{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:53:06Z","timestamp":1791553986734,"version":"4.3.4"},"reference-count":12,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL169530"],"award-info":[{"award-number":["R01HL169530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.<\/jats:p>","DOI":"10.1021\/acsptsci.6c00552","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:17Z","timestamp":1789653737000},"page":"3000-3004","source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotection\nIs a Delivery Problem: A First-Medical-Contact\nFramework for Acute Myocardial Infarction"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3611-9009","authenticated-orcid":true,"given":"Vibhudutta","family":"Awasthi","sequence":"first","affiliation":[{"name":"University of Oklahoma College of Pharmacy , , 1110 North Stonewall Avenue , , ,","place":["Oklahoma City, Oklahoma, United States, 73117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun W.","family":"Dasari","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Medicine , , 800 Stanton L. Young Blvd. , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi A.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Campus , , 920 Stanton L. Young Blvd. , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"12","key":"2026100909105684900_cit1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial\nischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"2026100909105684900_cit2","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1056\/NEJMoa1505489","article-title":"Cyclosporine before PCI in Patients with Acute\nMyocardial Infarction","volume":"373","author":"Cung","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"2026100909105684900_cit3","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/eurheartj\/ehv597","article-title":"EMBRACE STEMI study:\na Phase 2a trial to evaluate the safety, tolerability, and efficacy\nof intravenous MTP-131 on reperfusion injury in patients undergoing\nprimary percutaneous coronary intervention","volume":"37","author":"Gibson","year":"2016","journal-title":"Eur. Heart J."},{"issue":"10207","key":"2026100909105684900_cit4","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(19)32039-2","article-title":"Effect of remote ischaemic conditioning on clinical\noutcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI):\na single-blind randomised controlled trial","volume":"394","author":"Hausenloy","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"2026100909105684900_cit5","first-page":"633","article-title":"The \u2033wavefront phenomenon\u2033\nof myocardial\nischemic cell death. II. Transmural progression of necrosis within\nthe framework of ischemic bed size (myocardium at risk) and collateral\nflow","volume":"40","author":"Reimer","year":"1979","journal-title":"Lab. Invest."},{"issue":"14","key":"2026100909105684900_cit6","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1161\/CIRCULATIONAHA.113.003653","article-title":"Effect\nof early metoprolol\non infarct size in ST-segment-elevation myocardial infarction patients\nundergoing primary percutaneous coronary intervention: the Effect\nof Metoprolol in Cardioprotection During an Acute Myocardial Infarction\n(METOCARD-CNIC) trial","volume":"128","author":"Ibanez","year":"2013","journal-title":"Circulation"},{"issue":"7","key":"2026100909105684900_cit7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132451","article-title":"A New Therapeutic Modality for Acute Myocardial\nInfarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces\nCardioprotection from Ischemia-Reperfusion Injury via Activation of\nPI3K\/Akt Pathway and Anti-Inflammation in a Rat Model","volume":"10","author":"Nagaoka","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2026100909105684900_cit8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget Strategies to Reduce Myocardial\nIschemia\/Reperfusion Injury: JACC Review Topic of the Week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"2026100909105684900_cit9","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against\ncardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"26","key":"2026100909105684900_cit10","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and Safety of Low-Dose Colchicine\nafter Myocardial Infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"2026100909105684900_cit11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019521","article-title":"Nanoparticle-Mediated\nSimultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates\nMyocardial Ischemia-Reperfusion Injury","volume":"10","author":"Ikeda","year":"2021","journal-title":"J. Am.\nHeart Assoc."},{"issue":"7527","key":"2026100909105684900_cit12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation\nof succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"}],"container-title":["ACS Pharmacology &amp; Translational\nScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.6c00552","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/10\/3000\/68544964\/acsptsci.6c00552.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article-pdf\/9\/10\/3000\/68544964\/acsptsci.6c00552.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:31:47Z","timestamp":1791552707000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aptsfn\/article\/9\/10\/3000\/5432059\/Cardioprotection-Is-a-Delivery-Problem-A-First"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,10,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsptsci.6c00552","relation":{},"ISSN":["2575-9108"],"issn-type":[{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}