{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:12:57Z","timestamp":1790154777723,"version":"4.0.1"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2023\/002978"],"award-info":[{"award-number":["CRG\/2023\/002978"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/LS-I\/2020\/621"],"award-info":[{"award-number":["SR\/FST\/LS-I\/2020\/621"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,10,10]]},"DOI":"10.1021\/acsptsci.5c00198","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:27:06Z","timestamp":1753442826000},"page":"3490-3508","source":"Crossref","is-referenced-by-count":4,"title":["Lacosamide Interaction with Expanded CGG Repeats RNA and Its Role in Modulating Poly-Glycine Protein-Mediated Toxicity in Fragile-X Tremor\/Ataxia Syndrome"],"prefix":"10.1021","volume":"8","author":[{"given":"Krishna","family":"Singh","sequence":"first","affiliation":[{"name":"Mehta Family School of Biosciences and Biomedical Engineering","place":["Indore, India"]},{"name":"Indian Institute of Technology Indore","place":["Indore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Shukla","sequence":"additional","affiliation":[{"name":"Mehta Family School of Biosciences and Biomedical Engineering","place":["Indore, India"]},{"name":"Indian Institute of Technology Indore","place":["Indore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi Pramod","family":"Kumari","sequence":"additional","affiliation":[{"name":"Mehta Family School of Biosciences and Biomedical Engineering","place":["Indore, India"]},{"name":"Indian Institute of Technology Indore","place":["Indore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-4308","authenticated-orcid":true,"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Mehta Family School of Biosciences and Biomedical Engineering","place":["Indore, India"]},{"name":"Indian Institute of Technology Indore","place":["Indore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.011"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901484116"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/ja210088v"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63233-3.00009-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113042"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.21"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.1.127"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.82"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1073258"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106212"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-022-01116-y"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12693"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.866021"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00282"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-411-1_1"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.02.004"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.021"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.016"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.03.026"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab143"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2003.10.005"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-023-10524-3"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212441"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00533-6"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/srep18736"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00295"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcab114"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2017.13.2.138"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.05.021"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02697-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-024-01215-7"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp026"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201100337"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.013"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00699"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.05.001"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA05835K"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00147"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.020"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13419"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1534\/g3.116.027060"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48137-w"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-35"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105425"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.232"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1273-24"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3791\/51223"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38400-x"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-78947-6"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/srep39239"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5459.1837"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-015-0535-8"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)70787-2"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050238"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot066506"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-09141-0"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00198","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:13:00Z","timestamp":1760083980000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,10]]}},"alternative-id":["10.1021\/acsptsci.5c00198"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00198","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}