{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:01:18Z","timestamp":1790870478493,"version":"4.1.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A670624"],"award-info":[{"award-number":["N42A670624"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022271","name":"Faculty of Veterinary Medicine, Kasetsart University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005621","name":"Kasetsart University Research and Development Institute","doi-asserted-by":"publisher","award":["FF(KU)7.68"],"award-info":[{"award-number":["FF(KU)7.68"]}],"id":[{"id":"10.13039\/501100005621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,6,12]]},"DOI":"10.1021\/acsptsci.6c00016","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:19:48Z","timestamp":1778077188000},"page":"1451-1464","source":"Crossref","is-referenced-by-count":1,"title":["Repurposing FDA-Approved Drugs as Potential Inhibitors of Feline Infectious Peritonitis Virus 3CL\n                    <sup>pro<\/sup>\n                    : An Integrated In Silico and In Vitro Study with Synergistic Combination Analysis"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5953-976X","authenticated-orcid":true,"given":"Varanya","family":"Lueangaramkul","sequence":"first","affiliation":[{"name":"Graduate Program in Animal Health and Biomedical Sciences, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]},{"name":"Department of Anatomy, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natjira","family":"Mana","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattarat","family":"Thangthamniyom","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ploypailin","family":"Semkum","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5595-3296","authenticated-orcid":true,"given":"Porntippa","family":"Lekcharoensuk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vudhiporn","family":"Limprasutr","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences","place":["Bangkok, Thailand"]},{"name":"Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-9764","authenticated-orcid":true,"given":"Sirin","family":"Theerawatanasirikul","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine","place":["Bangkok, Thailand"]},{"name":"Kasetsart University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/v15091847"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.3143"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.09.008"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.04.017"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2016.08.002"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s44149-021-00005-9"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104927"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19825701"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15780"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/v13112228"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.1002488"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.11.005"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17729626"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00907-22"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17187"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/med.21627"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.04.008"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29184475"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03347-21"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00512"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/v14112429"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211048647"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2022.01.005"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10080513"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.852210"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.023"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02685-15"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.12.012"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/v13112118"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)00026-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7348.1939.tb06990.x"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.149"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00181"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2015.09.001"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac382"},{"key":"ref36\/cit36","volume-title":"Guidance for Industry: Estimating the Maximum Safe Starting Dose in Adult Healthy Volunteer","author":"U.S. FDA","year":"2005"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.9.1880"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X241267181"},{"key":"ref40\/cit40","volume-title":"INVIRASE\u00ae (Saquinavir Mesylate) Capsules and Tablets","author":"U.S. Food and Drug Administration","year":"2010"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0223-6"},{"key":"ref42\/cit42","first-page":"1","volume-title":"Reference Module in Biomedical Sciences","author":"Furman B. L.","year":"2016"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00910"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.05.008"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61170-3"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2024.107301"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00118-4"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90699-1"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1850710"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.3c00446"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00197"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh487"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03681-20"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00110.x"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1675100"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.08.022"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2018.1437933"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12708"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12067"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2007.00902.x"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","volume-title":"Chemical Biology: Methods and Protocols","author":"Dallakyan S.","year":"2015","edition":"1"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2023.618-630"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00016","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:12:32Z","timestamp":1781251952000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.6c00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,12]]}},"alternative-id":["10.1021\/acsptsci.6c00016"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.6c00016","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}