{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:42:35Z","timestamp":1789627355261,"version":"build-2803163510"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2000,11,1]]},"DOI":"10.1021\/bc000008y","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:51:32Z","timestamp":1027648292000},"page":"762-771","source":"Crossref","is-referenced-by-count":128,"title":["Novel Tat-Peptide Chelates for Direct Transduction of Technetium-99m and Rhenium into Human Cells for Imaging and Radiotherapy"],"prefix":"10.1021","volume":"11","author":[{"given":"Valery","family":"Polyakov","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Dahlheimer","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Pica","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Luker","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Piwnica-Worms","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Radiopharmacology, Department of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2000,9,21]]},"reference":[{"key":"bc000008yb00001\/bc000008yb00001_1","volume-title":"Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals:\u2009 recent developments and encouraging results. Nucl. Med. Biol. 24, 485\u2212498","author":"Hom R.","year":"1997"},{"key":"bc000008yb00002\/bc000008yb00002_1","volume":"99","author":"Liu S.","year":"1999","journal-title":"Chem. Rev."},{"key":"bc000008yb00003\/bc000008yb00003_1","doi-asserted-by":"crossref","DOI":"10.1021\/cr980435t","volume":"99","author":"Jurisson S.","year":"1999","journal-title":"Chem. Rev."},{"key":"bc000008yb00004\/bc000008yb00004_1","doi-asserted-by":"crossref","DOI":"10.1021\/cr980451q","volume":"99","author":"Anderson C.","year":"1999","journal-title":"Chem. Rev."},{"key":"bc000008yb00005\/bc000008yb00005_1","doi-asserted-by":"crossref","DOI":"10.1007\/BF00181765","volume":"20","author":"Krenning E.","year":"1993","journal-title":"Eur. J. Nucl. Med."},{"key":"bc000008yb00006\/bc000008yb00006_1","volume":"39","author":"Pearson D.","year":"1996","journal-title":"J. Med. Chem."},{"key":"bc000008yb00007\/bc000008yb00007_1","volume":"38","author":"Lister-James J.","year":"1997","journal-title":"J. Nucl. Med."},{"key":"bc000008yb00008\/bc000008yb00008_1","volume-title":"Metal compounds in therapy and diagnosis. Science 261, 725\u2212730","author":"Abrams M.","year":"1993"},{"key":"bc000008yb00009\/bc000008yb00009_1","volume-title":"Engl. 33, 2258\u22122267.","author":"Schwochau K.","year":"1994"},{"key":"bc000008yb00010\/bc000008yb00010_1","doi-asserted-by":"crossref","DOI":"10.1021\/cr9804386","volume":"99","author":"Volkert W.","year":"1999","journal-title":"Chem. Rev."},{"key":"bc000008yb00011\/bc000008yb00011_1","volume":"49","author":"Flewelling R.","year":"1986","journal-title":"Biophys J."},{"key":"bc000008yb00012\/bc000008yb00012_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.30.18188","volume":"271","author":"Derossi D.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bc000008yb00013\/bc000008yb00013_1","volume-title":"Proc Natl Acad Sci U.S.A. 95","author":"Avrameas A.","year":"1998"},{"key":"bc000008yb00014\/bc000008yb00014_1","volume-title":"Intercellular trafficking and protein delivery by a Herpesvirus structural protein. Cell 88, 223\u2212233","author":"Elliot G.","year":"1997"},{"key":"bc000008yb00015\/bc000008yb00015_1","volume-title":"Functional similarity of HIV-1 rev and HTLV-1 rex proteins:\u2009 identification of a new nucleolar-targeting signal in rev protein. Biochem. Biophys. Res. Commun. 162, 963\u2212970","author":"Kubota S.","year":"1989"},{"key":"bc000008yb00016\/bc000008yb00016_1","volume-title":"Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55, 1189\u22121193","author":"Frankel A.","year":"1988"},{"key":"bc000008yb00017\/bc000008yb00017_1","volume-title":"Proc Natl Acad Sci U.S.A. 91","author":"Fawell S.","year":"1994"},{"key":"bc000008yb00018\/bc000008yb00018_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0962-8924(98)80017-2","volume":"8","author":"Derossi D.","year":"1998","journal-title":"Trends Cell Biol."},{"key":"bc000008yb00019\/bc000008yb00019_1","volume-title":"Transduction of full-length TAT fusion proteins directly into mammalian cells:\u2009 TAT-p27Kip1 induces cell migration. Nat. Med. 4, 1449\u22121452","author":"Nagahara H.","year":"1998"},{"key":"bc000008yb00020\/bc000008yb00020_1","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1097-4547(19961015)46:2<258::AID-JNR14>3.0.CO;2-Z","volume":"46","author":"Schluesener H.","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"bc000008yb00021\/bc000008yb00021_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.25.16010","volume":"272","author":"Vives E.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bc000008yb00022\/bc000008yb00022_1","volume-title":"High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate Chem. 10, 186\u2212191","author":"Josephson L.","year":"1999"},{"key":"bc000008yb00023\/bc000008yb00023_1","volume-title":"Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res. 53, 977\u2212984","author":"Piwnica-Worms D.","year":"1993"},{"key":"bc000008yb00024\/bc000008yb00024_1","volume-title":"Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somatic Cell. Mol. Genet. 11, 117\u2212126","author":"Akiyama S. I.","year":"1985"},{"key":"bc000008yb00025\/bc000008yb00025_1","volume-title":"Mitotic and G2 checkpoint control:\u2009 regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501\u22121505","author":"Peng C.-Y.","year":"1997"},{"key":"bc000008yb00026\/bc000008yb00026_1","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.81.5.731","volume":"81","author":"Piwnica-Worms D.","year":"1983","journal-title":"J. Gen. Physiol."},{"key":"bc000008yb00027\/bc000008yb00027_1","volume-title":"Characterization of functional assays of P-glycoprotein transport activity. Leukemia 11, 1131\u22121137","author":"Bosch I.","year":"1997"},{"key":"bc000008yb00028\/bc000008yb00028_1","volume":"16","author":"Lamson M.","year":"1975","journal-title":"J. Nucl. Med."},{"key":"bc000008yb00029\/bc000008yb00029_1","volume-title":"Circulation 82","author":"Piwnica-Worms D.","year":"1990"},{"key":"bc000008yb00030\/bc000008yb00030_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 96","author":"Rao V.","year":"1999"},{"key":"bc000008yb00031\/bc000008yb00031_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00015a018","volume":"38","author":"Herman L. W.","year":"1995","journal-title":"J. Med. Chem."},{"key":"bc000008yb00032\/bc000008yb00032_1","volume-title":"Novel gallium(III) complexes transported by MDR1 P-glycoprotein:\u2009 potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo. Chem. Biol. 7, 335\u2212343","author":"Sharma V.","year":"2000"},{"key":"bc000008yb00033\/bc000008yb00033_1","volume-title":"Rhenium(V) and technetium(V) oxo complexes of an N2N\u2018S peptidic chelator:\u2009 evidence of interconversion between the syn and anti conformations. Inorg. Chem. 36, 5799\u22125808","author":"Wong E.","year":"1997"},{"key":"bc000008yb00034\/bc000008yb00034_1","volume-title":"Tc-99m-labeling, and in vitro characterization of HYNIC and N3S modified RC-160 and [Tyr3]octreotide. Bioconjugate Chem. 10, 431\u2212438.","author":"Decristoforo C.","year":"1999"},{"key":"bc000008yb00035\/bc000008yb00035_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/jm960532j","volume":"40","author":"Meegalla S.","year":"1997","journal-title":"J. Med. Chem."},{"key":"bc000008yb00036\/bc000008yb00036_1","volume-title":"Characterization of multidrug-resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry 34, 12210\u221212220","author":"Piwnica-Worms D.","year":"1995"},{"key":"bc000008yb00037\/bc000008yb00037_1","volume":"39","author":"Sharma V.","year":"1996","journal-title":"J. Med. Chem."},{"key":"bc000008yb00038\/bc000008yb00038_1","doi-asserted-by":"crossref","DOI":"10.1021\/cr980429x","volume":"99","author":"Sharma V.","year":"1999","journal-title":"Chem. Rev."},{"key":"bc000008yb00039\/bc000008yb00039_1","volume":"31","author":"Ambudkar S.","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"bc000008yb00040\/bc000008yb00040_1","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/j.1460-2075.1991.tb07697.x","volume":"10","author":"Mann D.","year":"1991","journal-title":"EMBO"},{"key":"bc000008yb00041\/bc000008yb00041_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.bi.63.070194.003441","volume":"63","author":"Jones K.","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"bc000008yb00042\/bc000008yb00042_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 95","author":"Hobbs S.","year":"1998"},{"key":"bc000008yb00043\/bc000008yb00043_1","volume":"41","author":"Lister-James J.","year":"1997","journal-title":"Q. J. Nucl. Med."},{"key":"bc000008yb00044\/bc000008yb00044_1","volume-title":"Can a cysteine challenge assay predict the in vivo behavior of Tc-99m-labeled antibodies? Nucl. Med. Biol. 21, 1035\u22121044","author":"Hnatowich D.","year":"1994"},{"key":"bc000008yb00045\/bc000008yb00045_1","doi-asserted-by":"crossref","unstructured":"Waibel, R., Alberto, R., Willuda, J., Finnern, R., Schibli, R., Stichelberger, A., Egli, A., Abram, U., Mach, J.P., and Pluckthun, A., et al. (1999) Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex.\n                      Nat. Biotechnol.\n                      17\n                      , 897\u2212901.","DOI":"10.1038\/12890"},{"key":"bc000008yb00046\/bc000008yb00046_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 96","author":"Wolf G.","year":"1999"},{"key":"bc000008yb00047\/bc000008yb00047_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.3.1623","volume":"273","author":"Efthymiadis A.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bc000008yb00048\/bc000008yb00048_1","volume-title":"Microautoradiographic analysis of the normal organ distribution of radioiodinated single-chain Fv and other immunoglobulin forms. Cancer Res. 53, 3776\u22123783","author":"Yokota T.","year":"1993"},{"key":"bc000008yb00049\/bc000008yb00049_1","unstructured":"Choi, C., Lang, L., Lee, J., Webber, K., Yoo, T., Chang, H., Le, N., Jagoda, E., Paik, C., and Pastan, I., et al. (1995) Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.\n                      Cancer Res\n                      .\n                      55\n                      , 5323\u22125329."},{"key":"bc000008yb00050\/bc000008yb00050_1","volume":"36","author":"Behr T.","year":"1995","journal-title":"J. Nucl. Med."},{"key":"bc000008yb00051\/bc000008yb00051_1","volume-title":"Chemical design of radiolabeled antibody fragments for low renal radioactivity levels. Cancer Res. 59, 128\u2212134","author":"Arano Y.","year":"1999"},{"key":"bc000008yb00052\/bc000008yb00052_1","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.1988.68.3.911","volume":"68","author":"Silbernagl S.","year":"1988","journal-title":"Physiol. Rev."},{"key":"bc000008yb00053\/bc000008yb00053_1","volume":"34","author":"Duncan J.","year":"1993","journal-title":"J. Nucl. Med."},{"key":"bc000008yb00054\/bc000008yb00054_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 94","author":"Harada K.","year":"1997"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc000008y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T06:57:04Z","timestamp":1678777024000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc000008y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,21]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,11,1]]}},"alternative-id":["10.1021\/bc000008y"],"URL":"https:\/\/doi.org\/10.1021\/bc000008y","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,21]]}}}