{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:12:00Z","timestamp":1792177920049,"version":"4.4.0"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acc. Chem. Res."],"published-print":{"date-parts":[[2008,10,21]]},"DOI":"10.1021\/ar700263g","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T05:22:02Z","timestamp":1214457722000},"page":"1366-1375","source":"Crossref","is-referenced-by-count":703,"title":["\u03b2-Peptidic Peptidomimetics"],"prefix":"10.1021","volume":"41","author":[{"given":"Dieter","family":"Seebach","sequence":"first","affiliation":[{"name":"Laboratorium f\u00fcr Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH Z\u00fcrich, Wolfgang-Pauli-Strasse 10, CH-8093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Laboratorium f\u00fcr Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH Z\u00fcrich, Wolfgang-Pauli-Strasse 10, CH-8093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,6,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/hlca.19960790402","volume":"79","author":"Seebach D.","year":"1996","journal-title":"Helv. Chim. Acta"},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/cbdv.200490087","volume":"1","author":"Seebach D.","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"ref2\/cit2b","first-page":"1","author":"Seebach D.","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"ref3\/cit3","first-page":"2256","volume":"2193","author":"Kirmse W.","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1002\/hlca.200490280","volume":"87","author":"Lelais G.","year":"2004","journal-title":"Helv. Chim. Acta"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/hlca.200790171","volume":"90","author":"Fl\u00f6gel O.","year":"2007","journal-title":"Helv. Chim. Acta"},{"key":"ref6\/cit6","unstructured":"We thank Fluka AG for discounted prices."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/hlca.19980810513","volume":"81","author":"Seebach D.","year":"1998","journal-title":"Helv. Chim. Acta"},{"issue":"12","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.tetasy.2006.05.008","volume":"17","author":"Davies S. G.","year":"2006","journal-title":"Tetrahedron: Asymmetry"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/hlca.200390149","volume":"86","author":"Seebach D.","year":"2003","journal-title":"Helv. Chim. Acta"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/bip.20088","volume":"76","author":"Lelais G.","year":"2004","journal-title":"Biopolymers"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1016\/j.tet.2004.06.043","volume":"60","author":"Seebach D.","year":"2004","journal-title":"Tetrahedron"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/1522-2675(200209)85:9<2577::AID-HLCA2577>3.0.CO;2-D","volume":"85","author":"Rueping M.","year":"2002","journal-title":"Helv. Chim. Acta"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1595::AID-ANIE1595>3.0.CO;2-0","volume":"38","author":"Seebach D.","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/hlca.339","volume":"89","author":"Lelais G.","year":"2006","journal-title":"Helv. Chim. Acta"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1002\/1522-2675(200209)85:9<2877::AID-HLCA2877>3.0.CO;2-W","volume":"85","author":"Seebach D.","year":"2002","journal-title":"Helv. Chim. Acta"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"13071","DOI":"10.1021\/ja963290l","volume":"118","author":"Appella D. H.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1021\/cr000045i","volume":"101","author":"Cheng R. P.","year":"2001","journal-title":"Chem. Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/cbdv.200590132","volume":"2","author":"Disney M. D.","year":"2005","journal-title":"Chem. Biodiversity"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/cbdv.200790121","volume":"4","author":"Weiss H. M.","year":"2007","journal-title":"Chem. Biodiversity"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/cbdv.200490102","volume":"1","author":"Lind R.","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/cbdv.200690136","volume":"3","author":"Heck T.","year":"2006","journal-title":"Chem. Biodiversity"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cbdv.200490014","volume":"1","author":"Seebach D.","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cbdv.200590020","volume":"2","author":"Arvidsson P. I.","year":"2005","journal-title":"Chem. Biodiversity"},{"key":"ref24\/cit24","unstructured":"Baruj Benacerruf, Jean Dausset, and George C. Snell received the 1980 Nobel Prize in Physiology or Medicine for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions,www.nobelprize.org."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/anie.199719381","volume":"36","author":"Zinkernagel R. M.","year":"1997","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev.bi.64.070195.002335","volume":"64","author":"Heemels M. T.","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1021\/jm981123l","volume":"42","author":"Poenaru S.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","unstructured":"Seebach, J. D. et al., hitherto unpublished results, Dept. of Internal Medicine, Laboratory for Transplantation Immunology, University Hospital, Z\u00fcrich, Switzerland."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/(SICI)1522-2675(19991006)82:10<1774::AID-HLCA1774>3.0.CO;2-O","volume":"82","author":"Werder M.","year":"1999","journal-title":"Helv. Chim. Acta"},{"key":"ref30\/cit30","unstructured":"David, R.; G\u00fcnther, R.; L\u00fchmann, T.; Seebach, D.; Hofmann, H.J.; BeckSickinger, A. G.Artificial Chemokines - Combining Chemistry and Molecular Biology for the Elucidation of Function of Interleukin-8, hitherto unpublished results, Institute for Biochemistry, University Leipzig, Germany."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/hlca.200590151","volume":"88","author":"Seebach D.","year":"2005","journal-title":"Helv. Chim. Acta"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"9468","DOI":"10.1021\/ja031625a","volume":"126","author":"Kritzer J.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1021\/ja042933r","volume":"127","author":"Kritzer J. A.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"13126","DOI":"10.1021\/ja053444+","volume":"127","author":"Stephens O.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bmc.2004.09.009","volume":"13","author":"Kritzer J. S.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/anie.200390205","volume":"42","author":"Seebach D.","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1021\/ja003689g","volume":"123","author":"Daura X.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/(SICI)1521-3773(19990503)38:9<1223::AID-ANIE1223>3.0.CO;2-A","volume":"38","author":"Gademann K.","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/(SICI)1522-2675(20000119)83:1<16::AID-HLCA16>3.0.CO;2-3","volume":"83","author":"Gademann K.","year":"2000","journal-title":"Helv. Chim. Acta"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00210-002-0673-4","volume":"367","author":"Nunn C.","year":"2003","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref41\/cit41","unstructured":"Seebach, D.; Dubost, E.; Mathad, R. I.; Jaun, B.; Limbach, M.; L\u00f6weneck, M.; Fl\u00f6gel, O.; Gardiner, J.; Capone, S.; Beck, A. K.; Hoyer, D.; Langenegger, D.; Widmer, H.,hitherto unpublished results, ETH Z\u00fcrich and Novartis Pharma AG, Basel."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/cbdv.200490136","volume":"1","author":"Wiegand H.","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/bdd.334","volume":"23","author":"Wiegand H.","year":"2002","journal-title":"Biopharm. Drug Dispos."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/cr040689g","volume":"105","author":"Tyndall J. D. A.","year":"2005","journal-title":"Chem. Rev."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/(SICI)1522-2675(19990609)82:6<957::AID-HLCA957>3.0.CO;2-H","volume":"82","author":"Gademann K.","year":"1999","journal-title":"Helv. Chim. Acta"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/1522-2675(20011017)84:10<2924::AID-HLCA2924>3.0.CO;2-E","volume":"84","author":"Gademann K.","year":"2001","journal-title":"Helv. Chim. Acta"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"13480","DOI":"10.1021\/ja073169m","volume":"129","author":"Trouche N.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nchembio746","volume":"1","author":"Fournel S.","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jlb.67.1.2","volume":"67","author":"van Kooten C.","year":"2000","journal-title":"J. Leukocyte Biol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.4049\/jimmunol.178.11.6700","volume":"178","author":"Habib M.","year":"2007","journal-title":"J. Immunol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1002\/hlca.200690277","volume":"89","author":"Namoto K.","year":"2006","journal-title":"Helv. Chim. Acta"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1021\/ol034977v","volume":"5","author":"Gelman M. A.","year":"2003","journal-title":"Org. Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/cbic.200400394","volume":"6","author":"Geueke B.","year":"2005","journal-title":"ChemBioChem"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1021\/ja017283v","volume":"124","author":"Umezawa N.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1021\/bi060285d","volume":"45","author":"Hitz T.","year":"2006","journal-title":"Biochemistry"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.bbamem.2007.07.011","volume":"1768","author":"Shimanouchi T.","year":"2007","journal-title":"Biochim. Biophys. Acta: Biomembr."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","DOI":"10.1201\/9781420040777","volume-title":"Cell-Penetrating Peptides: Processes and Applications","author":"Langel U.","year":"2002"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nbt1135","volume":"23","author":"Lonberg N.","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/11717","volume":"17","author":"Chapman A. P.","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1517\/13543784.15.1.13","volume":"15","author":"Reddy S. T.","year":"2006","journal-title":"Expert Opin. Invest. Drugs"}],"container-title":["Accounts of Chemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ar700263g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T21:45:07Z","timestamp":1679521507000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ar700263g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,26]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10,21]]}},"alternative-id":["10.1021\/ar700263g"],"URL":"https:\/\/doi.org\/10.1021\/ar700263g","relation":{},"ISSN":["0001-4842","1520-4898"],"issn-type":[{"value":"0001-4842","type":"print"},{"value":"1520-4898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,26]]}}}