{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:07:24Z","timestamp":1770977244242,"version":"3.50.1"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012728","name":"Frederick National Laboratory for Cancer Research","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100012728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","award":["ZIABC011065"],"award-info":[{"award-number":["ZIABC011065"]}],"id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","award":["ZIABC011627"],"award-info":[{"award-number":["ZIABC011627"]}],"id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Continuing Umbrella of Research Experiences program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,2,13]]},"DOI":"10.1021\/acsptsci.5c00644","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:22:35Z","timestamp":1769106155000},"page":"370-384","source":"Crossref","is-referenced-by-count":0,"title":["SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13\n                    <sup>Pru<\/sup>\n                    Degrader"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-3062","authenticated-orcid":true,"given":"Christine S.","family":"Brugger-Muli","sequence":"first","affiliation":[{"name":"Protein Processing Section, Center for Structural Biology Center for Cancer Research","place":["Frederick, United States"]},{"name":"National Cancer Institute, National Institutes of Health","place":["Frederick, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehal M.","family":"Gaikwad","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Biology and Genetics","place":["Bethesda, United States"]},{"name":"National Cancer Institute, National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"du Bois","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Biology and Genetics","place":["Bethesda, United States"]},{"name":"National Cancer Institute, National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-2812","authenticated-orcid":true,"given":"Venkata R.","family":"Sabbasani","sequence":"additional","affiliation":[{"name":"Chemistry and Synthesis Center","place":["Bethesda, United States"]},{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf E.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Chemistry and Synthesis Center","place":["Bethesda, United States"]},{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-0536","authenticated-orcid":true,"given":"William F.","family":"Heinz","sequence":"additional","affiliation":[{"name":"Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program","place":["Frederick, United States"]},{"name":"Frederick National Laboratory for Cancer Research","place":["Frederick, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler J.","family":"Peat","sequence":"additional","affiliation":[{"name":"Labcorp","place":["Greenfield, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly A.","family":"Mock","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Biology and Genetics","place":["Bethesda, United States"]},{"name":"National Cancer Institute, National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie J.","family":"Walters","sequence":"additional","affiliation":[{"name":"Protein Processing Section, Center for Structural Biology Center for Cancer Research","place":["Frederick, United States"]},{"name":"National Cancer Institute, National Institutes of Health","place":["Frederick, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.10.009"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.206"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/9781119774198.ch4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.06.006"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.10.009"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2021.02.009"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-025-01262-w"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01218-w"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00422"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00485"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00793"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06238-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.013"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.122.001154"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2024.102811"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.04.002"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.11.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b02069"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900017"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129485"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04064"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0467-z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27570-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46644-7"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108520"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.04.019"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nature06926"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nature06924"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60843-w"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140518"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.785287"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15540"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.18632\/genesandcancer.197"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.11.035"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601338"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601450"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1460"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.10.017"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ci5005288"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.82950"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01022.x"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.02.001"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-010-9203-3"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014276917363"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2025.114651"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.156"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/61\/1\/192"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2009.09.005"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2009.05.028"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s11249-014-0459-0"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00122-20"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.08.007"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.012"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01559-0"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.02.006"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-12-5"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S214008"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.05.003"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305000110"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.07.051"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/med.21981"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1817"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160719163839"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02085"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071983"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01272-5"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00644","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:12:09Z","timestamp":1770973929000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,13]]}},"alternative-id":["10.1021\/acsptsci.5c00644"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00644","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]}}}