{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:16:33Z","timestamp":1782015393728,"version":"3.54.5"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,9,12]]},"DOI":"10.1021\/acsptsci.5c00452","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:11:55Z","timestamp":1755846715000},"page":"3314-3333","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive Analysis of Clinically Discontinued Compounds Using an In Vitro Secondary Pharmacology Panel to Predict Potential Safety Risks during Drug Development"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3680-5225","authenticated-orcid":true,"given":"Verena","family":"Albert","sequence":"first","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Karnwal","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren N.","family":"Guili","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ledezma","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aura","family":"Celniker","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"De La Cruz","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Caliendo","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Galdieri","sequence":"additional","affiliation":[{"name":"Eurofins Discovery Services North America, LLC, 6 Research Park Drive, St. Charles, Missouri 63304, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair J.","family":"King","sequence":"additional","affiliation":[{"name":"Eurofins Discovery Services North America, LLC, 6 Research Park Drive, St. Charles, Missouri 63304, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Servant","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6899-4302","authenticated-orcid":true,"given":"Mirza","family":"Jahic","sequence":"additional","affiliation":[{"name":"Eurofins DiscoverX, LLC, 11180 Roselle Street, Suite D, San Diego, California 92121, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.002"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-019-00074-z"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.184"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4090"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3845"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-10-RV-062"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/tx060213n"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312464311"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.04.021"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00942-3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.03.008"},{"issue":"1","key":"ref12\/cit12","first-page":"37","volume":"157","author":"Rangno R.","year":"1997","journal-title":"CMAJ."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01880.x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)26444-0"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.23.2836"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jm400856t"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00435-w"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2017.02.020"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40064-9"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01127.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66398"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212852"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-323022"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412643"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.05.019"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4213"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.01.005"},{"key":"ref28\/cit28","unstructured":"News, G. Cardiac toxicity leads SuperGen to discontinue development of Phase I PIM inhibitor. 2011. https:\/\/www.genengnews.com\/news\/cardiac-toxicity-leads-supergen-to-discontinue-development-of-phase-i-pim-inhibitor\/ (accessed June 23, 2025)."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0109-y"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01721-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99200-8"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)24706-1"},{"issue":"3","key":"ref33\/cit33","first-page":"569","volume":"56","author":"Kohn E. C.","year":"1996","journal-title":"Cancer Res."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.781"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.19.9593"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830500409"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00694.2011"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1155"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1177\/1087057115594589"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-020-00311-6"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0653"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116540"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108082"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0058"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.11.016"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47010007"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfad012"},{"key":"ref48\/cit48","unstructured":"Jesse D. Rogers, G. P., E., Baker, A., Bettmann, A., Clippinger, K., Paul Friedman High-Throughput Safety Pharmacology to Better Understand Data-Poor Chemicals, 2024"},{"key":"ref49\/cit49","unstructured":"Food and Drug Administration FDA Announces Plan to Phase Out Animal\nTesting Requirement for Monoclonal Antibodies and Other Drugs. 2025. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-announces-plan-phase-out-animal-testing-requirement-monoclonal-antibodies-and-other-drugs  (accessed June 23, 2025)."},{"key":"ref50\/cit50","unstructured":"European Union Regulation (EC) No 1223\/2009 if the European Parliament\nand of the Council of 30 November 2009 on Cosmetic Products. 2009. https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX:02009R1223-20160812&from=EN (accessed June 23, 2025)."},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2022.107205"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.06.003"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00452","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:17:02Z","timestamp":1757665022000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,12]]}},"alternative-id":["10.1021\/acsptsci.5c00452"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00452","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}