{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:56:56Z","timestamp":1781254616214,"version":"3.54.1"},"reference-count":87,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/200.154\/2023"],"award-info":[{"award-number":["E-26\/200.154\/2023"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.678\/2021"],"award-info":[{"award-number":["E-26\/211.678\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.912071\/2023-00"],"award-info":[{"award-number":["88887.912071\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,6,12]]},"DOI":"10.1021\/acsptsci.5c00772","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:43:14Z","timestamp":1780083794000},"page":"1412-1425","source":"Crossref","is-referenced-by-count":0,"title":["Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4517-5305","authenticated-orcid":true,"given":"Gabriela Pereira","family":"Milhm","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universit\u00e1ria, Rio de Janeiro, Brazil 21941-902"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-2665","authenticated-orcid":true,"given":"Fernanda de Lima","family":"Moreira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacometrics, Faculty of Pharmacy","place":["Rio de Janeiro, Brazil"]},{"name":"Federal University of Rio de Janeiro (UFRJ)","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-0169","authenticated-orcid":true,"given":"B\u00e1rbara de Azevedo","family":"Abrahim-Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universit\u00e1ria, Rio de Janeiro, Brazil 21941-902"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization\n                      Diabetes\n                      ; World\nHealth Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes (accessed 2023-07\u201317)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01174-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108330"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.4498"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32129-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109785"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105141"},{"key":"ref11\/cit11","unstructured":"Sociedade Brasileira\nde Diabetes.\n                      Diretrizes Sociedade\nBrasileira De Diabetes\n2019-2020\n                      , 2019. https:\/\/www.saude.ba.gov.br\/wp-content\/uploads\/2020\/02\/Diretrizes-Sociedade-Brasileira-de-Diabetes-2019-2020.pdf (accessed 2025\u201306\u201325)."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2017.10.02"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-00713-1"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100165"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12719"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-018-0187-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3039"},{"key":"ref19\/cit19","unstructured":"European Medicines Agency\n                      Assessment Report: Jardiance. International\nNon-Proprietary Name: Empagliflozin\n                      2016. https:\/\/www.ema.europa.eu\/en\/documents\/variation-report\/jardiance-h-c-2677-ii-0014-epar-assessment-report_en.pdf."},{"key":"ref20\/cit20","unstructured":"U.S.\nFood and Drug Administration.\n                      Drug\nApproval Package\n                      ; Jardiance (Empagliflozin), 2014. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2014\/204629Orig1s000TOC.cfm. (accessed 2025\u201306\u201325)."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00388.2010"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051013-110046"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002772021"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1171-0"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0903-4"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13629"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.532"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12540"},{"key":"ref29\/cit29","unstructured":"World\nHealth Organization.\n                      Children are\nNot Little Adults: Training\nfor Health Care Providers\n                      ; World Health Organization. https:\/\/iris.who.int\/handle\/10665\/331237 (accessed 2025-06\u201325)."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac101"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107541"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.298"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.37"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100540"},{"key":"ref35\/cit35","unstructured":"European\nMedicines Agency.\n                      Guideline on the\nReporting of Physiologically\nBased Pharmacokinetic (PBPK) Modelling and Simulation\n                      , 2018. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-reporting-physiologically-based-pharmacokinetic-pbpk-modelling-and-simulation_en.pdf (accessed 2025\u201306\u201325)."},{"key":"ref36\/cit36","unstructured":"European Medicines Agency.\n                      ICH Guideline E11A on Pediatric Extrapolation\n                      , 2022. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/draft-ich-guideline-e11a-pediatric-extrapolation-step-2b_en.pdf (accessed 2025\u201306\u201325)."},{"key":"ref37\/cit37","unstructured":"U.S. Food and Drug Administration.\n                      The Use of Physiologically Based Pharmacokinetic\nAnalyses\u2500Biopharmaceutics Applications for Oral Drug Product\nDevelopment, Manufacturing Changes, and Controls Guidance for Industry\n                      , 2020. https:\/\/www.fda.gov\/media\/142500\/download."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12234"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12915"},{"key":"ref40\/cit40","unstructured":"PubChem.\n                      Empagliflozin\n                      ; PubChem. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Empagliflozin (accessed\n2023-07\u201319)."},{"key":"ref41\/cit41","unstructured":"Therapeutic Goods Administration.\n                      Australian Public Assessment Report for\nEmpagliflozin\n                      . https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-empagliflozin-150127.pdf."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.22456\/2527-2616.112077"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.20.452"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2413"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2022.105210"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20502"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22726"},{"key":"ref48\/cit48","unstructured":"Open\nSystems Pharmacology.\n                      PKSim and MoBi\nHandbook\n                      . https:\/\/docs.open-systems-pharmacology.org\/ (accessed 2025-06\u201325)."},{"key":"ref49\/cit49","unstructured":"DrugBank.\n                      Empagliflozin\n                      ; DrugBank. https:\/\/go.drugbank.com\/drugs\/DB09038 (accessed 2023-07\u201314)."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00503.2017"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0055-3"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.12.002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.16"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-013-0030-2"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12073"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12183"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12182"},{"key":"ref58\/cit58","unstructured":"European\nMedicines Agency.\n                      Committee for Medicinal\nProducts for Human\nUse (CHMP) Guideline on the Reporting of Physiologically Based Pharmacokinetic\n(PBPK) Modelling and Simulation\n                      , 2018. www.ema.europa.eu\/contact."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1013"},{"key":"ref60\/cit60","unstructured":"World\nHealth Organization.\n                      Child Growth\nStandards\n                      . https:\/\/www.who.int\/tools\/child-growth-standards."},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-060640"},{"key":"ref62\/cit62","first-page":"1","author":"Kuczmarski R. J.","year":"2000","journal-title":"Vital Health Stat. 11"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-022-01132-3"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-021-01072-4"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2034"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-024-01367-2"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.13102"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13059"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.22037\/jpn.v7i3.26495"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-012-9412-7"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20497"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2018-0006"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688477"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-021-01072-4"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1142003"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1520268"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039030-00004"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.70014"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020179"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12787"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111074"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12134"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.659"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-082"},{"key":"ref85\/cit85","unstructured":"U.S.\nFood and Drug Administration.\n                      FDA\nApproves New Class of Medicines to Treat\nPediatric Type 2 Diabetes\n                      . https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-class-medicines-treat-pediatric-type-2-diabetes."},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70096"},{"key":"ref87\/cit87","unstructured":"U.S. Food and Drug Administration.\n                      Office of Clinical Pharmacology Review (Jardiance)\n                      . https:\/\/www.fda.gov\/media\/172971\/download."}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00772","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:12:20Z","timestamp":1781251940000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":87,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,12]]}},"alternative-id":["10.1021\/acsptsci.5c00772"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00772","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}