{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:56:52Z","timestamp":1782586612459,"version":"3.54.5"},"reference-count":92,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,6,13]]},"DOI":"10.1021\/acsptsci.5c00011","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T11:45:36Z","timestamp":1748000736000},"page":"1627-1658","source":"Crossref","is-referenced-by-count":7,"title":["Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-\u03b3, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-6019","authenticated-orcid":true,"given":"Perihan A.","family":"Elzahhar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham A.","family":"Nematalla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy","place":["Damanhour, Egypt"]},{"name":"Damanhour University","place":["Damanhour, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak A.","family":"Abouayana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-239X","authenticated-orcid":true,"given":"El Sayed H.","family":"El Ashry","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Balbaa","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Petreni","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, FIorence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Nassra","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend A.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine N.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Elrewiny","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and the Research & Innovation Hub","place":["Alamein, Egypt"]},{"name":"Alamein International University","place":["Alamein, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-2819","authenticated-orcid":true,"given":"Mahmoud A.","family":"Agami","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and the Research & Innovation Hub","place":["Alamein, Egypt"]},{"name":"Alamein International University","place":["Alamein, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Makkar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and the Research & Innovation Hub","place":["Alamein, Egypt"]},{"name":"Alamein International University","place":["Alamein, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6053-9566","authenticated-orcid":true,"given":"Minh","family":"Sai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy","place":["Munich, Germany"]},{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-8128","authenticated-orcid":true,"given":"Daniel","family":"Merk","sequence":"additional","affiliation":[{"name":"Department of Pharmacy","place":["Munich, Germany"]},{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]},{"name":"Institute of Pharmaceutical Chemistry","place":["Frankfurt, Germany"]},{"name":"Goethe University Frankfurt","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala F.","family":"Labib","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy","place":["Alamein, Egypt"]},{"name":"Arab Academy of Science Technology and Maritime Transport","place":["Alamein, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Spagnuolo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Naldi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-3856","authenticated-orcid":true,"given":"Manuela","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, via Belmeloro 6, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad A.","family":"El-Hawash","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":true,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, FIorence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-0844","authenticated-orcid":true,"given":"Ahmed S. F.","family":"Belal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-3038","authenticated-orcid":true,"given":"Ahmed F.","family":"El-Yazbi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and the Research & Innovation Hub","place":["Alamein, Egypt"]},{"name":"Alamein International University","place":["Alamein, Egypt"]},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy","place":["Alexandria, Egypt"]},{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref1\/cit1","unstructured":"Global Report on\nDiabetes WHO Library Cataloguing-in-Publication Data Global Report\non Diabetes. 2016."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.554961"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.2991\/JEGH.K.191028.001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.006"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2019.07.009"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114491"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114041"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023227"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.18"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88884"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.07.003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-6-201003160-00004"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1125116"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041001"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.12.1661"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.341"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2337\/diab.32.9.804"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1427"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.009"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9389784"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801823R"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000040"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01192"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00420"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877938"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150716113501"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26103010"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.034"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1887169"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jm101360s"},{"key":"ref31\/cit31","first-page":"130","volume":"66","author":"Kinfe H. H.","year":"2013","journal-title":"S. Afr. J. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.03.041"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091230"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.003"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae303"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5427"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510080106"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.03.060"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2005.11.023"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.05.009"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3159"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13376"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1124\/molpharm.123.000704"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000116221.27079.ea"},{"issue":"5","key":"ref46\/cit46","first-page":"S61","volume":"15","author":"Schwartz G. J.","year":"2002","journal-title":"J. Nephrol."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1111\/J.1749-6632.1997.TB51831.X"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000434"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nm1534"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","unstructured":"El-Nikhely, N.; El-Yazbi, A. F. In  A Proposed Computational Workflow for Bioinformatics-Based Drug Repurposing: A Case Study of Canagliflozin, International Conference on Machine Intelligence and Smart Innovation, ICMISI 2024 - Proceedings; IEEE, 2024; pp 224\u2013227.","DOI":"10.1109\/ICMISI61517.2024.10580158"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz382"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.27173"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.01.001"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-024-03989-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-016-9915-2"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172695"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1713"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-022-00633-y"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28011"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21239005"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00145.2020"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133115"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1000-y"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.03.024"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.674"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M066530"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2121393"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0232OC"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2022.106621"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-012-9229-1"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.2337\/DC11-S241"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0428-9"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.00495.2006"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/jm300687e"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/bi00280a011"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112439"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.012"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEMBIOL.2021.04.019"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-946680"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03417"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.4103\/0973-8258.155062"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2013.1281"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003141"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.1.106"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032010000200009"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-1352(199909\/10)12:53.0.co;2-3"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01408"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115333"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116138"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1186\/S13065-023-00944-Z"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117415"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00011","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T08:12:04Z","timestamp":1749802324000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,13]]}},"alternative-id":["10.1021\/acsptsci.5c00011"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00011","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}