{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:29:43Z","timestamp":1760783383581},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2011,4,20]]},"DOI":"10.1021\/bc1005637","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T21:48:04Z","timestamp":1301348884000},"page":"540-545","source":"Crossref","is-referenced-by-count":15,"title":["Development of a Cell-Selective and Intrinsically Active Multikinase Inhibitor Bioconjugate"],"prefix":"10.1021","volume":"22","author":[{"given":"Stefan","family":"Harmsen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Emmy M.","family":"Dolman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Nemes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Kreatech Biotechnology BV, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"Szokol","sequence":"additional","affiliation":[{"name":"Vichem Chemie, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Pat\u00f3","sequence":"additional","affiliation":[{"name":"Vichem Chemie, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"K\u00e9ri","sequence":"additional","affiliation":[{"name":"Vichem Chemie, Budapest, Hungary"},{"name":"Pathobiochemistry Research Group of Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"\u0150rfi","sequence":"additional","affiliation":[{"name":"Vichem Chemie, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim E.","family":"Hennink","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robbert J.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/hep.21921","volume":"46","author":"Tugues S.","year":"2007","journal-title":"Hepatology"},{"key":"ref2\/cit2","first-page":"1061","volume":"122","author":"Huang M.","year":"2009","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref3\/cit3","first-page":"332","volume":"13","author":"Antoniu S. A.","year":"2010","journal-title":"IDrugs"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/138920009788897975","volume":"10","author":"Hartmann J. T.","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1093\/annonc\/mdm489","volume":"18","author":"Mego M.","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11912-007-0040-1","volume":"9","author":"George S.","year":"2007","journal-title":"Curr. Oncol. Rep."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.addr.2010.07.011","volume":"62","author":"Dolman M. E.","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1073\/pnas.0812413106","volume":"106","author":"Gajiwala K. S.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.276.5314.955","volume":"276","author":"Mohammadi M.","year":"1997","journal-title":"Science"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/jm0204183","volume":"46","author":"Sun L.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jconrel.2008.08.013","volume":"132","author":"Fretz M. M.","year":"2008","journal-title":"J. Controlled Release"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ab.2009.01.022","volume":"387","author":"Hilhorst R.","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1158\/0008-5472.CAN-07-6307","volume":"68","author":"Hilberg F.","year":"2008","journal-title":"Cancer Res."},{"key":"ref14\/cit14","first-page":"4152","volume":"60","author":"Laird A. D.","year":"2000","journal-title":"Cancer Res."},{"key":"ref15\/cit15","first-page":"327","volume":"9","author":"Mendel D. B.","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/jpet.106.106054","volume":"319","author":"Prakash J.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/hep.23421","volume":"51","author":"Moreno M.","year":"2010","journal-title":"Hepatology"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/ic062055t","volume":"46","author":"Williams D. S.","year":"2007","journal-title":"Inorg. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1021\/ol036283s","volume":"6","author":"Zhang L.","year":"2004","journal-title":"Org. Lett."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1002\/chem.200800294","volume":"14","author":"Maksimoska J.","year":"2008","journal-title":"Chemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1002\/anie.201000682","volume":"49","author":"Wilbuer A.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1039\/B816249B","volume":"14","author":"Spencer J.","year":"2009","journal-title":"Dalton Trans."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/jm100020w","volume":"54","author":"Gasser G.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2174\/092986710791859306","volume":"17","author":"Chavain N.","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/om100964h","volume":"30","author":"Hillard E. A.","year":"2011","journal-title":"Organometallics"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc1005637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T22:11:03Z","timestamp":1682460663000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc1005637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,31]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4,20]]}},"alternative-id":["10.1021\/bc1005637"],"URL":"https:\/\/doi.org\/10.1021\/bc1005637","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,31]]}}}