{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:34:11Z","timestamp":1773210851748,"version":"3.50.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007062","name":"Yangzhou University","doi-asserted-by":"publisher","award":["5021\/137012629"],"award-info":[{"award-number":["5021\/137012629"]}],"id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220591"],"award-info":[{"award-number":["BK20220591"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["32125002"],"award-info":[{"award-number":["32125002"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200051"],"award-info":[{"award-number":["32200051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32522004"],"award-info":[{"award-number":["32522004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Fund for Independent Innovation of Agricultural Sciences in Jiangsu Province","award":["CX [21]1004"],"award-info":[{"award-number":["CX [21]1004"]}]},{"name":"New Cornerstone Science Foundation","award":["NCI2002321"],"award-info":[{"award-number":["NCI2002321"]}]},{"name":"the Advanced Manufacturing and Engineering Programmatic Grant","award":["A18A9b0060"],"award-info":[{"award-number":["A18A9b0060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Synth. Biol."],"published-print":{"date-parts":[[2026,2,20]]},"DOI":"10.1021\/acssynbio.5c00890","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T11:49:46Z","timestamp":1770378586000},"page":"822-833","source":"Crossref","is-referenced-by-count":0,"title":["Enzymatic Synthesis of 2-Amino-adenosine Triphosphate as a Noncanonical Nucleotide Precursor of Z-Modified RNA"],"prefix":"10.1021","volume":"15","author":[{"given":"Junpeng","family":"Jia","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Agency for Science, Technology and Research (A*STAR), Singapore Institute of Food and Biotechnology Innovation (SIFBI), 31 Biopolis Way, Nanos, Singapore 138669, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-4399","authenticated-orcid":true,"given":"Jason","family":"Tan","sequence":"additional","affiliation":[{"name":"Agency for Science, Technology and Research (A*STAR), Singapore Institute of Food and Biotechnology Innovation (SIFBI), 31 Biopolis Way, Nanos, Singapore 138669, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Hu","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, School of Pharmaceutical Science and Technology","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Tong","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, School of Pharmaceutical Science and Technology","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinan","family":"Jiao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-0631","authenticated-orcid":true,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, School of Pharmaceutical Science and Technology","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]},{"name":"Frontiers Science Center for Synthetic Biology (Ministry of Education)","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]},{"name":"Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]},{"name":"School of Life Sciences and Biotechnology","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-4859","authenticated-orcid":true,"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses","place":["Yangzhou, China"]},{"name":"Yangzhou University","place":["Yangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe4882"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe6542"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/270369a0"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00114"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01111-19"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2308415120"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.11.5115"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/bit.28642"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106493108"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(78)90104-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25064-x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22626-x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe6494"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01410-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00369"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200295"},{"issue":"12","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1093\/nar\/19.12.3193","volume":"19","author":"Lamm G. M.","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1977.tb11239.x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202500241"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC03769C"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107739"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48012-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17505"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi0607498"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.186"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC00426E"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/c1nj20393b"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0971"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190005"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2018.02.002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/bi701009y"}],"container-title":["ACS Synthetic Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acssynbio.5c00890","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acssynbio.5c00890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:51:01Z","timestamp":1773132661000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acssynbio.5c00890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,20]]}},"alternative-id":["10.1021\/acssynbio.5c00890"],"URL":"https:\/\/doi.org\/10.1021\/acssynbio.5c00890","relation":{},"ISSN":["2161-5063","2161-5063"],"issn-type":[{"value":"2161-5063","type":"print"},{"value":"2161-5063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}