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}