{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:13:59Z","timestamp":1792206839984,"version":"4.4.0"},"reference-count":119,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["DDR\/IIRP23\/3052"],"award-info":[{"award-number":["DDR\/IIRP23\/3052"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2024,10,11]]},"DOI":"10.1021\/acsptsci.4c00430","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T01:29:07Z","timestamp":1725931747000},"page":"2971-2986","source":"Crossref","is-referenced-by-count":9,"title":["Innovative Approaches and Future Directions in the Management and Understanding of Varicose Veins: A Systematic Review"],"prefix":"10.1021","volume":"7","author":[{"given":"Aaqib","family":"Javaid","sequence":"first","affiliation":[{"name":"Infectious Disease Biology Laboratory, Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abutwaibe","family":"KA","sequence":"additional","affiliation":[{"name":"Infectious Disease Biology Laboratory, Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherilraj","family":"PM","sequence":"additional","affiliation":[{"name":"Infectious Disease Biology Laboratory, Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Arora","sequence":"additional","affiliation":[{"name":"Infectious Disease Biology Laboratory, Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-0616","authenticated-orcid":true,"given":"Shyam Lal","family":"Mudavath","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Life Sciences, University of Hyderabad, Prof. C.R. Rao Road, Gachibowli Hyderabad, Telangana 500046, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/1755738017704473"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.08.007"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.10.009"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s13221-014-0024-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810204"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2022.08.1009"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004631"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(18)31203-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-016-0465-y"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/538627"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0323"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035584"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2011.01409.x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00110.x"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-0795-8_1"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033357"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2018.230"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100106"},{"issue":"1","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000331970005100101","volume":"27","author":"Nicolaides A. N.","year":"2008","journal-title":"Int. Angiol."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000103067.10695.74"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513491724"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2004.34.7.655"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.110349"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.10.014"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.11.014"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.03.006"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.4324\/9780203081297"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1177\/1538574413477216"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001732.pub3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S294990"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.20340\/vmi-rvz.2022.1.CLIN.9"},{"issue":"8","key":"ref32\/cit32","first-page":"1","volume":"21","author":"Ontario Health (Quality)","year":"2021","journal-title":"Ont. Health Technol. Assess. Ser."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-021-03044-1"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2012.02.013"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1177\/0268355515593186"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9612"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1177\/0268355516632438"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","unstructured":"Lanzer, P. PanVascular Medicine, 2nd ed. 2015; pp 1\u20135004","DOI":"10.1007\/978-3-642-37078-6"},{"issue":"1","key":"ref39\/cit39","first-page":"59","volume":"12","author":"Spiridon M.","year":"2017","journal-title":"Maedica"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7562.287"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.003"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100023"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921948"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2017.11.002"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.202200513"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1177\/02683555231162294"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-021-00783-z"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/538627"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2019-001075"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10301"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1159\/000100375"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122534"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01023.x"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704849"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5164576"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.04.008"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312920200"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63013-8"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180716104159"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111336"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1159\/000106189"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.003"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.10.041"},{"key":"ref64\/cit64","author":"Boisseau M. R.","year":"2007","journal-title":"Phlebolymphology"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1177\/0003319703054001S03"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X20947789"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6548-9_2"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1177\/00033197050560i103"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1177\/1076029616645330"},{"key":"ref70\/cit70","author":"Buj\u00e1n J.","year":"2008","journal-title":"Phlebolymphology"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9258396"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-322"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.7150\/IJMS.54052"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2022.05.010"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.e126"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006898"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1177\/154431670603000103"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3095-6_4"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011023"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0163416"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200802062"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513477023"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X221092817"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.01.079"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2011.054"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.107094"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.08.004"},{"key":"ref88\/cit88","first-page":"2007","volume":"124","year":"2009","journal-title":"Public Health Rep."},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1692395"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1126208"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00904-4"},{"key":"ref92\/cit92","author":"Yao P. Y.","year":"2023","journal-title":"StatPearls"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.10.016"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2021.05.010"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.49770"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.05.093"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-020-04705-0"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.2174\/157016109788340758"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L204"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2023.104.5.288"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1177\/030006057800600216"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1308\/003588403321219858"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1002\/9781118067178.ch3"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.11.006"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2003.00840.x"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.3310\/hta17480"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.02.008"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.04.013"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2021.08.011"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2014.09.007"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S294990"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2022.05.010"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.3389\/fnano.2020.589541"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5653-9"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c04649"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_490_20"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-022-04977-8"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-02812-y"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2023.132889"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00430","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:12:36Z","timestamp":1728634356000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":119,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,11]]}},"alternative-id":["10.1021\/acsptsci.4c00430"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00430","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]}}}