{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:53:23Z","timestamp":1790218403640,"version":"4.1.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2010,12,15]]},"DOI":"10.1021\/bc100204m","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T14:37:52Z","timestamp":1288708672000},"page":"2205-2212","source":"Crossref","is-referenced-by-count":117,"title":["Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy"],"prefix":"10.1021","volume":"21","author":[{"given":"Suzanne","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily F.","family":"Crownover","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Stayton","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle Washington 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,11,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.iy.12.040194.002005","volume":"12","author":"Boon T.","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.4049\/jimmunol.133.3.1664","volume":"133","author":"Engers H.","year":"1984","journal-title":"J. Immunol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/1521-4141(200208)32:8<2356::AID-IMMU2356>3.0.CO;2-Z","volume":"32","author":"Maurer T.","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/jbm.a.31019","volume":"81","author":"Hamdy S.","year":"2007","journal-title":"J. Biomed. Mater. Res."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/eji.200737169","volume":"37","author":"Heit A.","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0165-2478(00)00244-3","volume":"74","author":"Bonnet M. C.","year":"2000","journal-title":"Immunol. Lett."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.addr.2006.05.005","volume":"58","author":"Harrop R.","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0198-8859(97)00081-5","volume":"54","author":"Goletz T. J.","year":"1997","journal-title":"Hum. Immunol."},{"key":"ref9\/cit9","author":"Shaw C. A.","year":"2006","journal-title":"Infect. Immunol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ymeth.2006.05.027","volume":"40","author":"Altin J. G.","year":"2006","journal-title":"Methods"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1023\/A:1020151025412","volume":"22","author":"Chikh G.","year":"2002","journal-title":"Biosci. Rep."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.4049\/jimmunol.173.4.2578","volume":"173","author":"Haining W. N.","year":"2004","journal-title":"J. Immunol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.imbio.2006.05.021","volume":"211","author":"Tacken P. J.","year":"2006","journal-title":"Immunobiology"},{"key":"ref14\/cit14","first-page":"661","volume":"81","author":"Maloy K. J.","year":"1994","journal-title":"Immunology"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2567.2005.02268.x","volume":"117","author":"Shen H.","year":"2006","journal-title":"Immunology"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1096\/fj.02-0088com","volume":"16","author":"Panyam J.","year":"2002","journal-title":"FASEB J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/(SICI)1097-4636(20000615)50:4<591::AID-JBM15>3.0.CO;2-9","volume":"50","author":"Newman K. D.","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/nbt1332","volume":"25","author":"Reddy S. T.","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0022-1759(97)00102-6","volume":"206","author":"Partidos C. D.","year":"1997","journal-title":"J. Immunol. Methods"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/j.biomaterials.2004.08.023","volume":"26","author":"Bennewitz N. L.","year":"2005","journal-title":"Biomaterials"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jconrel.2007.09.013","volume":"125","author":"Mundargi R. C.","year":"2008","journal-title":"J. Controlled Release"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jbm.10019","volume":"60","author":"Newman K. D.","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.4049\/jimmunol.153.11.4925","volume":"153","author":"Harding C. V.","year":"1994","journal-title":"J. Immunol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1073\/pnas.90.11.4942","volume":"90","author":"Kovacsovics-Bankowski M.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1023\/A:1022271020390","volume":"20","author":"Thiele L.","year":"2003","journal-title":"Pharm. Res."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2007.11.153","volume":"366","author":"Yoshikawa T.","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.vaccine.2007.12.037","volume":"26","author":"Yoshikawa T.","year":"2008","journal-title":"Vaccine"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1073\/pnas.0930644100","volume":"100","author":"Murthy N.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jconrel.2005.02.027","volume":"105","author":"Kwon Y. J.","year":"2005","journal-title":"J. Controlled Release"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/bc049956f","volume":"15","author":"Standley S. M.","year":"2004","journal-title":"Bioconjugate Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/mp800068x","volume":"5","author":"Bachelder E. M.","year":"2008","journal-title":"Mol. Pharm."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-3659(99)00114-5","volume":"61","author":"Murthy N.","year":"1999","journal-title":"J. Controlled Release"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/1521-3900(200107)172:1<49::AID-MASY49>3.0.CO;2-Y","volume":"172","author":"Murthy N.","year":"2001","journal-title":"Macromol. Symp."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1021\/bc0100408","volume":"12","author":"Cheung C. Y.","year":"2001","journal-title":"Bioconjugate Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/bc010053l","volume":"13","author":"Lackey C. A.","year":"2002","journal-title":"Bioconjugate Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/bc020056d","volume":"14","author":"Murthy N.","year":"2003","journal-title":"Bioconjugate Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2003.06.001","volume":"93","author":"Bulmus V.","year":"2003","journal-title":"J. Controlled Release"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jconrel.2005.01.009","volume":"104","author":"El-Sayed M. E.","year":"2005","journal-title":"J. Controlled Release"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2008.10.004","volume":"133","author":"Convertine A. J.","year":"2009","journal-title":"J. Controlled Release"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/mp9002267","volume":"7","author":"Duvall C. L.","year":"2009","journal-title":"Mol. Pharm."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1021\/bc800317a","volume":"20","author":"Flanary S.","year":"2009","journal-title":"Bioconjugate Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.4049\/jimmunol.180.6.4000","volume":"180","author":"Wakabayashi A.","year":"2008","journal-title":"J. Immunol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00262-007-0346-8","volume":"57","author":"Llopiz D.","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.vaccine.2008.01.030","volume":"26","author":"Schlosser E.","year":"2008","journal-title":"Vaccine"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cellimm.2004.12.007","volume":"231","author":"Bohnenkamp H. R.","year":"2004","journal-title":"Cellular Immunol."},{"key":"ref46\/cit46","first-page":"39","volume":"34","author":"Eo S.-K.","year":"2004","journal-title":"J. Bacteriol. Virol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1078\/0171-2985-00190","volume":"2006","author":"Chung Y.","year":"2002","journal-title":"Immunobiology"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1083\/jcb.91.3.716","volume":"91","author":"Besterman J. M.","year":"1981","journal-title":"J. Cell Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0248-4900(98)80338-9","volume":"90","author":"Weaver D. J.","year":"1998","journal-title":"Biol. Cell"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1023\/A:1022219003551","volume":"20","author":"Panyam J.","year":"2003","journal-title":"Pharm. Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00262-005-0013-x","volume":"55","author":"Johnston D.","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","volume":"23","author":"Trombetta E. S.","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","volume":"20","author":"Guermonprez P.","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.7809629","volume":"267","author":"Kovacsovics-Bankowski M.","year":"1995","journal-title":"Science"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2567.2004.01920.x","volume":"112","author":"Brode S.","year":"2004","journal-title":"Immunology"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature01912","volume":"425","author":"Houde M.","year":"2003","journal-title":"Nature"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00262-006-0276-x","volume":"56","author":"De Jong S.","year":"2007","journal-title":"Cancer Immunol. Immunother."}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc100204m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T20:48:42Z","timestamp":1682196522000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc100204m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,2]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12,15]]}},"alternative-id":["10.1021\/bc100204m"],"URL":"https:\/\/doi.org\/10.1021\/bc100204m","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,2]]}}}