{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:52:52Z","timestamp":1791553972748,"version":"4.3.4"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd."},{"name":"Darwin Nuogao (Beijing) Biotechnology Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Knee osteoarthritis (KOA) has no effective nonsurgical treatment. Intra-articular therapy constitutes an effective localized intervention; however, persistent lymphatic drainage and synovial vascular exchange lead to rapid drug elimination. Encapsulating bioactive agents into microsphere delivery platforms enables localized intra-articular administration, with their scaffold-based spherical architecture serving as pharmaceutical and cellular carriers or tissue engineering scaffolds, representing a highly promising therapeutic avenue for KOA. Herein, PLGA was employed to prepare microspheres and a sustained-release microsphere formulation (MPs PLGA DSP@COLI) was prepared for KOA therapeutics, co-encapsulating type I collagen (COLI) and dexamethasone sodium phosphate (DSP). Characterization revealed uniform particle size distribution, favorable dispersibility, and extended-release kinetics. Functional assessments demonstrated robust anti-inflammatory efficacy and enhanced chondrocyte-mediated extracellular matrix deposition. Histopathological and immunohistochemical analyses demonstrated preserved cartilage matrix integrity, augmented COLII synthesis, diminished inflammatory cellular infiltration, and maintained homeostasis of cartilage matrix components, concomitant with reduced OARSI and synovitis scores. These effects collectively suppressed synovial hyperplasia and inflammation and suggested potential improvement in joint conditions. Overall, MPs PLGA DSP@COLI combines the pharmacological anti-inflammatory properties of DSP with the extracellular matrix-related biological functions of COLI, establishing an innovative \u201cdrug-device combination\u201d therapeutic paradigm, which represents a promising therapeutic strategy for KOA.<\/jats:p>","DOI":"10.1021\/acsptsci.6c00389","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:02:05Z","timestamp":1790049725000},"page":"2910-2927","source":"Crossref","is-referenced-by-count":0,"title":["Microsphere System\nColoading Type I Collagen and Dexamethasone\nSodium Phosphate for Osteoarthritis Therapy"],"prefix":"10.1021","volume":"9","author":[{"given":"Xianlan","family":"Chen","sequence":"first","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]},{"name":"Darwin Nuogao (Beijing) Biotechnology Co., Ltd. , ,","place":["Beijing, People\u2019s Republic of China, 100006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Chi","sequence":"additional","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]},{"name":"Darwin Nuogao (Beijing) Biotechnology Co., Ltd. , ,","place":["Beijing, People\u2019s Republic of China, 100006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Hu","sequence":"additional","affiliation":[{"name":"Soochow University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Soochow University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-5872","authenticated-orcid":true,"given":"Mi","family":"Liu","sequence":"additional","affiliation":[{"name":"Suzhou University , , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215123"]},{"name":"Soochow University , , ,","place":["Suzhou, People\u2019s Republic of China, 215123"]},{"name":"Suzhou Ersheng Biopharmaceutical Co., Ltd. , , ,","place":["Suzhou, Jiangsu, People\u2019s Republic of China, 215000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"9","key":"2026100909102069600_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/s2665-9913(23)00163-7","article-title":"Global,\nregional, and national burden of osteoarthritis, 1990\u20132020\nand projections to 2050: a systematic analysis for the Global Burden\nof Disease Study 2021","volume":"5","author":"GBD 2021 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Healthcare Mater."},{"issue":"6","key":"2026100909102069600_cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0320115","article-title":"Global burden of knee osteoarthritis from 1990 to 2021: Trends, inequalities,\nand projections to 2035","volume":"20","author":"Chen","year":"2025","journal-title":"PLoS One"},{"issue":"6","key":"2026100909102069600_cit31","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00270-020-02764-3","article-title":"Genicular artEry embolizatioN in patiEnts with oSteoarthrItiS\nof the Knee (GENESIS) Using Permanent Microspheres: Interim Analysis","volume":"44","author":"Little","year":"2021","journal-title":"Cardiovasc. Interventional Radiol."},{"issue":"18","key":"2026100909102069600_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517083","article-title":"Injectable\nChondroitin Sulfate Methacrylate Hydrogel Microspheres\nCo-Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic\nOsteoarthritis Therapy","volume":"13","author":"Feng","year":"2026","journal-title":"Adv. Sci."},{"issue":"4","key":"2026100909102069600_cit33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/ijms17040411","article-title":"Intra-Articular\nInjection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates\nOsteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"2026100909102069600_cit34","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.3390\/nu15061332","article-title":"Collagen Supplementation\nfor Joint Health: The Link between Composition and Scientific Knowledge","volume":"15","author":"Marti\u0301nez-Puig","year":"2023","journal-title":"Nutrients"},{"issue":"9","key":"2026100909102069600_cit35","doi-asserted-by":"publisher","first-page":"5632","DOI":"10.1021\/acsbiomaterials.4c00669","article-title":"Type-I Collagen\nPolypeptide-Based Composite Nanofiber Membranes for Fast and Efficient\nBone Regeneration","volume":"10","author":"Jin","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"2026100909102069600_cit36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41565-025-02101-0","article-title":"A disease-severity-responsive\nnanoparticle enables\npotent ghrelin messenger RNA therapy in osteoarthritis","volume":"21","author":"Dewani","year":"2026","journal-title":"Nat. Nanotechnol."},{"issue":"8","key":"2026100909102069600_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70290","article-title":"Osteoarthritis:\nMechanisms and Therapeutic Advances","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm\n(2020)"},{"issue":"5","key":"2026100909102069600_cit38","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.apsb.2019.01.015","article-title":"Kinsenoside attenuates osteoarthritis\nby repolarizing macrophages through inactivating NF-\u03baB\/MAPK\nsignaling and protecting chondrocytes","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta\nPharm. Sin B"},{"issue":"1","key":"2026100909102069600_cit39","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.joca.2004.10.011","article-title":"Retroviral\ntransduction with SOX9 enhances re-expression of the chondrocyte phenotype\nin passaged osteoarthritic human articular chondrocytes","volume":"13","author":"Tew","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2026100909102069600_cit40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines\nin the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat.\nRev. Rheumatol."},{"key":"2026100909102069600_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514752","article-title":"Intra-Articular Injectable Hydrogel\nMicrosphere-Based Drug Delivery System for Osteoarthritis Treatment","volume":"22","author":"Zhang","year":"2026","journal-title":"Small"},{"key":"2026100909102069600_cit42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis:\ncomparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026100909102069600_cit43","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between\nchronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"}],"container-title":["ACS Pharmacology &amp; Translational\nScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00389","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/10\/2910\/68589055\/acsptsci.6c00389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/10\/2910\/68589055\/acsptsci.6c00389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:31:29Z","timestamp":1791552689000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article\/9\/10\/2910\/5434794\/Microsphere-System-Coloading-Type-I-Collagen-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,21]]},"published-print":{"date-parts":[[2026,10,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsptsci.6c00389","relation":{},"ISSN":["2575-9108"],"issn-type":[{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}