{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:09:36Z","timestamp":1782436176651,"version":"3.54.5"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["311\/CDADAH\/4401009"],"award-info":[{"award-number":["311\/CDADAH\/4401009"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2020\/STG04\/USM\/02\/6"],"award-info":[{"award-number":["FRGS\/1\/2020\/STG04\/USM\/02\/6"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,1,9]]},"DOI":"10.1021\/acsptsci.5c00647","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:27:30Z","timestamp":1765366050000},"page":"126-140","source":"Crossref","is-referenced-by-count":4,"title":["Optimization of a Green Extraction Technique for Kratom (Ketum) Leaf Extract via Accelerated Solvent Extraction: Phytochemical Profiles, Cytotoxicity, and Antinociceptive Activity"],"prefix":"10.1021","volume":"9","author":[{"given":"Nurul Najwa","family":"Rusmadi","sequence":"first","affiliation":[{"name":"Centre for Drug Research","place":["Pulau Pinang, Malaysia"]},{"name":"Universiti Sains Malaysia","place":["Pulau Pinang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4470-2656","authenticated-orcid":true,"given":"Thiruventhan","family":"Karunakaran","sequence":"additional","affiliation":[{"name":"Centre for Drug Research","place":["Pulau Pinang, Malaysia"]},{"name":"Universiti Sains Malaysia","place":["Pulau Pinang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiqah","family":"Ramli","sequence":"additional","affiliation":[{"name":"Department of Bioprocess & Polymer Engineering, School of Chemical & Energy Engineering, Faculty of Engineering","place":["Johor Bahru, Malaysia"]},{"name":"Universiti Teknologi Malaysia","place":["Johor Bahru, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-0022","authenticated-orcid":true,"given":"Intan Safinar","family":"Ismail","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Medicine & Products Research Laboratory, Institute of Bioscience","place":["Serdang, Malaysia"]},{"name":"Universiti Putra Malaysia","place":["Serdang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameshkumar","family":"Santhanam","sequence":"additional","affiliation":[{"name":"BioSES Research Interest Group, Faculty of Science and Marine Environment","place":["Kuala Nerus, Malaysia"]},{"name":"Universiti Malaysia Terengganu","place":["Kuala Nerus, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Yuvenesan Jagabalan","sequence":"additional","affiliation":[{"name":"Centre for Drug Research","place":["Pulau Pinang, Malaysia"]},{"name":"Universiti Sains Malaysia","place":["Pulau Pinang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Hafizi","family":"Abu Bakar","sequence":"additional","affiliation":[{"name":"Bioprocess Technology Division, School of Industrial Technology","place":["Pulau Pinang, Malaysia"]},{"name":"Universiti Sains Malaysia","place":["Pulau Pinang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azira","family":"Muhamad","sequence":"additional","affiliation":[{"name":"Malaysia Genome and Vaccine Institute","place":["Kajang, Malaysia"]},{"name":"National Institutes of Biotechnology Malaysia","place":["Kajang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surash","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Centre for Drug Research","place":["Pulau Pinang, Malaysia"]},{"name":"Universiti Sains Malaysia","place":["Pulau Pinang, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/968786"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.03.009"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2015.1012610"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-015-1279-y"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2022.101442"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.020"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1201\/b17666"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123704"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.07.013"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.805986"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959578"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.012"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0412.1000196"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c00257"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2013.01.014"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/app8101905"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-019-03958-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2020.100327"},{"key":"ref19\/cit19","volume-title":"Embedded Mechatronic Systems 2: Analysis of Failures, Modeling, Simulation and Optimization","author":"Abdelkhalak E. H.","year":"2020","edition":"2"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/869120"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2362428"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)09094-9"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.09.036"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c22-00441"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01055"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c00257"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234267"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01465"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.14-110"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2014.02.045"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/md16050154"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkz103"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00335"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13644"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201300804"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.06.062"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.10.002"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-148"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2017.1382376"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20034915"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.6339"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-016-0588-y"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1177\/2324709619826167"},{"key":"ref44\/cit44","volume-title":"Fundamentals of Pharmacognosy and Phytotherapy","author":"Heinrich M.","year":"2017","edition":"2"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60076-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.2017931"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1005011"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098096"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.113938"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/C5TX00113G"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29061404"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2014.10.003"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3390\/md19030139"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283147"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3906"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00726"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01163"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00647","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:15:39Z","timestamp":1768569339000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"alternative-id":["10.1021\/acsptsci.5c00647"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00647","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]}}}