{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:43:35Z","timestamp":1769831015863,"version":"3.49.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 5558\/1-1"],"award-info":[{"award-number":["KA 5558\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["200069\/2024-1"],"award-info":[{"award-number":["200069\/2024-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["88887.911426\/2023-00"],"award-info":[{"award-number":["88887.911426\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,1,10]]},"DOI":"10.1021\/acsptsci.4c00515","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T20:47:46Z","timestamp":1733950066000},"page":"146-172","source":"Crossref","is-referenced-by-count":2,"title":["Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties"],"prefix":"10.1021","volume":"8","author":[{"given":"Lukas","family":"Imberg","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena I.","family":"Siutkina","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Erbacher","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius F.","family":"Broekmans","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzanna A.","family":"Ovsepyan","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-3673","authenticated-orcid":true,"given":"Constantin G.","family":"Daniliuc","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Gon\u00e7alves de Oliveira","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States"},{"name":"Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateus S\u00e1 Magalh\u00e3es","family":"Serafim","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States"},{"name":"Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-8896","authenticated-orcid":true,"given":"Thanigaimalai","family":"Pillaiyar","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical\/Medicinal Chemistry, Eberhard Karls University T\u00fcbingen, 72076 T\u00fcbingen, Germany"},{"name":"T\u00fcbingen Center for Academic Drug Discovery (T\u00fcCAD2), 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail A.","family":"Panteleev","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 119991 Moscow, Russia"},{"name":"Laboratory of Translational Medicine, Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, 117997 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-4204","authenticated-orcid":true,"given":"Antti","family":"Poso","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland"},{"name":"Department of Internal Medicine VIII, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-8213","authenticated-orcid":true,"given":"Svetlana A.","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Institute of Food Chemistry, University of M\u00fcnster, M\u00fcnster 48149, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-3282","authenticated-orcid":true,"given":"Marcel","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Nekipelov","sequence":"additional","affiliation":[{"name":"Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-7201","authenticated-orcid":true,"given":"Gerd","family":"Bendas","sequence":"additional","affiliation":[{"name":"Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-6787","authenticated-orcid":true,"given":"Uwe","family":"Karst","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-5364","authenticated-orcid":true,"given":"Dmitrii V.","family":"Kalinin","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Medicinal Chemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1160\/th14-08-0671"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219881"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150006"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.1_Supplement.10S"},{"key":"ref6\/cit6","unstructured":"Hannah, R.; Spooner, F.; Roser, M. Our World in Data. 2019. https:\/\/ourworldindata.org\/causes-of-death. (accessed Oct 26, 2022)."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12947"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew214"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15126"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0674"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00018"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.15.2369"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.8.857"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-10-0807"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306925"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709043371007"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.64S"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1098-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.018"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2020.01.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1268866"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2016.1154045"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112753"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1945580"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2022.2026926"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.04.020"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201377"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01635"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00204"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3235"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100431"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ph15111340"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503132"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.06.016"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005590"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112753"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2445"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1517\/17460441003605098"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02081"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3287"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.12.005"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976195part1552"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.08.014"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.01.017"},{"key":"ref45\/cit45","unstructured":"Bruker\nAXS APEX4 Version 2021.4-0, SAINT\nVersion 8.40B\nand SADABS Bruker AXS Area Detector Scaling and Absorption Correction\nVersion 2016\/2; Bruker AXS Inc.: Madison, Wisconsin, USA, 2021."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229614024218"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00875"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01494"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00065"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00693"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20718-8"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3549"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.10.011"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.11.009"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.04.032"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1039\/c5md00414d"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00200"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200388"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600366"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c00765"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0897"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1468"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/ci049885e"},{"key":"ref65\/cit65","unstructured":"Deposition\nnumber 2378670 (for 13d) contains the supplementary crystallographic\ndata for this paper. These data are provided free of charge by the\njoint Cambridge Crystallographic Data Centre and Fachinformationszentrum\nKarlsruhe Access Structures service via: www.ccdc.cam.ac.uk\/data_request\/cif."}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00515","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T09:12:39Z","timestamp":1736500359000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,10]]}},"alternative-id":["10.1021\/acsptsci.4c00515"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00515","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}