{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:04Z","timestamp":1786724824467,"version":"build-2736575974"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22401293"],"award-info":[{"award-number":["22401293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204347"],"award-info":[{"award-number":["82204347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473778"],"award-info":[{"award-number":["82473778"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RAF dimerization is crucial for oncogenic signaling in RAS mutant tumors, contributing to resistance to mitogen-activated protein kinase pathway inhibitors by promoting dysregulated BRAF dimerization. This makes it a promising target for overcoming resistance caused by paradoxical extracellular signal-regulated kinase (ERK) signaling activation resulting from BRAF mutations (e.g., BRAFV600E) and inhibitors like vemurafenib and dabrafenib. Peptide inhibitors such as Braftide (TRHVNILLFM) block BRAF dimerization but lack cell permeability and biological activity within cells. A promising solution is conjugating cell-penetrating peptides (CPPs). However, this approach involves a trade-off: it produces a larger molecule and increases the level of off-target cytotoxicity. On the basis of the crystal structure of the BRAF homodimer, we developed a series of linear and cyclic peptides derived from Braftide. Among these peptides, CBF-2-2 crosses the cell membrane without the aid of CPPs and significantly inhibits tumor cell growth, exhibiting greater serum stability than Braftide. Moreover, the composite peptide SCBF-2-2, which contains an anti-invasion sequence, disrupts BRAF dimers, effectively inhibits cancer cell proliferation and invasion, reduces ERK phosphorylation, and suppresses tumor growth in the A549 mouse xenograft model. SCBF-2-2 offers a new starting point for developing dual-function antitumor peptides that target the BRAF dimer.<\/jats:p>","DOI":"10.1021\/acsptsci.6c00158","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:39:26Z","timestamp":1784198366000},"page":"2266-2281","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Cyclic Peptides Targeting the BRAF Dimer\nInterface as Dual Inhibitors"],"prefix":"10.1021","volume":"9","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]},{"name":"Department of Internal Medicine , No. 944 Hospital of Joint Logistics Support Force , ,","place":["Jiuquan, PR China, 735000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8571-8044","authenticated-orcid":true,"given":"Wen-Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0166-8110","authenticated-orcid":true,"given":"Peng","family":"Dong","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-5045","authenticated-orcid":true,"given":"Conghao","family":"Gai","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-9091","authenticated-orcid":true,"given":"Xiaoyun","family":"Chai","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Chengdu University , , ,","place":["Chengdu, PR China, 610106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Chengdu University , , ,","place":["Chengdu, PR China, 610106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu University , , ,","place":["Chengdu, PR China, 610106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-7275","authenticated-orcid":true,"given":"Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"Naval Medical University (Second Military Medical University) , , ,","place":["Shanghai, PR China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"3","key":"2026081411082397800_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN\nEstimates of Incidence and Mortality Worldwide for 36 Cancers in 185\nCountries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"issue":"4","key":"2026081411082397800_cit2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.apsb.2018.01.008","article-title":"Targeting ERK, an Achilles\u2019\nHeel of the MAPK Pathway, in Cancer Therapy","volume":"8","author":"Liu","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"9","key":"2026081411082397800_cit3","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.bbamcr.2010.12.012","article-title":"The MAPK Cascades:\nSignaling Components, Nuclear Roles and Mechanisms of Nuclear Translocation","volume":"1813","author":"Plotnikov","year":"2011","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"10","key":"2026081411082397800_cit4","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/cancers11101618","article-title":"A Comprehensive\nReview on MAPK: A Promising Therapeutic\nTarget in Cancer","volume":"11","author":"Braicu","year":"2019","journal-title":"Cancers"},{"issue":"3","key":"2026081411082397800_cit5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1177\/1947601911407323","article-title":"Raf Family Kinases: Old Dogs Have\nLearned New Tricks","volume":"2","author":"Matallanas","year":"2011","journal-title":"Genes Cancer"},{"issue":"11","key":"2026081411082397800_cit6","doi-asserted-by":"publisher","first-page":"9666","DOI":"10.3390\/ijms24119666","article-title":"MAPK-ERK\nPathway","volume":"24","author":"Park","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"2026081411082397800_cit7","doi-asserted-by":"publisher","first-page":"R563","DOI":"10.1016\/j.cub.2005.07.010","article-title":"Signaling Interplay in Ras Superfamily\nFunction","volume":"15","author":"Mitin","year":"2005","journal-title":"Curr. Biol."},{"issue":"7926","key":"2026081411082397800_cit8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/s41586-022-04928-2","article-title":"Structure\u2013Function\nAnalysis of the SHOC2\u2013MRAS\u2013PP1C Holophosphatase Complex","volume":"609","author":"Kwon","year":"2022","journal-title":"Nature"},{"issue":"5","key":"2026081411082397800_cit9","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.cell.2013.07.046","article-title":"Allosteric\nActivation of Functionally Asymmetric RAF Kinase Dimers","volume":"154","author":"Hu","year":"2013","journal-title":"Cell"},{"issue":"6","key":"2026081411082397800_cit10","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1128\/MCB.26.6.2262-2272.2006","article-title":"Regulation and Role\nof Raf-1\/B-Raf Heterodimerization","volume":"26","author":"Rushworth","year":"2006","journal-title":"Mol. Cell.\nBiol."},{"issue":"47","key":"2026081411082397800_cit11","doi-asserted-by":"publisher","first-page":"15609","DOI":"10.1039\/D1SC03444H","article-title":"The Mechanism of Raf\nActivation through Dimerization","volume":"12","author":"Zhang","year":"2021","journal-title":"Chem. Sci."},{"issue":"6","key":"2026081411082397800_cit12","doi-asserted-by":"publisher","first-page":"110351","DOI":"10.1016\/j.celrep.2022.110351","article-title":"CRAF Dimerization with ARAF Regulates KRAS-Driven Tumor Growth","volume":"38","author":"Venkatanarayan","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"2026081411082397800_cit13","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1158\/0008-5472.CAN-15-2900-T","article-title":"Secondary Tumors Arising in Patients\nUndergoing BRAF Inhibitor Therapy Exhibit Increased BRAF\u2013CRAF\nHeterodimerization","volume":"76","author":"Boussemart","year":"2016","journal-title":"Cancer Res."},{"issue":"6892","key":"2026081411082397800_cit14","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF Gene in Human\nCancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"issue":"4","key":"2026081411082397800_cit15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ccr.2004.09.022","article-title":"Guilty as charged: B-RAF is a human\noncogene","volume":"6","author":"Garnett","year":"2004","journal-title":"Cancer Cell"},{"issue":"21","key":"2026081411082397800_cit16","doi-asserted-by":"publisher","first-page":"8475","DOI":"10.1158\/0008-5472.CAN-10-0603","article-title":"BRAF inactivation\ndrives aneuploidy by deregulating\nCRAF","volume":"70","author":"Kamata","year":"2010","journal-title":"Cancer Res."},{"issue":"12","key":"2026081411082397800_cit17","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1158\/2159-8290.CD-14-0477","article-title":"Universes\nCollide: Combining Immunotherapy\nwith Targeted Therapy for Cancer","volume":"4","author":"Wargo","year":"2014","journal-title":"Cancer Discovery"},{"issue":"11","key":"2026081411082397800_cit18","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1172\/JCI76539","article-title":"BRAF Inhibitor\u2013Associated\nERK Activation Drives Development of Chronic Lymphocytic Leukemia","volume":"124","author":"Yaktapour","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"3","key":"2026081411082397800_cit19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ccr.2010.02.029","article-title":"The Raf Inhibitor Paradox: Unexpected Consequences\nof Targeted Drugs","volume":"17","author":"Cox","year":"2010","journal-title":"Cancer Cell"},{"issue":"7287","key":"2026081411082397800_cit20","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature08833","article-title":"RAF Inhibitors\nPrime Wild-Type RAF to Activate the MAPK Pathway and Enhance Growth","volume":"464","author":"Hatzivassiliou","year":"2010","journal-title":"Nature"},{"issue":"7287","key":"2026081411082397800_cit21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature08902","article-title":"RAF Inhibitors\nTransactivate RAF Dimers and ERK Signalling in Cells with Wild-Type\nBRAF","volume":"464","author":"Poulikakos","year":"2010","journal-title":"Nature"},{"issue":"3","key":"2026081411082397800_cit22","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ccell.2015.08.001","article-title":"BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms\nThat Determine Their Sensitivity to Pharmacologic Inhibition","volume":"28","author":"Yao","year":"2015","journal-title":"Cancer Cell"},{"issue":"11","key":"2026081411082397800_cit23","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1038\/emboj.2012.100","article-title":"Distinct Requirement\nfor an Intact Dimer Interface in Wild-Type, V600E and Kinase-Dead\nB-Raf Signalling: V600E and G469A B-Raf Are Potent Homodimerisers","volume":"31","author":"Ro\u0308ring","year":"2012","journal-title":"EMBO J."},{"key":"2026081411082397800_cit24","doi-asserted-by":"publisher","first-page":"102205","DOI":"10.1016\/j.cbpa.2022.102205","article-title":"Mechanism and Inhibition of BRAF\nKinase","volume":"71","author":"Gunderwala","year":"2022","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"4","key":"2026081411082397800_cit25","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.molcel.2012.12.018","article-title":"Effects of Raf Dimerization\nand Its\nInhibition on Normal and Disease-Associated Raf Signaling","volume":"49","author":"Freeman","year":"2013","journal-title":"Mol. Cell"},{"issue":"7","key":"2026081411082397800_cit26","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1021\/acschembio.9b00191","article-title":"Development\nof Allosteric BRAF Peptide Inhibitors Targeting the Dimer Interface\nof BRAF","volume":"14","author":"Gunderwala","year":"2019","journal-title":"ACS Chem. Biol."},{"issue":"8","key":"2026081411082397800_cit27","doi-asserted-by":"publisher","first-page":"3886","DOI":"10.1021\/acs.jmedchem.8b01288","article-title":"Design and\nSynthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization\nand Overcome Paradoxical MEK\/ERK Activation","volume":"62","author":"Beneker","year":"2019","journal-title":"J. Med. Chem."},{"key":"2026081411082397800_cit28","doi-asserted-by":"publisher","first-page":"129627","DOI":"10.1016\/j.bmcl.2024.129627","article-title":"Further Structural\nOptimization and SAR Study of Sungsanpin Derivatives as Cell-Invasion\nInhibitors","volume":"99","author":"Chen","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"2026081411082397800_cit29","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1021\/acs.jmedchem.4c00065","article-title":"Cyclic Peptide Keap1\u2013Nrf2\nProtein\u2013Protein Interaction\nInhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung\nInjury","volume":"67","author":"Zou","year":"2024","journal-title":"J. Med. Chem."},{"issue":"4","key":"2026081411082397800_cit30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.tips.2017.01.003","article-title":"Cell-Penetrating Peptides: From Basic\nResearch to Clinics","volume":"38","author":"Guidotti","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"2026081411082397800_cit31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13046-021-01967-x","article-title":"A Review of\nthe Biological and Clinical Implications of RAS-MAPK Pathway Alterations\nin Neuroblastoma","volume":"40","author":"Mlakar","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"2026081411082397800_cit32","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3892\/etm.2020.8454","article-title":"ERK\/MAPK signalling\npathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"23","key":"2026081411082397800_cit33","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1007\/s00018-016-2297-8","article-title":"Negative Feedback Regulation of the\nERK1\/2 MAPK Pathway","volume":"73","author":"Lake","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"2026081411082397800_cit34","doi-asserted-by":"publisher","first-page":"15444","DOI":"10.18632\/aging.203102","article-title":"Alterations in the\nRTK\/Ras\/PI3K\/AKT Pathway Serve as Potential Biomarkers for Immunotherapy\nOutcome of Diffuse Gliomas","volume":"13","author":"Han","year":"2021","journal-title":"Aging"},{"issue":"7377","key":"2026081411082397800_cit35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nature10662","article-title":"RAF Inhibitor Resistance\nIs Mediated by Dimerization of Aberrantly Spliced BRAF(V600E)","volume":"480","author":"Poulikakos","year":"2011","journal-title":"Nature"},{"issue":"11","key":"2026081411082397800_cit36","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1038\/nm.3392","article-title":"Tumor Adaptation and Resistance to\nRAF Inhibitors","volume":"19","author":"Lito","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"2026081411082397800_cit37","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ccr.2010.10.031","article-title":"AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine\nKinase Expression and Activity","volume":"19","author":"Chandarlapaty","year":"2011","journal-title":"Cancer Cell"},{"issue":"34","key":"2026081411082397800_cit38","doi-asserted-by":"publisher","first-page":"31099","DOI":"10.1074\/jbc.M111974200","article-title":"Regulation of Raf-Akt Cross-Talk","volume":"277","author":"Moelling","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"2026081411082397800_cit39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","article-title":"Akt Phosphorylation of BAD Couples\nSurvival Signals to the Cell-Intrinsic Death Machinery","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"issue":"9","key":"2026081411082397800_cit40","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.3390\/ijms20092188","article-title":"PI3K\/AKT\/mTOR Signaling Regulates\nthe Virus\/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells","volume":"20","author":"Bossler","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026081411082397800_cit41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41417-023-00682-3","article-title":"HPV E6\/E7:\ninsights\ninto their regulatory role and mechanism in signaling pathways in\nHPV-associated tumor","volume":"31","author":"Peng","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"2026081411082397800_cit42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2012.12.007","article-title":"Key Molecular Mechanisms in Lung\nCancer Invasion and Metastasis: A Comprehensive Review","volume":"87","author":"Perlikos","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"2026081411082397800_cit43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.matbio.2015.03.005","article-title":"The Role\nof TIMPs in Regulation of\nExtracellular Matrix Proteolysis","volume":"44\u201346","author":"Arpino","year":"2015","journal-title":"Matrix Biol."},{"key":"2026081411082397800_cit44","doi-asserted-by":"publisher","first-page":"115231","DOI":"10.1016\/j.ejmech.2023.115231","article-title":"Design, synthesis and\ncharacterisation of a novel type II B-RAF paradox breaker inhibitor","volume":"250","author":"Arora","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"2026081411082397800_cit45","doi-asserted-by":"publisher","first-page":"2025.02.17.637148","DOI":"10.1101\/2025.02.17.637148","article-title":"Targeting the Protein-Protein\nInteraction Between the CDC37 Co-Chaperone\nand Client Kinases by an Allosteric RAF Dimer Breaker","author":"Yu","year":"2025","journal-title":"bioRxiv"},{"issue":"9","key":"2026081411082397800_cit46","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41419-024-07073-y","article-title":"Treating\nICB-Resistant Cancer by Inhibiting PD-L1 via DHHC3 Degradation Induced\nby Cell Penetrating Peptide-Induced Chimera Conjugates","volume":"15","author":"Shi","year":"2024","journal-title":"Cell Death Dis."}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00158","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/8\/2266\/65973117\/acsptsci.6c00158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/8\/2266\/65973117\/acsptsci.6c00158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:28:14Z","timestamp":1786721294000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article\/9\/8\/2266\/5211806\/Discovery-of-Cyclic-Peptides-Targeting-the-BRAF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,16]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsptsci.6c00158","relation":{},"ISSN":["2575-9108"],"issn-type":[{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]}}}