{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:05:38Z","timestamp":1789041938078,"version":"build-2803163510"},"reference-count":249,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2024\/GNT2036793"],"award-info":[{"award-number":["2024\/GNT2036793"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["SCHNEI24I0"],"award-info":[{"award-number":["SCHNEI24I0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,2,13]]},"DOI":"10.1021\/acsptsci.5c00640","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:22:41Z","timestamp":1768490561000},"page":"282-306","source":"Crossref","is-referenced-by-count":1,"title":["When Neutrophils Go Rogue: Dysregulated Inflammation in Airway Diseases and Implications for Therapy"],"prefix":"10.1021","volume":"9","author":[{"given":"Yimin","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences","place":["Parkville, Australia"]},{"name":"The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmi","family":"Sardar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences","place":["Parkville, Australia"]},{"name":"The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biomedicine Discovery Institute","place":["Clayton, Australia"]},{"name":"Monash University","place":["Clayton, Australia"]},{"name":"Centre for Innate Immunity and Infectious Diseases","place":["Clayton, Australia"]},{"name":"Hudson Institute of Medical Research","place":["Clayton, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A. B.","family":"Wark","sequence":"additional","affiliation":[{"name":"Respiratory Medicine School of Translational Medicine","place":["Melbourne, Australia"]},{"name":"Monash University","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6810-6149","authenticated-orcid":true,"given":"Laura E.","family":"Edgington-Mitchell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences","place":["Parkville, Australia"]},{"name":"The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-4824","authenticated-orcid":true,"given":"Elena K.","family":"Schneider-Futschik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences","place":["Parkville, Australia"]},{"name":"The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1841"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.9907064"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9606120"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2105083"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00095-21"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb11000.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.08.006"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d21.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12730"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0001-2024"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.20517\/rdodj.2022.21"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0054-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15803"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-2-3-98"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13173"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004850200"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200470109"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702615200"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1997.tb00940.x"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12440"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.17.8215"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00212114"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaq0693"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104760"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1572-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1136\/thx.39.9.663"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00140.2004"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114699"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(82)80053-3"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72667-3"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.10.009"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3366"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34694"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0883-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2020.3328"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90626-V"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.014902"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00020809"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30504-X"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.3.775"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002733"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01910-2017"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.002"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.707109"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.25.15514"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0241-2021"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009432"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50197-0"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07857-w"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00347-2024"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108753"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1601OC"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13870"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3488"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520783"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210134"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.11.004"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.11.007"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nm1690"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-03970-x"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0300-8"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.600033"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.1.L33"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.05.017"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901716"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01200-2015"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.7912987"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14450"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-555268"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-159921"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00252"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171249"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/bi060490t"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009934"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00697.x"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad139"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30434-4"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2021.05.006"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13479"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00511-7"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062209"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01436-7"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112525"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-1480"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1410158"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200603-078AW"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1590OC"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/path.4359"},{"issue":"56","key":"ref92\/cit92","first-page":"387","volume":"40","author":"Thomas C.","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18411.1"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.164159"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010132"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.2.L412"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201008-1285OC"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.04.011"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200279"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0403OC"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2023.PA4043"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00950-2023"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126351"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02343-3"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01678-2019"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400132"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0433OC"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41196"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500038"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct109"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0015-2023"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.11.008"},{"key":"ref113\/cit113","first-page":"6","volume":"147","author":"Cole P. J.","year":"1986","journal-title":"Eur. J. Respir Dis. Suppl."},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03157-2020"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S4385"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1889OC"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00176-0"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/642503"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2423OC"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081065"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1027OC"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119325"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1279837"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-216475"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02301-5"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212895"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2020.3327"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-60"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1007\/BF01489487"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01154"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2023.PA2342"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215986"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.1009"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108150"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70128-1"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.07.003"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9806170"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9809071"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab3142"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13236"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.157719"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2015.1041606"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1329"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.4.9105080"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1096\/fsb2fj000378com"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1103"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213521"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12859"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1869OC"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80911"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2678"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.01.012"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4701"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00750-8"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.120741"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13986"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080814"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-0991OC"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.10.012"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1012310"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0499OC"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00120-2022"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.09.032"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2021.102095"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00302"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152371"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30227-2"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00148-2015"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01401-4"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0992OC"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1240"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.6.1523"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.12.009"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.08.007"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706495"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.092056"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105030"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00185-5"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0065OC"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.075937"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62410-7"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.10.006"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2024.PA1777"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1142-7"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.740803"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00170.x"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202306-0944OC"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.07.168"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154964"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2018.0015"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60860-1"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30430-1"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.2023.0407"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2024.PA1777"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114305"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00537-2024"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146807"},{"key":"ref199\/cit199","first-page":"A2839","author":"Miglietta D.","year":"2018","journal-title":"In B25. CHRONIC SUPPURATIVE LUNG DISEASE IN CHILDREN"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.12.009"},{"key":"ref201\/cit201","doi-asserted-by":"crossref","unstructured":"Wells, J. M.; Hatipoglu, U. S.; Goldklang, M. P.; D\u2019Armiento, J. M.; Pirozzi, C. S.; Drummond, M. B.; Barjaktarevic, I.; Chatila, W.; Devine, M. S.; Strange, C.; Sandhaus, R. A.; Parkin, J.; Stockley, R. A.; Westfall, E.; Lin, V. Y.; Parks, R.; Kuo, H. C.; Aban, I.; Dransfield, M. T.\n                      Alvelestat (MPH966) for the Treatment of Alpha-1 Antitrypsin Deficiency (ATALANTa): A Phase 2, Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of Alvelestat in Alpha-1 Antitrypsin Deficiency\n                      . American Thoracic Society International Conference Abstracts, American Thoracic Society, 2024; pp A1211\u2013A1211.","DOI":"10.1164\/ajrccm-conference.2024.209.1_MeetingAbstracts.A1211"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2024.PA3005"},{"key":"ref203\/cit203","volume-title":"Alvelestat (MPH966)","author":"BioPharma M.","year":"2025"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2019.03.009"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00252-2018"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000133332.48386.85"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.03.001"},{"key":"ref208\/cit208","first-page":"A2839","volume-title":"B25. CHRONIC SUPPURATIVE LUNG DISEASE IN CHILDREN","author":"McElvaney O. J.","year":"2018"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2011.641803"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01774-4"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13398"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","unstructured":"Guan, W.; Zhong, N.; Qiu, R.; Cao, J.; Huang, Y.; Zhou, H.; Xu, X.; Ye, H.; Yang, Z.; Gao, L.; Shen, Y.; Xiao, Z.; Xie, S.; Lin, D.; Zhao, L.; Xiong, H.; Zhang, X.; Zhang, G.; Zhang, X.; Li, Y.; Xu, J.; Wen, F.; Song, Y.; Wang, L.; Lin, Y. Late Breaking Abstract - Phase 2 trial of HSK31858, a novel DPP1 inhibitor, in bronchiectasis.\n                      Eur. Respiratory J.\n                      64 (suppl 68), PA3001. DOI: 10.1183\/13993003.congress-2024.PA3001.","DOI":"10.1183\/13993003.congress-2024.PA3001"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(25)00019-0"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00151-2024"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-022-01331-5"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12474-5"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213462"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5A1015-489R"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76009"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7277"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.02.009"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14618-8"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0532-0"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13891"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00633-2022"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2023.PA2836"},{"key":"ref227\/cit227","unstructured":"Kingwell, K.\n                      Neutrophil-targeted drug secures first FDA approval for inflammatory lung disease\n                      . 2025. https:\/\/www.nature.com\/articles\/d41573-025-00135-6 (accessed 10\/10\/2025 12\/08\/2025)."},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01127"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021713"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02444-z"},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2411664"},{"key":"ref232\/cit232","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-025-01550-z"},{"key":"ref233\/cit233","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2025.149257"},{"key":"ref234\/cit234","doi-asserted-by":"publisher","DOI":"10.3390\/cells12121555"},{"key":"ref235\/cit235","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12922-y"},{"key":"ref236\/cit236","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43904-w"},{"issue":"2","key":"ref237\/cit237","volume":"17","author":"Afrin S.","year":"2025","journal-title":"Cureus"},{"key":"ref238\/cit238","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00403"},{"key":"ref239\/cit239","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-025-00227-1"},{"key":"ref240\/cit240","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0141-8"},{"key":"ref241\/cit241","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae300"},{"key":"ref242\/cit242","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.03.009"},{"key":"ref243\/cit243","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.03.006"},{"key":"ref244\/cit244","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1MR1221-345R"},{"key":"ref245\/cit245","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.03.005"},{"key":"ref246\/cit246","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.003"},{"key":"ref247\/cit247","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00163208"},{"key":"ref248\/cit248","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12219"},{"key":"ref249\/cit249","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0234-2023"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00640","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:11:45Z","timestamp":1770973905000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":249,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,13]]}},"alternative-id":["10.1021\/acsptsci.5c00640"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00640","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]}}}