{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T10:53:58Z","timestamp":1791629638266,"version":"4.3.4"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL167877"],"award-info":[{"award-number":["R01HL167877"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,6,13]]},"DOI":"10.1021\/acsptsci.5c00030","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T02:33:36Z","timestamp":1747276416000},"page":"1669-1677","source":"Crossref","is-referenced-by-count":2,"title":["Multivalent Tranexamic Acid (TXA) and Benzamidine Derivatives for Serine Protease Inhibition"],"prefix":"10.1021","volume":"8","author":[{"given":"Tanmaye","family":"Nallan Chakravarthula","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]},{"name":"Weldon School of Biomedical Engineering","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Santillan-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]},{"name":"Weldon School of Biomedical Engineering","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres Prieto","family":"Trujillo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushri","family":"Umesh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]},{"name":"Weldon School of Biomedical Engineering","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-5137","authenticated-orcid":true,"given":"Nathan J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Indiana UniversitySchool of Medicine","place":["Indianapolis, United States"]},{"name":"Indiana University","place":["Indianapolis, United States"]},{"name":"Weldon School of Biomedical Engineering","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.186"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000533"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00128"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3348-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2016.1229718"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002139RR"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-017-1194-y"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-743385"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.08.042"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200611046"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0936"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.264903"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00772"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/bi2016519"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015127"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02496.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00742.x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.02.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67006-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.12.009"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ml400526d"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pr9020329"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14338"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1750-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2442"},{"key":"ref26\/cit26","unstructured":"Tsuda, Y.; Okada, Y.; Wanaka, K.; Tada, M.; Okamoto, S.; Hijikata-Okunomiya, A.; Konishi, Y.Design of Bivalent Plasmin Inhibitors.\n                      Peptide Science\u2500Present and Future: Proceedings of the 1st International Peptide Symposium\n                      ; Springer Netherlands 1999."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1968.tb00473.x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202200364"},{"key":"ref29\/ref29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00210a006"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jm981068g"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112146"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.117"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/med.21315"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.10.006"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.08.033"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00053-9"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00053-9"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.10.080"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02088A"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00030","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:09:22Z","timestamp":1778839762000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,13]]}},"alternative-id":["10.1021\/acsptsci.5c00030"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00030","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}