{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:09:33Z","timestamp":1778231373725,"version":"3.51.4"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["DD\/2020"],"award-info":[{"award-number":["DD\/2020"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["LSRB\/01\/15001\/M\/LSRB-378\/SH"],"award-info":[{"award-number":["LSRB\/01\/15001\/M\/LSRB-378\/SH"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008789","name":"Department of Science and Technology, Government of West Bengal","doi-asserted-by":"publisher","award":["1804 (Sanc.)\/ST\/P\/S&T\/9G-9\/2019"],"award-info":[{"award-number":["1804 (Sanc.)\/ST\/P\/S&T\/9G-9\/2019"]}],"id":[{"id":"10.13039\/501100008789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,5,8]]},"DOI":"10.1021\/acsptsci.5c00301","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:47:51Z","timestamp":1776196071000},"page":"1082-1098","source":"Crossref","is-referenced-by-count":0,"title":["Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-0720","authenticated-orcid":true,"given":"Abhishek","family":"Gupta","sequence":"first","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences","place":["Kolkata, India"]},{"name":"Indian Association for the Cultivation of Sciences","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuhin","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhamoy","family":"Pratihar","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences","place":["Kolkata, India"]},{"name":"Indian Association for the Cultivation of Sciences","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabnur","family":"Parvage","sequence":"additional","affiliation":[{"name":"Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swrajit Nath","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences","place":["Kolkata, India"]},{"name":"Indian Association for the Cultivation of Sciences","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnab","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Bioequivalence Study Centre","place":["Kolkata, India"]},{"name":"University of Jadavpur","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"De","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Bioequivalence Study Centre","place":["Kolkata, India"]},{"name":"University of Jadavpur","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanmoy","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Bioequivalence Study Centre","place":["Kolkata, India"]},{"name":"University of Jadavpur","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-0522","authenticated-orcid":true,"given":"Sanjit","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-1194","authenticated-orcid":true,"given":"Surajit","family":"Sinha","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences","place":["Kolkata, India"]},{"name":"Indian Association for the Cultivation of Sciences","place":["Kolkata, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S419239"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb02029.x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2015.01.005"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/10550880802122646"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3390\/ph14111091"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30430-1"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126495"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1556\/2054.2021.00152"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00529"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2017.1357184"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1556\/2054.2018.004"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1556\/2054.01.2016.001"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2021.108717"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1159\/000028246"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1992.tb00127.x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)00938-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1177\/02698811241237873"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00152"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","unstructured":"Hwu, C.; Havel, V.; Westergaard, X.; Mendieta, A. M.; Serrano, I. C.; Hwu, J.; Sames, D. Deciphering Ibogaine\u2019s Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses, 2025. 10.1101\/2025.03.04.641351.","DOI":"10.1101\/2025.03.04.641351"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05964-y"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-020-00342-0"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.209643"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.05.012"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-016-9366-y"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1177\/2045125315626073"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.927477"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-3008-z"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jm020562o"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.10.010"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51856-y"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030829"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00678"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2011.09.040"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.09.001"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400162"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00189"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20022208"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00193"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.06.027"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01714-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050455"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1159\/000028246"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)00938-9"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001968"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001386"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21896"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.02.019"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/32904"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919866529"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3565-17.2018"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22029"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311050002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174029"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2016.29.3.164"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00053-2"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12061"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70051819.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1139\/O08-001"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113203"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-021-09643-4"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154628"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154628"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.016"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153018"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.990926"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00301","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:10:39Z","timestamp":1778227839000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,8]]}},"alternative-id":["10.1021\/acsptsci.5c00301"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00301","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]}}}