{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:07:19Z","timestamp":1775812039545,"version":"3.50.1"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2873 - 494832089"],"award-info":[{"award-number":["GRK 2873 - 494832089"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,4,10]]},"DOI":"10.1021\/acsptsci.5c00722","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T14:06:38Z","timestamp":1774706798000},"page":"954-965","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Heparin and Heparin Mimetics in Targeting Immunomodulatory Proteins from Platelets to Activate T Cell-Dependent Immune Response in Oncology"],"prefix":"10.1021","volume":"9","author":[{"given":"Katrin","family":"Nekipelov","sequence":"first","affiliation":[{"name":"Pharmaceutical Institute, Pharmaceutical and Cell Biological Chemistry","place":["Bonn, Germany"]},{"name":"University of Bonn","place":["Bonn, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Otto","sequence":"additional","affiliation":[{"name":"Pharmaceutical Institute, Pharmaceutical and Cell Biological Chemistry","place":["Bonn, Germany"]},{"name":"University of Bonn","place":["Bonn, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Henseler","sequence":"additional","affiliation":[{"name":"Pharmaceutical Institute, Pharmaceutical and Cell Biological Chemistry","place":["Bonn, Germany"]},{"name":"University of Bonn","place":["Bonn, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Vidal-y-Sy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology","place":["Hamburg, Germany"]},{"name":"University Medical Center Hamburg-Eppendorf","place":["Hamburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Al Nahain","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Bioscience","place":["Brisbane, Australia"]},{"name":"University of Queensland","place":["Brisbane, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gorzelanny","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology","place":["Hamburg, Germany"]},{"name":"University Medical Center Hamburg-Eppendorf","place":["Hamburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-2550","authenticated-orcid":true,"given":"Vito","family":"Ferro","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Bioscience","place":["Brisbane, Australia"]},{"name":"University of Queensland","place":["Brisbane, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-7201","authenticated-orcid":true,"given":"Gerd","family":"Bendas","sequence":"additional","affiliation":[{"name":"Pharmaceutical Institute, Pharmaceutical and Cell Biological Chemistry","place":["Bonn, Germany"]},{"name":"University of Bonn","place":["Bonn, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"ref1\/cit1","unstructured":"Global cancer burden growing,\namidst mounting need for services\n                      . https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing-amidst-mounting-need-for-services (accessed 2025\u201303\u201320)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2474"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.343251.120"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0669-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12072"},{"key":"ref7\/cit7","unstructured":"Egan, K.; Cooke, N.; Kenny, D.\n                      Living in shear: platelets protect cancer cells from shear induced damage\n                      . https:\/\/link.springer.com\/article\/10.1007\/s10585-014-9660-7 (accessed 2025\u201304\u201303)."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.115159"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2357"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7911"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08626-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.07.008"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.02.026"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201353"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094492"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10454"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01764-w"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-151753"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2123"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nri2808"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01370"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413691"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06632.x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/386616a0"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2019.10.009"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01306.x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.5.7703"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0125OC"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.01.037"},{"key":"ref30\/cit30","unstructured":"Guidelines\n& Protocols\nAdvisory Committee.\n                      Venous thromboembolism\n\u2013 diagnosis and management: Effective date February 29, 2024\n                      . BC Guidelines, 2024. https:\/\/www2.gov.bc.ca\/assets\/gov\/health\/practitioner-professional-resources\/bc-guidelines\/vte-guideline.pdf"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00160-7"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2020.1767489"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03186-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2334-8"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400633"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68547-3"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006608"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c20744"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/s130912392"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-1041"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1078891"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200580"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00177-8"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00722","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:11:25Z","timestamp":1775808685000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,10]]}},"alternative-id":["10.1021\/acsptsci.5c00722"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00722","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]}}}