{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:06:46Z","timestamp":1789135606922,"version":"build-2803163510"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","award":["EFA031\/01 NEURO-COOP"],"award-info":[{"award-number":["EFA031\/01 NEURO-COOP"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PDC2025-165940-I00"],"award-info":[{"award-number":["PDC2025-165940-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2024-160022OB-I00"],"award-info":[{"award-number":["PID2024-160022OB-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci?n","doi-asserted-by":"publisher","award":["PDC2025-165940-I00"],"award-info":[{"award-number":["PDC2025-165940-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci?n","doi-asserted-by":"publisher","award":["PID2024-160022OB-I00"],"award-info":[{"award-number":["PID2024-160022OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Procerones are highly brominated marine natural products that were isolated in 2019 from Polycarpa procera. Herein, we report the first total syntheses of procerones A and B, together with their enantiomers, in only three linear steps, starting from commercially available acetophenone and benzaldehyde derivatives. The synthesis takes advantage of a chalcone core structure obtained by Aldol condensation followed by Davis oxidation to implement the chiral \u03b1-hydroxy ketone moiety without the use of heavy metals. The effects of all synthesized compounds, including the enantiopure natural products, on the major inhibitory neurotransmitter receptor in the mammalian brain (GABAA receptor) were determined, and the four enantiopure procerones were additionally tested for antiprion activity. While no antiprion activity was observed for the tested compounds, one unprecedented precursor, as well as procerone B and its enantiomer, significantly enhanced GABAA receptor function, suggesting that this scaffold may serve as a starting point for developing novel GABAA receptor modulators.<\/jats:p>","DOI":"10.1021\/acsptsci.6c00196","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:48:25Z","timestamp":1787431705000},"page":"2525-2534","source":"Crossref","is-referenced-by-count":0,"title":["Concise Total Synthesis\nand Pharmacological Evaluation\nof Procerones A and B"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8975-3222","authenticated-orcid":true,"given":"Jasmin","family":"Janneschu\u0308tz","sequence":"first","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia B.","family":"Gartlgruber","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phila","family":"Weissenstein","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Aczel","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz M.","family":"Herkner","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Shtepani","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Haller","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Bacowsky","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Aslam","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureta","family":"Gashi","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-4211","authenticated-orcid":true,"given":"Hasier","family":"Eran\u0303a","sequence":"additional","affiliation":[{"name":"Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA) , Bizkaia Technology Park , ,","place":["Derio, Spain, 48160"]},{"name":"ATLAS Molecular Pharma S. L. , Bizkaia Technology Park , ,","place":["Derio, Spain, 48160"]},{"name":"Carlos III National Health Institute , , C\/Monforte de Lemos 3-5 , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3239-3868","authenticated-orcid":true,"given":"Juan C.","family":"Fuentes-Monteverde","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Multidisciplinary Sciences , , Am Fassberg 11 , ,","place":["Go\u0308ttingen, Germany, 37077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Abel","sequence":"additional","affiliation":[{"name":"Philipps-Universita\u0308t Marburg , , Marbacher Weg 6-10 , ,","place":["Marburg, Germany, 35032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6228-2883","authenticated-orcid":true,"given":"Stefan","family":"Simic\u0301","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]},{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wackerlig-Damle","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Gru\u0308nweller","sequence":"additional","affiliation":[{"name":"Philipps-Universita\u0308t Marburg , , Marbacher Weg 6-10 , ,","place":["Marburg, Germany, 35032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-4344","authenticated-orcid":true,"given":"Christian","family":"Griesinger","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Multidisciplinary Sciences , , Am Fassberg 11 , ,","place":["Go\u0308ttingen, Germany, 37077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqui\u0301n","family":"Castilla","sequence":"additional","affiliation":[{"name":"Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA) , Bizkaia Technology Park , ,","place":["Derio, Spain, 48160"]},{"name":"Carlos III National Health Institute , , C\/Monforte de Lemos 3-5 , ,","place":["Madrid, Spain, 28029"]},{"name":"IKERBASQUE, Basque Foundation for Science, Prion Research Lab , Plaza Euskadi 5 , ,","place":["Bilbao, Spain, 48009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-8973","authenticated-orcid":true,"given":"Sophia","family":"Khom","sequence":"additional","affiliation":[{"name":"University of Vienna , , Josef-Holaubek-Platz 2 , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-0057","authenticated-orcid":true,"given":"Nina","family":"Schu\u0308tzenmeister","sequence":"additional","affiliation":[{"name":"Philipps-Universita\u0308t Marburg , , Marbacher Weg 6-10 , ,","place":["Marburg, Germany, 35032"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"issue":"12","key":"2026091109132589300_cit1","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.4155\/fmc.11.118","article-title":"Marine Natural Products: A New Wave of Drugs?","volume":"3","author":"Montaser","year":"2011","journal-title":"Future Med. 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Asymmetric Oxidation\nof Organosulfur Compounds Using Chiral 2-Sulfonyloxaziridines","volume":"104","author":"Davis","year":"1982","journal-title":"J. Am. Chem. Soc."},{"issue":"18","key":"2026091109132589300_cit17","doi-asserted-by":"publisher","first-page":"6679","DOI":"10.1021\/ja00174a035","article-title":"Chemistry of Oxaziridines.\n14. Asymmetric Oxidation of Ketone Enolates Using Enantiomerically\nPure (Camphorylsulfonyl)Oxaziridine","volume":"112","author":"Davis","year":"1990","journal-title":"J. Am.\nChem. Soc."},{"issue":"5","key":"2026091109132589300_cit18","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1021\/cr00013a008","article-title":"Asymmetric Hydroxylation of Enolates with N-Sulfonyloxaziridines","volume":"92","author":"Davis","year":"1992","journal-title":"Chem. 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