{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:03:17Z","timestamp":1787000597840,"version":"build-2736575974"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["4054783"],"award-info":[{"award-number":["4054783"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,6,13]]},"DOI":"10.1021\/acsptsci.5c00097","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T16:36:52Z","timestamp":1748623012000},"page":"1711-1725","source":"Crossref","is-referenced-by-count":2,"title":["Mechanism-Based Pharmacokinetic\/Pharmacodynamic Modeling for Iron-Regulated Hematopoietic Stem and Progenitor Cells\u2019 Commitment toward Erythroid and Megakaryocytic Lineages"],"prefix":"10.1021","volume":"8","author":[{"given":"Kangna","family":"Cao","sequence":"first","affiliation":[{"name":"Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmacy","place":["Hong Kong SAR"]},{"name":"The Chinese University of Hong Kong","place":["Hong Kong SAR"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmacy","place":["Hong Kong SAR"]},{"name":"The Chinese University of Hong Kong","place":["Hong Kong SAR"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond S. M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine and Therapeutics, Faculty of Medicine","place":["Hong Kong SAR"]},{"name":"The Chinese University of Hong Kong","place":["Hong Kong SAR"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-4313","authenticated-orcid":true,"given":"Xiaoyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmacy","place":["Hong Kong SAR"]},{"name":"The Chinese University of Hong Kong","place":["Hong Kong SAR"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3026(23)00160-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23682"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001130"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.270496"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.245092"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.09.021"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281149"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0939-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01662-3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002039"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/570241"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0885-7"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-191"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.03.006"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00122"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1177\/0091270011421911"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0894-2"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2165\/11317190-000000000-00000"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1296301"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020344"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.15.4.346"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-370607-2.X0001-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.12.010"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f4db"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12811"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.12.009"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512076112"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.116008"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12884"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2711313"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.5.1600.405k04_1600_1611"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.07.006"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.37.23366"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.4.1947"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203461"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13379"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.07.006"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1939"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.11.022"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23198"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-018-0005-8"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00648-1"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V15.1.45.45"},{"issue":"2","key":"ref45\/cit45","first-page":"164","volume":"19","author":"Abbaspour N.","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.01.011"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26189"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.11.022"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.12.020"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018943613122"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1994-31109"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/138.suppl2.24"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2020.11.007"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12507"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031742"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04100321"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa117"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00097","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:12:04Z","timestamp":1749787924000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,13]]}},"alternative-id":["10.1021\/acsptsci.5c00097"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00097","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]}}}