{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:42:12Z","timestamp":1791052932204,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acc. Chem. Res."],"published-print":{"date-parts":[[2001,5,1]]},"DOI":"10.1021\/ar000082w","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:58:40Z","timestamp":1027659520000},"page":"399-408","source":"Crossref","is-referenced-by-count":90,"title":["Enzymology, Structure, and Dynamics of Acetohydroxy Acid Isomeroreductase"],"prefix":"10.1021","volume":"34","author":[{"given":"Renaud","family":"Dumas","sequence":"first","affiliation":[{"name":"Laboratoire Mixte CNRS\/INRA\/Aventis, Aventis CropScience, 14-20 rue Pierre Baizet, 69263 Lyon, France, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France, and Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Biou","sequence":"additional","affiliation":[{"name":"Laboratoire Mixte CNRS\/INRA\/Aventis, Aventis CropScience, 14-20 rue Pierre Baizet, 69263 Lyon, France, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France, and Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Halgand","sequence":"additional","affiliation":[{"name":"Laboratoire Mixte CNRS\/INRA\/Aventis, Aventis CropScience, 14-20 rue Pierre Baizet, 69263 Lyon, France, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France, and Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Douce","sequence":"additional","affiliation":[{"name":"Laboratoire Mixte CNRS\/INRA\/Aventis, Aventis CropScience, 14-20 rue Pierre Baizet, 69263 Lyon, France, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France, and Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Duggleby","sequence":"additional","affiliation":[{"name":"Laboratoire Mixte CNRS\/INRA\/Aventis, Aventis CropScience, 14-20 rue Pierre Baizet, 69263 Lyon, France, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France, and Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2001,4,7]]},"reference":[{"key":"ar000082wb00001\/ar000082wb00001_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1021\/bi00428a012","volume":"28","author":"Chunduru S. K.","year":"1989","journal-title":"Biochemistry"},{"key":"ar000082wb00002\/ar000082wb00002_1","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1021\/bi00018a004","volume":"34","author":"Dumas R.","year":"1995","journal-title":"Biochemistry"},{"key":"ar000082wb00003\/ar000082wb00003_1","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/emboj\/16.12.3405","volume":"16","author":"Biou V.","year":"1997","journal-title":"EMBO J."},{"key":"ar000082wb00004\/ar000082wb00004_1","first-page":"2450","volume":"261","author":"Wek R. C.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ar000082wb00005\/ar000082wb00005_1","first-page":"663","volume":"203","author":"Wek R. C.","year":"1988","journal-title":"J. Mol. Biol."},{"key":"ar000082wb00006\/ar000082wb00006_1","first-page":"9651","volume":"14","author":"Petersen J. G. L.","year":"1986","journal-title":"Nucleic Acids Res."},{"key":"ar000082wb00007\/ar000082wb00007_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1042\/bj2620971","volume":"262","author":"Dumas R.","year":"1989","journal-title":"Biochem. J."},{"key":"ar000082wb00008\/ar000082wb00008_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/bj2770469","volume":"277","author":"Dumas R.","year":"1991","journal-title":"Biochem. J."},{"key":"ar000082wb00009\/ar000082wb00009_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1042\/bj2940821","volume":"294","author":"Dumas R.","year":"1993","journal-title":"Biochem. J."},{"key":"ar000082wb00010\/ar000082wb00010_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/BF00014556","volume":"21","author":"Curien G.","year":"1993","journal-title":"Plant Mol. Biol."},{"key":"ar000082wb00011\/ar000082wb00011_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1365-2958.1998.01130.x","volume":"30","author":"Akhmanova A.","year":"1998","journal-title":"Mol. Microbiol."},{"key":"ar000082wb00012\/ar000082wb00012_1","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1002\/j.1460-2075.1995.tb07330.x","volume":"14","author":"Zelenaya-Troitskaya O.","year":"1995","journal-title":"EMBO J."},{"key":"ar000082wb00013\/ar000082wb00013_1","first-page":"180","volume":"16","author":"Piatigorsky J.","year":"2000","journal-title":"J. Ocul. Pharm. Therapeut."},{"key":"ar000082wb00014\/ar000082wb00014_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/fgbi.1998.1106","volume":"26","author":"Thompson-Coffe C.","year":"1999","journal-title":"Fungal Genet. Biol."},{"key":"ar000082wb00015\/ar000082wb00015_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0167-4838(99)00119-3","volume":"1432","author":"Sirover M. A","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ar000082wb00016\/ar000082wb00016_1","first-page":"352","volume":"351","author":"Armstrong F. B.","year":"1974","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"ar000082wb00017\/ar000082wb00017_1","first-page":"1201","volume":"1197","author":"Armstrong F. B.","year":"1983","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ar000082wb00018\/ar000082wb00018_1","first-page":"189","volume":"8","author":"Hill R. K.","year":"1979","journal-title":"Bioorg. Chem."},{"key":"ar000082wb00019\/ar000082wb00019_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1042\/bj2880865","volume":"288","author":"Dumas R.","year":"1992","journal-title":"Biochem. J."},{"key":"ar000082wb00020\/ar000082wb00020_1","first-page":"1127","volume":"244","author":"Arfin S. M.","year":"1969","journal-title":"J. Biol. Chem."},{"key":"ar000082wb00021\/ar000082wb00021_1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.123.3202.848.a","volume":"123","author":"Umbarger H. E","year":"1956","journal-title":"Science"},{"key":"ar000082wb00022\/ar000082wb00022_1","first-page":"340","volume-title":"Photosynthesis:\u2009 from light to biosphere","author":"Biou V.","year":"1995"},{"key":"ar000082wb00023\/ar000082wb00023_1","first-page":"89","volume":"338","author":"Rane M. J.","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"ar000082wb00024\/ar000082wb00024_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1021\/bi00327a012","volume":"24","author":"Wierenga R. K.","year":"1985","journal-title":"Biochemistry"},{"key":"ar000082wb00025\/ar000082wb00025_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1107\/S0907444900001694","volume":"56","author":"Thomazeau K.","year":"2000","journal-title":"Acta Crystallogr. D"},{"key":"ar000082wb00026\/ar000082wb00026_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0014-5793(97)00410-9","volume":"408","author":"Dumas R.","year":"1997","journal-title":"FEBS Lett."},{"key":"ar000082wb00027\/ar000082wb00027_1","doi-asserted-by":"crossref","first-page":"12760","DOI":"10.1021\/bi980411g","volume":"37","author":"Wessel P. M.","year":"1998","journal-title":"Biochemistry"},{"key":"ar000082wb00028\/ar000082wb00028_1","first-page":"423","volume":"27","author":"Donadini R.","year":"2000","journal-title":"Aust. J. Plant Physiol."},{"key":"ar000082wb00029\/ar000082wb00029_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/jb.153.1.259-269.1983","volume":"153","author":"Primerano D. A.","year":"1983","journal-title":"J. Bacteriol."},{"key":"ar000082wb00030\/ar000082wb00030_1","first-page":"61","volume":"15","author":"Hill C. M.","year":"1999","journal-title":"Protein Expression Purif."},{"key":"ar000082wb00031\/ar000082wb00031_1","doi-asserted-by":"crossref","first-page":"12084","DOI":"10.1016\/S0021-9258(18)37895-5","volume":"263","author":"Shimizu S.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ar000082wb00032\/ar000082wb00032_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1438-8677.1994.tb00786.x","volume":"107","author":"Julliard J. H","year":"1994","journal-title":"Bot. Acta"},{"key":"ar000082wb00033\/ar000082wb00033_1","first-page":"131","volume":"158","author":"Shematek E. M.","year":"1973","journal-title":"Arch. Biochem. Biophys."},{"key":"ar000082wb00034\/ar000082wb00034_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0014-5793(88)80515-5","volume":"238","author":"Schulz A.","year":"1988","journal-title":"FEBS Lett."},{"key":"ar000082wb00035\/ar000082wb00035_1","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1021\/bi00463a027","volume":"29","author":"Aulabaugh A.","year":"1990","journal-title":"Biochemistry"},{"key":"ar000082wb00036\/ar000082wb00036_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1042\/bj3010813","volume":"301","author":"Dumas R.","year":"1994","journal-title":"Biochem. J."},{"key":"ar000082wb00037\/ar000082wb00037_1","unstructured":"Dumas, R.; Vives, F.; Job, D.; Douce, R.; Biou, V.; Pebay-Peyroula, E.; Cohen-Addad, C. Inhibition of acetohydroxy acid isomeroreductase by reaction intermediate analogues:\u2009 herbicidal effect, kinetic analysis and 3-D structural studies.Brighton Crop Protection ConferenceWeeds 1995; British Crop Protection Council:\u2009 Farnham, UK, 1995; Vol. 7B-3, pp 833\u2212842."},{"key":"ar000082wb00038\/ar000082wb00038_1","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1021\/bi9721389","volume":"37","author":"Halgand F.","year":"1998","journal-title":"Biochemistry"},{"key":"ar000082wb00039\/ar000082wb00039_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/bioinformatics\/15.4.305","volume":"15","author":"Gouet P.","year":"1999","journal-title":"Bioinformatics"},{"key":"ar000082wb00040\/ar000082wb00040_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0076-6879(96)66009-1","volume":"266","author":"Henikoff J. G.","year":"1996","journal-title":"Methods Enzymol."},{"key":"ar000082wb00041\/ar000082wb00041_1","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/bip.360221211","volume":"22","author":"Kabsch W.","year":"1983","journal-title":"Biopolymers"},{"key":"ar000082wb00042\/ar000082wb00042_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1006\/jmbi.1994.1602","volume":"242","author":"Dumas R.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ar000082wb00043\/ar000082wb00043_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/35022623","volume":"406","author":"Taylor W. R","year":"2000","journal-title":"Nature"},{"key":"ar000082wb00044\/ar000082wb00044_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1104\/pp.103.3.903","volume":"103","author":"Durner J.","year":"1993","journal-title":"Plant Physiol."},{"key":"ar000082wb00045\/ar000082wb00045_1","first-page":"359","volume":"256","author":"Lapr\u00e9vote O.","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ar000082wb00046\/ar000082wb00046_1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0021-9258(19)41867-X","volume":"250","author":"Hofler J. G.","year":"1975","journal-title":"J. Biol. Chem."},{"key":"ar000082wb00047\/ar000082wb00047_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0969-2126(00)00135-0","volume":"8","author":"Suresh S.","year":"2000","journal-title":"Structure Fold. Des."},{"key":"ar000082wb00048\/ar000082wb00048_1","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1021\/bi00184a016","volume":"33","author":"Lavie A.","year":"1994","journal-title":"Biochemistry"},{"key":"ar000082wb00049\/ar000082wb00049_1","first-page":"9884","volume":"95","author":"Takahashi S.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ar000082wb00050\/ar000082wb00050_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1021\/ol990839n","volume":"1","author":"Proteau P. J.","year":"1999","journal-title":"Org. Lett."},{"key":"ar000082wb00051\/ar000082wb00051_1","first-page":"2566","volume":"118","author":"Rohmer M.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ar000082wb00052\/ar000082wb00052_1","first-page":"36","volume":"33","author":"Duggleby R. G.","year":"2000","journal-title":"J. Biochem. Mol. Biol."},{"key":"ar000082wb00053\/ar000082wb00053_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0969-2126(93)90025-C","volume":"1","author":"Muller Y. A.","year":"1993","journal-title":"Structure"},{"key":"ar000082wb00054\/ar000082wb00054_1","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1021\/bi982412e","volume":"38","author":"Halgand F.","year":"1999","journal-title":"Biochemistry"},{"key":"ar000082wb00055\/ar000082wb00055_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1146\/annurev.bi.37.070168.002043","volume":"37","author":"Koshland D. E.","year":"1968","journal-title":"Annu. Rev. Biochem."},{"key":"ar000082wb00056\/ar000082wb00056_1","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1021\/ja000414s","volume":"122","author":"Proust-De Martin F.","year":"2000","journal-title":"J. Am. Chem. Soc."}],"container-title":["Accounts of Chemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ar000082w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T20:32:37Z","timestamp":1678912357000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ar000082w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,7]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5,1]]}},"alternative-id":["10.1021\/ar000082w"],"URL":"https:\/\/doi.org\/10.1021\/ar000082w","relation":{},"ISSN":["0001-4842","1520-4898"],"issn-type":[{"value":"0001-4842","type":"print"},{"value":"1520-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,7]]}}}