{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:23:00Z","timestamp":1790522580792,"version":"4.1.0"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1072113"],"award-info":[{"award-number":["APP1072113"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136889"],"award-info":[{"award-number":["APP1136889"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006597","name":"Florida State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","award":["UQECR1945637"],"award-info":[{"award-number":["UQECR1945637"]}],"id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000155","name":"Division of Environmental Biology","doi-asserted-by":"publisher","award":["DEB-1638902"],"award-info":[{"award-number":["DEB-1638902"]}],"id":[{"id":"10.13039\/100000155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2020,2,14]]},"DOI":"10.1021\/acsptsci.9b00079","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T08:46:37Z","timestamp":1574671597000},"page":"119-134","source":"Crossref","is-referenced-by-count":22,"title":["Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na<sub>V<\/sub>1.1 Provide Novel Leads for Development of Antiepileptic Drugs"],"prefix":"10.1021","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-5843","authenticated-orcid":true,"given":"Chun Yuen","family":"Chow","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni K.-Y.","family":"Chin","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodong","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda V.","family":"Blomster","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaiah J.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, Florida 32306, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Herzig","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin R.","family":"Rokyta","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, Florida 32306, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2308-2200","authenticated-orcid":true,"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.224204"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.021"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.09.017"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411131111"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.046"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.062323"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5270-06.2007"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nn1754"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804764115"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.621940"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180762"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz125"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.09.023"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2741\/4121"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103501108"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031860"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5200-6"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01174-3"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.118.3.291"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2018.06.077"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2017.12.042"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2018.07.030"},{"key":"ref23\/cit23","unstructured":"Krueger, F. (2017)  Babraham Bioinformatics Trim Galore, version 0.4.4; www.bioinformatics.babraham.ac.uk\/projects\/trim_galore\/."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt593"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-312"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1883"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu077"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)02024-2"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.3.282"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7072494"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.063321"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.T600050-MCP200"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063865"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6887-9_10"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011254402785"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0607-467"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20449"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-009-9333-z"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-809-9:353"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5350"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5122456"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2534-2"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2344-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.04.006"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2018.10.022"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560040805"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bi0519248"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.00395.x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/bi961497l"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.05.009"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/cb400012k"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08545.x"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nature07473"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2493"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.230"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.03.011"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/srep04509"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614728114"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/srep40883"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00736"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.09.029"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7761"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/nature17976"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2122851"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500165"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.014"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/cn500171p"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0099-2"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.03.011"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2999"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau2486"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.4161\/chan.2.2.6022"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.09.006"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.04.337"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5452"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.04.336"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10010015"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau4640"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9297"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/nature10607"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.014"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.18869\/mjiri.31.27"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2018.07.007"}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.9b00079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:52:58Z","timestamp":1681440778000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.9b00079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2,14]]}},"alternative-id":["10.1021\/acsptsci.9b00079"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.9b00079","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]}}}