{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:58:28Z","timestamp":1790758708332,"version":"4.1.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2020-NR049568"],"award-info":[{"award-number":["RS-2020-NR049568"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2022-00165505"],"award-info":[{"award-number":["RS-2022-00165505"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cantilever-based biosensors provide a powerful approach for monitoring cardiomyocyte contractility, but conventional designs often exhibit baseline bending that compromises sensitivity and limits predictive accuracy in drug screening. Here, we present a tri-layer polymer cantilever biosensing platform integrated with a full-bridge piezoresistive strain sensor for the quantitative measurement of cardiomyocyte contractility. The hybrid KMSF\u2013SU-8\u2013KMSF structure minimizes residual stress and reduces baseline deformation by more than 85% compared to SU-8-only cantilevers. This architecture improves strain transfer to the embedded sensors and achieves a limit of detection of approximately 1.2 kPa, which is lower than that of previously reported cantilever systems. The top KMSF layer functions as both an encapsulation barrier and a tissue-guiding interface, promoting alignment, enhancing sarcomere organization, and increasing connexin-43 expression to support cardiomyocyte maturation. Drug screening further confirms the platform\u2019s predictive accuracy, as the device successfully detects the expected pharmacological effects: verapamil decreases contractile force, isoproterenol increases both force and beat rate, blebbistatin suppresses myofilament activity, and astemizole induces arrhythmic beating consistent with hERG channel blockade. By providing stable, label-free, and high-sensitivity electronic readouts of cardiomyocyte contractility, this platform establishes a robust and scalable solution for preclinical cardiotoxicity testing, disease modeling, and personalized medicine.<\/jats:p>","DOI":"10.1021\/acssensors.6c01331","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:43:06Z","timestamp":1788244986000},"page":"8032-8041","source":"Crossref","is-referenced-by-count":0,"title":["Strain Sensor\u2013Integrated Tri-Layer Cantilever with Enhanced Sensitivity and Stability for Quantitative Cardiotoxicity Screening"],"prefix":"10.1021","volume":"11","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunkumar","family":"Shanmugasundaram","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]},{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolan","family":"Sun","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Li","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9345-4217","authenticated-orcid":true,"given":"Gowoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Young","family":"Ko","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung-Sam","family":"Kim","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3191-4222","authenticated-orcid":true,"given":"Bong-Kee","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6624-6949","authenticated-orcid":true,"given":"Dong-Weon","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]},{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]},{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026092919093336300_cit1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.bioactmat.2024.11.037","article-title":"Integrating Melt Electrospinning Writing and Microfluidics To Engineer a Human Cardiac Microenvironment for High-Fidelity Drug Screening","volume":"45","author":"Wang","year":"2025","journal-title":"Bioact. 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