{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:22:03Z","timestamp":1783689723874,"version":"3.55.0"},"reference-count":99,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100009633","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HD102786"],"award-info":[{"award-number":["R01HD102786"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2026,7,10]]},"DOI":"10.1021\/acsptsci.6c00131","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:19:07Z","timestamp":1782242347000},"page":"1893-1910","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of Renal Transporters by Pro-Inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9541-3199","authenticated-orcid":true,"given":"Yik Pui","family":"Tsang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3068-4077","authenticated-orcid":true,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]},{"name":"Kidney Research Institute","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingcheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jashvant D.","family":"Unadkat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Seattle, United States"]},{"name":"University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2432"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107627"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.143"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.431"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023630"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016907"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2010.00822.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.018747"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.123.002019"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmd.2025.100208"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.07.013"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2025.2525970"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140317"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2082055"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15102427"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020285"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmd.2025.100046"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v32.i1.30"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108760"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.122.000926"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.13073"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.79"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02048-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402800101"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01775-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309718110"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00620.2013"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00405"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1465625"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13314"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004431"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.302"},{"issue":"3","key":"ref34\/cit34","first-page":"207","volume":"29","author":"Morgan E. T.","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-113"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156594"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu621"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1051-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155323"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1770129"},{"issue":"5","key":"ref41\/cit41","first-page":"565","volume":"18","author":"Gr\u00f6ndal G.","year":"2000","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.4103\/ejim.ejim_92_18"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2018-000260"},{"issue":"3","key":"ref44\/cit44","first-page":"562","volume":"70","author":"Kim T.","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejr.2013.10.003"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.3.232"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90185-7"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902019000418551"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejr.2015.09.006"},{"issue":"6","key":"ref50\/cit50","first-page":"919","volume":"138","author":"Shen H.","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46030167"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903067378"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2605"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4989"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01036-5"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2024.2338742"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001163"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1080\/09629359890875"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704866"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.64"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110340"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0356-0"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.06.011"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/cells13121008"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152535"},{"issue":"3","key":"ref70\/cit70","first-page":"591","volume":"86","author":"Kreisberg J. I.","year":"1977","journal-title":"Am. J. Pathol."},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-08-0658"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00103.x"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/srep09167"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1310"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/nature10098"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020914"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000469"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2015.12.026"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.012112"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2023.116792"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01705-z"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1720013"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00145H"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123125"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01655-6"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223356"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222784"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1470488"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roae026"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.118.081307"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.75876"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.158"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01405-1"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703431"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.12.1330"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90586-X"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251194298"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2019.05.003"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00078"}],"container-title":["ACS Pharmacology & Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00131","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:43:48Z","timestamp":1783687428000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.6c00131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":99,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,10]]}},"alternative-id":["10.1021\/acsptsci.6c00131"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.6c00131","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}