{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:19:23Z","timestamp":1790245163731,"version":"4.1.0"},"reference-count":103,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":109,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES027704"],"award-info":[{"award-number":["P42 ES027704"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,11,14]]},"DOI":"10.1021\/acsptsci.5c00554","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:16:51Z","timestamp":1759522611000},"page":"4138-4158","source":"Crossref","is-referenced-by-count":6,"title":["Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-3962","authenticated-orcid":true,"given":"Chander K.","family":"Negi","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Sakolish","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Hsuan D.","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]},{"name":"Division of Toxicology","place":["Wageningen, The Netherlands"]},{"name":"Wageningen University and Research","place":["Wageningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Global Investigative Toxicology, Preclinical Safety","place":["Cambridge, United States"]},{"name":"Sanofi","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-8347","authenticated-orcid":true,"given":"Stephen S.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology","place":["Research Triangle Park, United States"]},{"name":"National Institute of Environmental Health Sciences","place":["Research Triangle Park, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Stanko","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology","place":["Research Triangle Park, United States"]},{"name":"National Institute of Environmental Health Sciences","place":["Research Triangle Park, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Chemical and Preclinical Safety","place":["Darmstadt, Germany"]},{"name":"Merck KGaA","place":["Darmstadt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kukla","sequence":"additional","affiliation":[{"name":"Development Sciences","place":["North Chicago, United States"]},{"name":"AbbVie Inc.","place":["North Chicago, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Development Sciences","place":["North Chicago, United States"]},{"name":"AbbVie Inc.","place":["North Chicago, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Villenave","sequence":"additional","affiliation":[{"name":"Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd","place":["Basel, Switzerland"]},{"name":"Roche Pharma Research and Early Development","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-7384","authenticated-orcid":true,"given":"Ivan","family":"Rusyn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology","place":["College Station, United States"]},{"name":"Texas A&M University","place":["College Station, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0183-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.014"},{"key":"ref3\/cit3","volume-title":"Roadmap to Reducing Animal Testing in Preclinical Safety Studies","author":"US FDA","year":"2025"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313369"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.07.001"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0105-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1399"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.02.015"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1750"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510263331702"},{"key":"ref11\/cit11","volume-title":"Review of the Fialuridine (FIAU) Clinical Trials","author":"Institute of Medicine","year":"1995"},{"key":"ref12\/cit12","first-page":"192","volume":"10","author":"Kleiner D. E.","year":"1997","journal-title":"Mod. Pathol."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199717010-00001"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.114667"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.119073"},{"key":"ref16\/cit16","volume-title":"Drug Approval Package: Tracleer (Bosentan) Tables; Company: Actelion, Ltd; Application No: 21\u2013290","author":"US FDA","year":"2001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.04.014"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/B978-0-12-387817-5.00025-X","volume-title":"Drug-Induced Liver Disease","author":"Larrey D.","year":"2013"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.460"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.08.037"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1829148"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.08.007"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25641"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/C2TX20051A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilw025"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1078-5"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.01.019"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00209-1"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1458"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00386-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00768G"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2001241"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/srep44517"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1177\/15353702211052280"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0079-3"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217715441"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152667"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03234-0"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax5516"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10101195"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbiosy.2022.100054"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2410112"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2022.105464"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152651"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00030-2"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac061"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12969"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.09.012"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC01161H"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40296-1"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(91)90109-P"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1963.205.5.848"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200334"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/srep25187"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001629RR"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx289"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2002-1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/srep35434"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaf012"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.10.020"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.5414\/CP201806"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.9.2134"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.03.019"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12003"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-022-00148-1"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02427-4"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.06.045"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0223"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006443104670"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2016.153"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-6-39"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26160"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.013615"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70938-6"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443150-00003"},{"key":"ref76\/cit76","first-page":"185","volume":"7","author":"Messiha F. S.","year":"1985","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz195"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1031"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1074"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaf036"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31999"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1289\/EHP10800"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3645"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v6.i4.522"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3727\/105221618X15156018385515"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205244200"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.105029"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1375962"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116049"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy058"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpet.2025.103408"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2014.944612"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.13.8940293"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i5.699"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.2.2914628"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2022.06.004"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00663E"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00554","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:29:24Z","timestamp":1768926564000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":103,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,14]]}},"alternative-id":["10.1021\/acsptsci.5c00554"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00554","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]}}}