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However, conventional treatments are often accompanied by large side effects and limited efficacy. In recent years, mitochondria, as the core organelles of cellular energy metabolism, oxidative stress regulation, and apoptosis execution, have played a key role in breast cancer development, progression, metastasis, and treatment resistance. Therefore, many researchers have turned their attention to mitochondria to open up new pathways for the treatment of breast cancer. This review systematically outlines the relationship between mitochondrial energy metabolism, antiapoptotic proteins, mitochondrial fusion\/fission, mitochondrial autophagy, and ferroptosis and breast cancer cell proliferation, metastasis, and drug resistance, summarizes and analyzes the inhibitory effects of drugs or therapeutics targeting mitochondria, and explores the strategies of targeting mitochondria for the treatment of breast cancer to provide new ideas and methods for the treatment of breast cancer.<\/jats:p>","DOI":"10.1021\/acsptsci.5c00823","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:44:01Z","timestamp":1782992641000},"page":"2008-2023","source":"Crossref","is-referenced-by-count":0,"title":["Strategies for\nTargeting Mitochondria in the Treatment\nof Breast Cancer"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6638-4053","authenticated-orcid":true,"given":"Kexin","family":"Wang","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichuan","family":"Deng","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Power China Chengdu Engineering Corporation Limited , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Shuai","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqi","family":"Li","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-5257","authenticated-orcid":true,"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-0282","authenticated-orcid":true,"given":"Jianyou","family":"Shi","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Bai","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China , , ,","place":["Chengdu, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"9","key":"2026081411070365900_cit1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.32288","article-title":"COVID-19\nand Rates of Cancer Diagnosis in the US","volume":"7","author":"Burus","year":"2024","journal-title":"JAMA\nNetwork Open"},{"key":"2026081411070365900_cit2","doi-asserted-by":"publisher","first-page":"102339","DOI":"10.1016\/j.ctrv.2022.102339","article-title":"Global challenges\nand policy solutions in breast cancer control","volume":"104","author":"Trapani","year":"2022","journal-title":"Cancer Treat Rev."},{"issue":"1","key":"2026081411070365900_cit3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/jnci\/djae221","article-title":"NCCN guideline-concordant cancer care in sub-Saharan\nAfrica: a population-based multicountry study of 5 cancers","volume":"117","author":"Mezger","year":"2025","journal-title":"J. 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