{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:55:30Z","timestamp":1785894930234,"version":"3.56.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F. 82-44\/2020 (SA-III)"],"award-info":[{"award-number":["F. 82-44\/2020 (SA-III)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,11,14]]},"DOI":"10.1021\/acsptsci.5c00592","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T15:43:46Z","timestamp":1761839026000},"page":"4172-4188","source":"Crossref","is-referenced-by-count":1,"title":["Mild and Severe Hypertension Differentially Induce Internal Circadian Misalignment, Sleep\u2013Wake Fragmentation, and Neurocardiac Desynchronization in Rats"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5032-2622","authenticated-orcid":true,"given":"Neeraj","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering & Technology","place":["Varanasi, India"]},{"name":"Indian Institute of Technology (Banaras Hindu University)","place":["Varanasi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-2463","authenticated-orcid":true,"given":"Sairam","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering & Technology","place":["Varanasi, India"]},{"name":"Indian Institute of Technology (Banaras Hindu University)","place":["Varanasi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref1\/cit1","unstructured":"WHO.\n                      Hypertension.\n                      2023. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hypertension."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5432"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.37"},{"key":"ref4\/cit4","unstructured":"SBU. Moderately elevated\nblood pressure. Stockholm: Swedish Council\non Health Technology Assessment in Health Care (SBU); 2007.\n                      SBU report no 170 (in Swedish).\n                      www.sbu.se\/en\/publications\/sbu-assesses\/moderately-elevated-blood-pressure\/."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5719"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd006742.pub2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1995.tb04116.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010711"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2019028841"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014563535"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.11.024"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.281.2.F264"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00324.2010"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.6.R1719"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2024.200305"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003028"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00136.2009"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00097.2003"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209957"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03546-w"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12942"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-016-0450-7"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109433"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.09.002"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1177\/07487304251349408"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1242800"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.12.010"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2019.02.018"},{"key":"ref30\/cit30","unstructured":"Fryar, C. D.; Kit, B.; Carroll, M. D.; Afful, J.\n                      United States, August 2021\u2500August 2023 NCHS Data Brief. 2024 Oct;(511):CS354233. PMID: 40085792\n                      . 2024. https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db511.htm."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15650"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.3.H794"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/biology12071030"},{"issue":"2","key":"ref34\/cit34","first-page":"175","volume":"63","author":"Mondal K.","year":"2019","journal-title":"Indian J. Physiol Pharmacol."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091713"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410180039004"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.06.033"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3329\/jsf.v14i1.29499"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.36"},{"issue":"2","key":"ref40\/cit40","first-page":"259","volume":"92","author":"Nicholls S. K.","year":"2019","journal-title":"Yale J. Biol. Med."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42758-6"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.054"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.06.013"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2017.1338716"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16109"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13707"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1083"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000056521.67546.AA"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-1-1"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61050794"},{"key":"ref51\/cit51","volume-title":"hard cover ed.","author":"Paxinos G.","year":"2006"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.10.002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14950"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440400111013"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.2014-0122"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-55860-377-6.50032-3"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s10994-006-6889-7"},{"issue":"265","key":"ref58\/cit58","first-page":"1","volume":"25","author":"Ankan A.","year":"2024","journal-title":"J. Mach. Learn. Res."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.25080\/TCWV9851"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00592","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:11:21Z","timestamp":1763111481000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,14]]}},"alternative-id":["10.1021\/acsptsci.5c00592"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00592","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}