{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:04:07Z","timestamp":1772885047909,"version":"3.50.1"},"reference-count":94,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2012,3,21]]},"DOI":"10.1021\/bc2004999","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T22:57:02Z","timestamp":1323903422000},"page":"309-323","source":"Crossref","is-referenced-by-count":44,"title":["The Dock-and-Lock Method Combines Recombinant Engineering with Site-Specific Covalent Conjugation To Generate Multifunctional Structures"],"prefix":"10.1021","volume":"23","author":[{"given":"Edmund A.","family":"Rossi","sequence":"first","affiliation":[{"name":"IBC Pharmaceuticals, Inc.; \u2021Garden State Cancer Center, Center for Molecular Medicine and Immunology; and \u00a7Immunomedics, Inc.; each in Morris Plains, New Jersey, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"IBC Pharmaceuticals, Inc.; \u2021Garden State Cancer Center, Center for Molecular Medicine and Immunology; and \u00a7Immunomedics, Inc.; each in Morris Plains, New Jersey, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Hsing","family":"Chang","sequence":"additional","affiliation":[{"name":"IBC Pharmaceuticals, Inc.; \u2021Garden State Cancer Center, Center for Molecular Medicine and Immunology; and \u00a7Immunomedics, Inc.; each in Morris Plains, New Jersey, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nbt1127","volume":"23","author":"Binz H. K.","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.copbio.2005.06.005","volume":"16","author":"Binz H. K.","year":"2005","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tibtech.2010.03.007","volume":"28","author":"Cuesta A. M.","year":"2010","journal-title":"Trends Biotechnol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.tibtech.2005.07.007","volume":"23","author":"Hey T.","year":"2005","journal-title":"Trends Biotechnol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1110\/ps.051817606","volume":"15","author":"Hosse R. J.","year":"2006","journal-title":"Protein Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/protein\/11.6.495","volume":"11","author":"Lo K. M.","year":"1998","journal-title":"Protein Eng."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00262-002-0353-8","volume":"52","author":"Pastan I.","year":"2003","journal-title":"Cancer Immunol. Immunother."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.166.1.559","volume":"166","author":"Kishore U.","year":"2001","journal-title":"J. Immunol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.4049\/jimmunol.148.5.1547","volume":"148","author":"Kostelny S. A.","year":"1992","journal-title":"J. Immunol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/jmbi.1994.0062","volume":"246","author":"Pack P.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1073\/pnas.94.5.1663","volume":"94","author":"Terskikh A. V.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"14385","DOI":"10.1074\/jbc.M011669200","volume":"276","author":"Willuda J.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"e5381","DOI":"10.1371\/journal.pone.0005381","volume":"4","author":"Cuesta A. M.","year":"2009","journal-title":"PLoS One"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/bies.20805","volume":"30","author":"Deyev S. M.","year":"2008","journal-title":"Bioessays"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1096\/fj.08-111484","volume":"22","author":"Fan C. Y.","year":"2008","journal-title":"FASEB J."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/bi00121a001","volume":"31","author":"Pack P.","year":"1992","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1182\/blood-2003-04-1039","volume":"102","author":"Borsi L.","year":"2003","journal-title":"Blood"},{"key":"ref18\/cit18","first-page":"3202","volume":"63","author":"Halin C.","year":"2003","journal-title":"Cancer Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0022-3565(24)29633-6","volume":"297","author":"Pepinsky R. B.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1016\/j.bmcl.2004.09.083","volume":"14","author":"Tan L. P.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nmeth729","volume":"2","author":"Burbulis I.","year":"2005","journal-title":"Nat. Methods"},{"key":"ref22\/cit22","first-page":"195","volume":"356","author":"Los G. V.","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nbt765","volume":"21","author":"Keppler A.","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.281.5374.269","volume":"281","author":"Griffin B. A.","year":"1998","journal-title":"Science"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nmeth749","volume":"2","author":"Miller L. W.","year":"2005","journal-title":"Nat. Methods"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cyto.a.20649","volume":"75","author":"Robers M.","year":"2009","journal-title":"Cytometry A"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/la904829y","volume":"26","author":"Engin S.","year":"2010","journal-title":"Langmuir"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1021\/bc200079e","volume":"22","author":"Recker T.","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1021\/bc9800217","volume":"9","author":"Saviranta P.","year":"1998","journal-title":"Bioconjugate Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/abio.1998.2770","volume":"262","author":"Duffy S.","year":"1998","journal-title":"Anal. Biochem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1050-3862(99)00037-6","volume":"16","author":"Airenne K. J.","year":"1999","journal-title":"Biomol. Eng."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tibtech.2007.04.001","volume":"25","author":"Laitinen O. H.","year":"2007","journal-title":"Trends Biotechnol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1073\/pnas.0600982103","volume":"103","author":"Rossi E. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.289.5485.1760","volume":"289","author":"MacBeath G.","year":"2000","journal-title":"Science"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.072685299","volume":"99","author":"Hodneland C. D.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0005-2760(95)00145-3","volume":"1259","author":"Mannesse M. L.","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/356615a0","volume":"356","author":"Martinez C.","year":"1992","journal-title":"Nature"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1021\/ac049731y","volume":"76","author":"Kwon Y.","year":"2004","journal-title":"Anal. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.0705201104","volume":"104","author":"Bonasio R.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/nbt916","volume":"21","author":"Deyev S. M.","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.gene.2005.06.042","volume":"366","author":"Glinka E. M.","year":"2006","journal-title":"Gene"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biochi.2006.07.012","volume":"89","author":"Semenyuk E. G.","year":"2007","journal-title":"Biochimie"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1073\/pnas.1001142107","volume":"107","author":"Nikitin M. P.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1021\/bc0499477","volume":"15","author":"Backer M. V.","year":"2004","journal-title":"Bioconjugate Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/bc060037u","volume":"17","author":"Backer M. V.","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/protein\/gzg097","volume":"16","author":"Gaynutdinov T. I.","year":"2003","journal-title":"Protein Eng."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-1-60327-360-2_17","volume":"605","author":"Backer M. V.","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1477-3155-8-9","volume":"8","author":"Ferrari E.","year":"2010","journal-title":"J. Nanobiotechnol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/26412","volume":"395","author":"Sutton R. B.","year":"1998","journal-title":"Nature"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/415646a","volume":"415","author":"Hu K.","year":"2002","journal-title":"Nature"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"18197","DOI":"10.1073\/pnas.1007125107","volume":"107","author":"Darios F.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1016\/j.febslet.2005.03.089","volume":"579","author":"Baillie G. S.","year":"2005","journal-title":"FEBS Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nrm1527","volume":"5","author":"Wong W.","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/6663","volume":"6","author":"Newlon M. G.","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1016\/S0021-9258(18)98665-5","volume":"266","author":"Carr D. W.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0962-8924(99)01558-5","volume":"9","author":"Colledge M.","year":"1999","journal-title":"Trends Cell Biol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/emboj\/20.7.1651","volume":"20","author":"Newlon M. G.","year":"2001","journal-title":"EMBO J."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1073\/pnas.0330734100","volume":"100","author":"Alto N. M.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1021\/bc9001773","volume":"20","author":"Chang C. H.","year":"2009","journal-title":"Bioconjugate Chem."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1073\/pnas.0600982103","volume":"103","author":"Rossi E. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1158\/0008-5472.CAN-08-2033","volume":"68","author":"Rossi E. A.","year":"2008","journal-title":"Cancer Res."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1182\/blood-2008-10-187138","volume":"113","author":"Rossi E. A.","year":"2009","journal-title":"Blood"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1182\/blood-2009-06-228890","volume":"114","author":"Rossi E. A.","year":"2009","journal-title":"Blood"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1158\/0008-5472.CAN-05-0420","volume":"65","author":"Blumenthal R. D.","year":"2005","journal-title":"Cancer Res."},{"key":"ref65\/cit65","first-page":"3886S","volume":"9","author":"Rossi E. A.","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1073\/pnas.88.3.750","volume":"88","author":"Gegner J. A.","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.2967\/jnumed.110.079376","volume":"51","author":"Schoffelen R.","year":"2010","journal-title":"J. Nucl. Med."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/j.semnuclmed.2009.12.002","volume":"40","author":"Sharkey R. M.","year":"2010","journal-title":"Semin. Nucl. Med."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2967\/jnumed.108.060418","volume":"50","author":"McBride W. J.","year":"2009","journal-title":"J. Nucl. Med."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiol.2462070229","volume":"246","author":"Sharkey R. M.","year":"2008","journal-title":"Radiology"},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2967\/jnumed.110.083568","volume":"52","author":"Karacay H.","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1535-7163.MCT-09-0862","volume":"9","author":"Schoffelen R.","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/j.semnuclmed.2009.12.002","volume":"40","author":"Sharkey R. M.","year":"2010","journal-title":"Semin. Nucl. Med."},{"key":"ref74\/cit74","first-page":"1","volume":"25","author":"Sharkey R. M.","year":"2010","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.2967\/jnumed.109.067686","volume":"50","author":"Karacay H.","year":"2009","journal-title":"J. Nucl. Med."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2967\/jnumed.108.058602","volume":"50","author":"Sharkey R. M.","year":"2009","journal-title":"J. Nucl. Med."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1158\/0008-5472.CAN-08-0037","volume":"68","author":"Sharkey R. M.","year":"2008","journal-title":"Cancer Res."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1158\/0008-5472.CAN-08-0232","volume":"68","author":"Gold D. V.","year":"2008","journal-title":"Cancer Res."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiol.2462070229","volume":"246","author":"Sharkey R. M.","year":"2008","journal-title":"Radiology"},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2967\/jnumed.107.046185","volume":"49","author":"Goldenberg D. M.","year":"2008","journal-title":"J. Nucl. Med."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"5577s","DOI":"10.1158\/1078-0432.CCR-07-1087","volume":"13","author":"Sharkey R. M.","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1158\/1078-0432.CCR-03-0493","volume":"10","author":"Stein R.","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.molimm.2006.05.007","volume":"44","author":"Carnahan J.","year":"2007","journal-title":"Mol. Immunol."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood-2010-03-276857","volume":"116","author":"Gupta P.","year":"2010","journal-title":"Blood"},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1158\/0008-5472.CAN-10-2126","volume":"70","author":"Rossi E. A.","year":"2010","journal-title":"Cancer Res."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2009-10-250555","volume":"115","author":"Xuan C.","year":"2010","journal-title":"Blood"},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1182\/blood-2011-03-343145","volume":"118","author":"Rossi E. A.","year":"2011","journal-title":"Blood"},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1182\/blood-2009-06-228288","volume":"115","author":"Stein R.","year":"2010","journal-title":"Blood"},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1073\/pnas.2628038100","volume":"100","author":"Burns-Hamuro L. L.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/bi972701n","volume":"37","author":"Rustandi R. R.","year":"1998","journal-title":"Biochemistry"},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/78966","volume":"7","author":"Rose R. B.","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1074-5521(96)90146-5","volume":"3","author":"Fancy D. A.","year":"1996","journal-title":"Chem. Biol."},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1021\/bi9728046","volume":"37","author":"Brown K. C.","year":"1998","journal-title":"Biochemistry"},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1073\/pnas.96.11.6020","volume":"96","author":"Fancy D. A.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc2004999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T21:23:17Z","timestamp":1742073797000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc2004999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":94,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3,21]]}},"alternative-id":["10.1021\/bc2004999"],"URL":"https:\/\/doi.org\/10.1021\/bc2004999","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}