{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:06:30Z","timestamp":1792130790464,"version":"4.4.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1021\/bc034044j","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T05:27:16Z","timestamp":1074662836000},"page":"162-167","source":"Crossref","is-referenced-by-count":139,"title":["Dendritic Polyglycerol Sulfates as New Heparin Analogues and Potent Inhibitors of the Complement System"],"prefix":"10.1021","volume":"15","author":[{"given":"Holger","family":"T\u00fcrk","sequence":"first","affiliation":[{"name":"Freiburg Materials Research Center, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Strasse 21, 79104 Freiburg, Germany, and Pharmaceutical Institute, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[{"name":"Freiburg Materials Research Center, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Strasse 21, 79104 Freiburg, Germany, and Pharmaceutical Institute, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Alban","sequence":"additional","affiliation":[{"name":"Freiburg Materials Research Center, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Strasse 21, 79104 Freiburg, Germany, and Pharmaceutical Institute, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,12,6]]},"reference":[{"key":"bc034044jb00001\/bc034044jb00001_1","doi-asserted-by":"crossref","first-page":"64S","DOI":"10.1378\/chest.119.1_suppl.64S","volume":"119","author":"Hirsh J.","year":"2001","journal-title":"Chest"},{"key":"bc034044jb00002\/bc034044jb00002_1","first-page":"52","volume":"7","author":"Demir M.","year":"2001","journal-title":"Clin. Appl. Thromb. Hemostasis"},{"key":"bc034044jb00003\/bc034044jb00003_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00168a017","volume":"33","author":"Linhardt R. J.","year":"1990","journal-title":"J. Med. Chem."},{"key":"bc034044jb00004\/bc034044jb00004_1","volume-title":"Heparin-Protein-Wechselwirkungen. Angew. Chem. 114, 426\u2212450","author":"Capila I.","year":"2002"},{"key":"bc034044jb00005\/bc034044jb00005_1","volume-title":"The Synthetic Pentasaccharide Fondaparinux:\u2009 First in the Class of Antithrombotic Agents that Selectively Inhibit Coagulation Factor Xa. Semin. Thromb. Hemostasis 28, 393\u2212402","author":"Petitou M.","year":"2002"},{"key":"bc034044jb00006\/bc034044jb00006_1","volume-title":"Ximelagatran. Curr. Opin. Investig. Drugs 3, 246\u2212251","author":"Hopfner R.","year":"2002"},{"key":"bc034044jb00007\/bc034044jb00007_1","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.148.10.3210","volume":"148","author":"Weiler J. M.","year":"1992","journal-title":"J. Immunol."},{"key":"bc034044jb00008\/bc034044jb00008_1","volume":"8","author":"Winkelhake J. L.","year":"1991","journal-title":"Glycoconjugate J."},{"key":"bc034044jb00009\/bc034044jb00009_1","volume":"121","author":"Arfors K.-E.","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"bc034044jb00010\/bc034044jb00010_1","volume-title":"Heparin oligosaccharides:\u2009 New analogues development and applications. Carbohydrates in Drug Design","author":"Linhardt R. J.","year":"1997"},{"key":"bc034044jb00011\/bc034044jb00011_1","first-page":"23","volume":"80","author":"Zacharski L. R.","year":"1998","journal-title":"Thromb. Haemostasis"},{"key":"bc034044jb00012\/bc034044jb00012_1","first-page":"8","volume":"17","author":"Engelberg H.","year":"1991","journal-title":"Semin. Thromb. Hemostasis"},{"key":"bc034044jb00013\/bc034044jb00013_1","doi-asserted-by":"crossref","first-page":"L779","DOI":"10.1152\/ajplung.2000.279.5.L779","volume":"279","author":"Garg H. G.","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"bc034044jb00014\/bc034044jb00014_1","volume":"260","author":"Ley K.","year":"1991","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"bc034044jb00015\/bc034044jb00015_1","volume-title":"Analysis, Biotechnology, Modification, Antiviral, Biomedical and other Application","author":"DeClercq E.","year":"1993"},{"key":"bc034044jb00016\/bc034044jb00016_1","volume-title":"Heparin-coated cardiopulmonary bypass circuits:\u2009 current status. Perfusion 16, 417\u2212428","author":"Hsu L. C.","year":"2001"},{"key":"bc034044jb00017\/bc034044jb00017_1","volume-title":"Partial synthetic glucan sulfates as potential new antithrombotics. Biomacromolecules 2, 354\u2212361","author":"Alban S.","year":"2001"},{"key":"bc034044jb00018\/bc034044jb00018_1","volume-title":"Heparinoids:\u2009 Structure, Biological Activities and Therapeutic Applications. Planta Med. 65, 301\u2212306","author":"Gunay N. S.","year":"1999"},{"key":"bc034044jb00019\/bc034044jb00019_1","volume-title":"Carbohydrates with anticoagulant and antithrombotic properties. Carbohydrates in Drug Design","author":"Alban S.","year":"1997"},{"key":"bc034044jb00020\/bc034044jb00020_1","volume-title":"Hyperbranched Polyether Polyols:\u2009 A Modular Approach to Complex Polymer Architectures. Adv. Mater. 12, 235\u2212239","author":"Sunder A.","year":"2000"},{"key":"bc034044jb00021\/bc034044jb00021_1","doi-asserted-by":"crossref","DOI":"10.1016\/S1389-0352(01)00063-0","volume":"90","author":"Frey H.","year":"2002","journal-title":"Rev. Mol. Biotech."},{"key":"bc034044jb00022\/bc034044jb00022_1","volume-title":"Controlled Synthesis of Hyperbranched Polyglycerols by Ring-Opening Multibranching Polymerization. Macromolecules 32, 4240\u22124246","author":"Sunder A.","year":"1999"},{"key":"bc034044jb00023\/bc034044jb00023_1","volume-title":"A conductometric method for the determination of sulphate and carboxyl groups in heparin and other mucopolysaccharides. Carbohydr. Res. 39, 168\u2212176","author":"Casu B.","year":"1975"},{"key":"bc034044jb00024\/bc034044jb00024_1","volume-title":"Synthesis of Laminarin Sulfates with Anticoagulant Activity. Arzneim.-Forsch.\/Drug Res. 42, 1005\u22121008","author":"Alban S.","year":"1992"},{"key":"bc034044jb00025\/bc034044jb00025_1","volume-title":"Minimalanforderungen zur Gewinnung von Citratplasma f\u00fcr h\u00e4mostaseologische Analysen. Laboratory Medicine 19, 143\u2212145","author":"Witt I.","year":"1995"},{"key":"bc034044jb00026\/bc034044jb00026_1","volume-title":"Differentiation between the complement modulating effects of an arabinogalactan-protein from Echinacea purpurea and of heparin. Planta Med. 68, 1118\u22121124","author":"Alban S.","year":"2002"},{"key":"bc034044jb00027\/bc034044jb00027_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja994363e","volume":"122","author":"Haag R.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"bc034044jb00028\/bc034044jb00028_1","volume-title":"Overview of the Preparation, Use and Biological Studies on Polyglycerol Polyricinoleate (PGPR). Food Chem. Toxicol. 36, 711\u2212718","author":"Wilson R.","year":"1998"},{"key":"bc034044jb00029\/bc034044jb00029_1","volume-title":"The Fate of Ingested Glyceran Esters of Condensed Castor Oil Fatty Acids [Polyglycerol Polyricinoleate (PGPR)] in Rat. Food Chem. Toxicol. 36, 719\u2212738","author":"Howes D.","year":"1998"},{"key":"bc034044jb00030\/bc034044jb00030_1","volume":"1","author":"Gait M. J.","year":"1974","journal-title":"J. Chem. Soc., Perkin Trans."},{"key":"bc034044jb00031\/bc034044jb00031_1","volume-title":"The molecular-mass dependence of dextran sulfate enhancement of inactivation of thrombin and fibrinogen and on factor Xa neutralization by antithrombin III. Biol. Chem. 370, 715\u2212721","author":"Oshima G.","year":"1989"},{"key":"bc034044jb00032\/bc034044jb00032_1","volume-title":"Anticoagulant activity of \u03b2-1,3-glucan sulfates in dependence on their molecular weight. Pure Appl. Chem. 66, 2403\u22122406","author":"Alban S.","year":"1994"},{"key":"bc034044jb00033\/bc034044jb00033_1","doi-asserted-by":"crossref","DOI":"10.1080\/09205063.1998.9753062","volume":"9","author":"Mauray S.","year":"1998","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"bc034044jb00034\/bc034044jb00034_1","volume-title":"Further data on the structure of brown seaweed fucans:\u2009 relationships with anticoagulant activity. Carbohydr. Res. 319, 154\u2212165","author":"Chevolot L.","year":"1999"},{"key":"bc034044jb00035\/bc034044jb00035_1","volume-title":"PCT Int. Appl. Patent WO 2002036132","author":"Yvin J.-C.","year":"2002"},{"key":"bc034044jb00036\/bc034044jb00036_1","doi-asserted-by":"crossref","unstructured":"Levi, M., ten Cate, H., and van der Poll, T. (2002) Endothelium:\u2009 interface between coagulation and inflammation.Crit. Care Med.30, S220\u2212S224.","DOI":"10.1097\/00003246-200205001-00008"},{"key":"bc034044jb00037\/bc034044jb00037_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0022-3999(01)00302-6","volume":"52","author":"Black P. H.","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"bc034044jn00001\/bc034044jn00001_1","volume-title":"alternative complement activation","author":"Abbreviations ACA"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc034044j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T19:25:27Z","timestamp":1682623527000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc034044j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,6]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"alternative-id":["10.1021\/bc034044j"],"URL":"https:\/\/doi.org\/10.1021\/bc034044j","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,6]]}}}