{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:50:39Z","timestamp":1789203039705,"version":"build-2803163510"},"reference-count":199,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,7,11]]},"DOI":"10.1021\/acsptsci.4c00613","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T07:58:06Z","timestamp":1750233486000},"page":"1847-1866","source":"Crossref","is-referenced-by-count":2,"title":["Opiophobia: Misinformation, Misconceptions, Misrepresentations, Perspectives, and Consequences"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-7979","authenticated-orcid":true,"given":"John A.","family":"Bumpus","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Cedar Falls, United States"]},{"name":"University of Northern Iowa","place":["Cedar Falls, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2023.173616"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081634"},{"key":"ref3\/cit3","unstructured":"ERAS Society. https:\/\/erassociety.org\/ Accessed\n17 April 2025."},{"key":"ref4\/cit4","unstructured":"https:\/\/uihc.org\/educational-resources\/enhanced-recovery-after-surgery-eras Accessed 17 April 2025."},{"key":"ref5\/cit5","unstructured":"Enhanced recovery after\nsurgery (ERAS) A guide for patients having\ncolorectal surgery https:\/\/uihc.org\/educational-resources\/colorectal-surgery-patient-instructions Accessed 17 April 2025."},{"key":"ref6\/cit6","unstructured":"Lawhern, R. A. Doctors Prescribing to Their Patients Did Not Create the US Opioid Crisis. January 9. 2023.  American Council on Science and Health, 2023. https:\/\/www.acsh.org\/news\/2023\/01\/09\/doctors-prescribing-their-patients-did-not-create-us-opioid-crisis-16787#:~:text=Published%20data%20from%20the%20CDC%20and%20other%20sources,health%20crisis%20in%20addiction%20and%20death%20involving%20opioids (Accessed 4-17-2025)."},{"key":"ref7\/cit7","volume-title":"Decreased Opioid Prescribing Not a Silver Bullet For Reducing Overdose Deaths","author":"Starr M."},{"key":"ref8\/cit8","volume-title":"2023 Overdose Epidemic Report","author":"AMA","year":"2024"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S199750"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1080\/24740527.2017.1319733"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003572"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx048"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1507771"},{"key":"ref14\/cit14","volume-title":"Opioids for Pain Management","author":"IASP","year":"2012"},{"key":"ref15\/cit15","volume-title":"Drugs and Supplements Oxycodone and ibuprofen (oral route)","author":"Mayo Clinic","year":"2025"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.721357"},{"key":"ref17\/cit17","unstructured":"https:\/\/www.goldfinchhealth.com\/ (Accessed 17 April 2025)."},{"key":"ref18\/cit18","unstructured":"https:\/\/billionpillpledge.com\/ (Accessed 17 April 2025)."},{"key":"ref19\/cit19","volume-title":"OPINION: billion Pill Pledge could remove leftover opioids from our homes and communities","author":"Leyba M.","year":"2024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5790"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.3298"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.05.037"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pdig.0000075"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"ref25\/cit25","volume-title":"International statistical classification of diseases and related health problems ICD-10","author":"WHO","year":"2009"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7367"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.016"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1251"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2016.07.113"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01075"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0504"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.06.010"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005084"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1849"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1827"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.10.018"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-020-03486-4"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004967"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/10550880802122646"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199502000-00008"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0584-7"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788168100"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104800"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2023_448"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0117-2"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.09.020"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121803"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/life12020196"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1037\/a0022721"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00132"},{"key":"ref51\/cit51","volume-title":"Tramadol: A Missed Opportunity for the Treatment of Depression","author":"Bumpus J. A.","year":"2022"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14428"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.4172\/neuropsychiatry.1000327"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0451-3"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0284-1"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082410"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08725"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-198807000-00007"},{"key":"ref59\/cit59","unstructured":"https:\/\/www.statista.com\/chart\/32997\/share-of-us-respondents-diagnosed-with-depression\/ Accessed 17 May 2025."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2024.03.018"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004552"},{"key":"ref62\/cit62","unstructured":"https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db491.htm (Accessed 17 May 2025)."},{"key":"ref63\/cit63","unstructured":"https:\/\/media.market.us\/opioid-statistics\/ (Accessed 17 May 2025)."},{"key":"ref64\/cit64","volume-title":"Responding to the Opioid Epidemic","author":"Haslund-Gourley B.","year":"2022"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006461"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.03.074"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.53260\/grem.2450103"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9030333"},{"key":"ref69\/cit69","volume-title":"Multimodal Analgesia","author":"London Pain Clinic","year":"2024"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2165\/1158414-S0-000000000-00000"},{"key":"ref71\/cit71","unstructured":"Dhaliwal, A.; Gupta, M., Physiology, Opioid Receptor. In  StatPearls. StatPearls Publishing: Treasure Island, FL; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK546642\/ (Accessed 4-17-2025)."},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-57.2.67"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00079-2"},{"key":"ref75\/cit75","volume-title":"StatPearls","author":"Agrawal S.","year":"2024"},{"key":"ref76\/cit76","volume-title":"StatPearls","author":"Ghlichloo I.","year":"2024"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj9954"},{"key":"ref78\/cit78","unstructured":"https:\/\/www.ada.org\/resources\/ada-library\/oral-health-topics\/oral-analgesics-for-acute-dental-pain (Accessed 17 April 2025)."},{"issue":"2","key":"ref79\/cit79","first-page":"211","volume":"128","author":"Thomas Deahl S.","year":"2011","journal-title":"Tex. Dent. J."},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2018.02.012"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221139230"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127611"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2024.10.014"},{"key":"ref84\/cit84","unstructured":"https:\/\/www.painmedicinenews.com\/Clinical-Pain-Medicine\/Article\/01-25\/Study-OTC-Painkillers-More-Effective-Than-Opioids-for-Wisdom-Teeth-Removal\/76130 (Accessed 17 April 2025)."},{"key":"ref85\/cit85","unstructured":"https:\/\/plu.mx\/plum\/a\/news?doi=10.1016%2Fj.adaj.2024.10.014&theme=plum-sciencedirect-theme&hideUsage=true (Accessed 17 April 2025)."},{"key":"ref86\/cit86","volume-title":"Does Advil Plus Tylenol Relieve Pain Better than Vicodin? Read the Fine Print","author":"Bloom J.","year":"2025"},{"key":"ref87\/cit87","unstructured":"https:\/\/www.mayoclinic.org\/drugs-supplements\/hydrocodone-oral-route\/description\/drg-20084881 (Accessed 17 April 2025)."},{"key":"ref88\/cit88","unstructured":"https:\/\/www.drugs.com\/dosage\/vicodin.html (Accessed 17 April 2025)."},{"key":"ref89\/cit89","volume-title":"StatPearls","author":"Cofano S.","year":"2024"},{"key":"ref90\/cit90","volume-title":"Oral Opioids (Hydrocodone, Oxycodone, Hydromorphone, Morphine) Pain Management Education at UCSF","author":"University of California"},{"key":"ref91\/cit91","volume-title":"Peri-Operative Pain Management","author":"MD Anderson Cancer Center"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.9023"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.5419"},{"key":"ref94\/cit94","unstructured":"https:\/\/www.aapc.com\/codes\/icd-10-codes\/F11.20 (Accessed 17\nApril 2025)."},{"key":"ref95\/cit95","unstructured":"https:\/\/acdis.org\/articles\/qa-clarifying-inclusion-and-exclusion-notes (Accessed 17 April 2025)."},{"key":"ref96\/cit96","unstructured":"https:\/\/www.aapc.com\/codes\/icd-10-codes\/T40.0X. (Accessed 17 April 2025)."},{"key":"ref97\/cit97","unstructured":"https:\/\/www.aapc.com\/codes\/icd-10-codes\/F11.1 (Accessed 17 April 2025)."},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1186\/s13561-023-00465-4"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0207"},{"key":"ref100\/cit100","volume-title":"American Society of Anesthesiologists Annual Meeting","author":"Bertoch T.","year":"2024"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02744-2"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.3390\/ph17010029"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010007"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.13563"},{"key":"ref105\/cit105","volume-title":"Personalizing Pain Management for Women","author":"NIH HEAL Initiative"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0000000000000549"},{"key":"ref107\/cit107","volume-title":"U.S. Population 1950\u20132024","author":"Macrotrends LLC","year":"2024"},{"key":"ref108\/cit108","unstructured":"Dydyk, A. M.; Jain, N. K.; Gupta, M. Opioid Use Disorder. In  StatPearls StatPearls Publishing, Treasure Island, FL 2024."},{"key":"ref109\/cit109","volume-title":"BPP 2024 Annual Report (digital)"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.06.020"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.07.017"},{"key":"ref112\/cit112","volume-title":"ERAS Comes of Age With Opioid-Free Breast Cancer Surgery","author":"Helwick C.","year":"2020"},{"key":"ref113\/cit113","volume-title":"StatPearls","author":"Sadiq N. M.","year":"2024"},{"key":"ref114\/cit114","unstructured":"https:\/\/michigan-open.org\/prescribing-recommendations\/ (Accessed 17 April 2025)."},{"key":"ref115\/cit115","unstructured":"https:\/\/www.mdcalc.com\/calc\/10170\/morphine-milligram-equivalents-mme-calculator (Accessed 17 April 2025)."},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.09.011"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X162692"},{"key":"ref118\/cit118","first-page":"5","volume":"30","author":"Beeton A. G.","year":"1992","journal-title":"S Afr. J. Surg."},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000080153.36643.83"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2008.06.006"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3064-9"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13355"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13418"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2023.0251"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.3385"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2891"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.884674"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005680"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001075"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2024.2360128"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000724"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000721"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002966"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2493"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.860019"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1097\/PSN.0000000000000206"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199710000-00017"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.13.14"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6104383"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12751"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S144066"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1037\/ser0000099"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v11i12.4846"},{"key":"ref144\/cit144","volume-title":"Stop Making Surgeons Undertreat Postoperative Pain","author":"Singer J. A.","year":"2021"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000068822.10113.9E"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006605.pub2"},{"key":"ref147\/cit147","volume-title":"Waging a Counterattack on Opioids: First-dose Prevention Strategies for the Workplace & at Home","author":"Beyer C.","year":"2022"},{"key":"ref148\/cit148","volume-title":"Opioid Overdose Crisis","year":"2021"},{"key":"ref149\/cit149","volume-title":"Associations of nonmedical pain reliever use and initiation of heroin use in the United States","author":"Muhuri P. K.","year":"2013"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.366"},{"key":"ref151\/cit151","unstructured":"https:\/\/www.statista.com\/statistics\/476177\/number-of-individulas-starting-to-consume-heroin-us\/#statistic (Accessed 17 April 2025)."},{"key":"ref152\/cit152","volume-title":"Statista Number of annual opioid prescriptions in the U.S. from 2006 to 2023"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1508490"},{"key":"ref154\/cit154","unstructured":"https:\/\/www.thedoctorpatientforum.com\/ (Accessed 17 April 2025)."},{"key":"ref155\/cit155","volume-title":"Event Brochure. 1B:The Billion Pill Pledge: How Iowa is Modeling the Way Nationally for Opioid Prevention","author":"Newland B.","year":"2023"},{"key":"ref156\/cit156","volume-title":"Oskaloosa hospital is working to combat the opioid epidemic","author":"Searles D.","year":"2023"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.4167"},{"key":"ref158\/cit158","volume-title":"Study Shows America\u2019s Opioid Treatment Deserts","author":"Bicycle Health"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.5603\/ocp.96515"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200106000-00008"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-023-00585-0"},{"key":"ref162\/cit162","volume-title":"Daily Nurse: The Pulse of Nursing. How Nurses Can. Help Prevent Opioid Addiction","author":"Kinsella L.","year":"2017"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.370"},{"key":"ref164\/cit164","volume-title":"StatPearls","author":"Amaraneni A.","year":"2024"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563577"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13212"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000435447.96642.f4"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2015.12222919"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1080\/09687637.2020.1711871"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000223"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0831"},{"key":"ref172\/cit172","volume-title":"Modern Medicine. Americans are hoarding a \u2018massive\u2019 black market supply of opioids","author":"Mullaney T.","year":"2017"},{"key":"ref173\/cit173","unstructured":"Bloom, J.; Berezow, A. Why we are hoarding our opioid pills, STAT 2017 https:\/\/www.statnews.com\/2017\/01\/31\/opioid-pills-hoarding\/ (Accessed 17 April 2025)."},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-017-0112-7"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232538"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2021.113986"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2021.108651"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2022-0017"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3059"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109109"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.12.026"},{"key":"ref182\/cit182","volume-title":"84 FR 48170 - Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2020","author":"Office of the Federal Register, National Archives and Records Administration","year":"2019"},{"key":"ref183\/cit183","volume-title":"Feds Say Doctors Going Too Far Limiting Pain Pills","author":"Mills S.","year":"2019"},{"key":"ref186\/cit186","volume-title":"Iowa Drug Control Strategy & Drug Use Profile Annual Report February 9","author":"Iowa Drug Control Strategy","year":"2022"},{"key":"ref187\/cit187","volume-title":"Iowa Drug Control Strategy addresses substance abuse issues over next year","author":"Iowa Drug Control Strategy","year":"2022"},{"key":"ref188\/cit188","volume-title":"AMA\/IQVIA Institute: Opioid prescription trends by state 2012\u20132023","author":"AMA\/IQVIA Institute"},{"key":"ref189\/cit189","volume-title":"DEA overreach: A threat to doctor\u2019 freedom in American medicine","author":"Parker L. J.","year":"2024"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1080\/01947648.2022.2147366"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-022-00447-5"},{"key":"ref192\/cit192","volume-title":"Opioids can help reduce the amount of medication needed to achieve anesthesia","author":"Bicket M. C.","year":"2022"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S235366"},{"key":"ref194\/cit194","volume-title":"Pain patients say \u2018something is wrong\u2019 with Michigan\u2019s opioid laws","author":"Lyons C.","year":"2019"},{"key":"ref195\/cit195","volume-title":"\u2018They See a Cash Cow\u2019: Corporations Could Consume $50 Billion of Opioid Settlements","author":"Pattani A.","year":"2023"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S453155"},{"key":"ref197\/cit197","volume-title":"Controlled Substances Act","year":"1970"},{"key":"ref198\/cit198","unstructured":"McKenna, S. DEA Cuts in Opioid Supply \u2018Completely Irresponsible\u2019 Pain News Network 2023 https:\/\/www.painnewsnetwork.org\/stories\/2023\/12\/2\/dea-cuts-in-opioid-supply-completely-irresponsible (Accessed 17 April 2025)."},{"key":"ref199\/cit199","unstructured":"Mitri, L. California patients in pain amid prescription opioid shortage. What\u2019s causing the issue? KCRA Television 2024 https:\/\/www.kcra.com\/article\/california-patients-in-pain-prescription-opioid-shortage-investigation\/46757114 (Accessed 17 April 2025)."},{"key":"ref200\/cit200","volume-title":"DEA Keeping Supply of Rx Opioids unchanged in 2025","author":"Anson P.","year":"2024"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030727"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00613","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.4c00613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T07:12:42Z","timestamp":1752649962000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.4c00613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":199,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,11]]}},"alternative-id":["10.1021\/acsptsci.4c00613"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.4c00613","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}