{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:09:09Z","timestamp":1789135749307,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["310880\/2022-0"],"award-info":[{"award-number":["310880\/2022-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008532","name":"Universidade Federal do Rio Grande do Norte","doi-asserted-by":"publisher","award":["03\/2018"],"award-info":[{"award-number":["03\/2018"]}],"id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Topiramate is a widely prescribed antiepileptic drug with a multimodal mechanism of action. However, its effects on male reproductive function remain poorly characterized. This study was conducted to investigate the impact of this drug on testicular and epididymal function in adult male Wistar rats. Animals were treated orally for 21 days with topiramate at 40 or 160 mg\/kg. Serum testosterone levels, testicular histomorphology, spermatogenic indices, sperm parameters, and epididymal duct contractility were subsequently evaluated. The treatment did not alter serum testosterone levels at either dose. However, both doses reduced Sertoli cell and round spermatid numbers, increased primary spermatocyte counts, and decreased meiotic and overall spermatogenic yields, whereas only the higher dose (160 mg\/kg) reduced Sertoli cell efficiency and daily sperm production. The lower dose (40 mg\/kg) increased sperm morphological abnormalities, whereas the higher dose reduced total and progressive sperm motility and induced both head and tail defects. Additionally, treatment with topiramate at 160 mg\/kg prolonged sperm transit time in the cauda epididymis and reduced contractile responses of the distal cauda epididymal duct to KCl, noradrenaline, and carbachol, suggesting impaired epididymal transport and potential ejaculatory dysfunction. Altogether, these findings demonstrate that topiramate adversely affects male reproductive function. Given its widespread use in individuals of reproductive age, these results underscore the need for translational studies in humans to assess potential reproductive risks associated with this therapy.<\/jats:p>","DOI":"10.1021\/acsptsci.6c00273","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T15:01:59Z","timestamp":1786806119000},"page":"2595-2605","source":"Crossref","is-referenced-by-count":0,"title":["Topiramate Impairs\nSpermatogenesis, Sperm Parameters,\nand Epididymal Duct Contractility in Rats"],"prefix":"10.1021","volume":"9","author":[{"given":"Maele Oliveira de","family":"Sena","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Santana da","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanka do Vale","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9833-6948","authenticated-orcid":true,"given":"Herick Jose","family":"Cunha Chaves","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Leti\u0301cia da","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna da Silva","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Nazareno Gomes de","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Souza e","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Expedito Silva","family":"do Nascimento Junior","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Karynna Alves de Alencar","family":"Rocha","sequence":"additional","affiliation":[{"name":"Mauri\u0301cio de Nassau University Center , ,","place":["Natal, Rio Grande do Norte, Brazil, 59080-400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Cristina","family":"Gavioli","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-8056","authenticated-orcid":true,"given":"Edilson Dantas","family":"da Silva Junior","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte , , , ,","place":["Natal, Rio Grande do Norte, Brazil, 59072-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"2026091109131859700_cit1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aju.2017.12.004","article-title":"Lifestyle\ncauses of male infertility","volume":"16","author":"Durairajanayagam","year":"2018","journal-title":"Arab J. 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Reprod. Update"},{"key":"2026091109131859700_cit50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fendo.2018.00059","article-title":"Characteristics\nof\nthe epididymal luminal environment responsible for sperm maturation\nand storage","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Endocrinol."},{"key":"2026091109131859700_cit51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1528-1157.2000.tb06047.x","article-title":"Topiramate\nas an in-hibitor of carbonic\nanhydrase isoenzymes","volume":"41","author":"Dodgson","year":"2000","journal-title":"Epilepsia"},{"key":"2026091109131859700_cit52","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/molehr\/5.3.199","article-title":"Novel transcripts\nof carbonic anhydrase\nII in mouse and human testis","volume":"5","author":"Mezquita","year":"1999","journal-title":"Mol. Hum. 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