{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:32:41Z","timestamp":1760783561447},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2012,7,18]]},"DOI":"10.1021\/bc300239a","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:16:04Z","timestamp":1340064964000},"page":"1387-1395","source":"Crossref","is-referenced-by-count":37,"title":["Conformational Modulation of in Vitro Activity of Cyclic RGD Peptides via Aziridine Aldehyde-Driven Macrocyclization Chemistry"],"prefix":"10.1021","volume":"23","author":[{"given":"\u00c1ron","family":"Roxin","sequence":"first","affiliation":[{"name":"Ontario Cancer Institute and\rPrincess Margaret Hospital, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Ontario Cancer Institute and\rPrincess Margaret Hospital, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor C. G.","family":"Scully","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin H.","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei K.","family":"Yudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Ontario Cancer Institute and\rPrincess Margaret Hospital, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1021\/ja910544p","volume":"132","author":"Hili R.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"44","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"12257","DOI":"10.1002\/chem.201102096","volume":"17","author":"Rotstein B. H.","year":"2011","journal-title":"Chem.\u2014Eur. J."},{"issue":"31","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1039\/c2cc16027g","volume":"48","author":"Rotstein B. H.","year":"2012","journal-title":"Chem. Commun."},{"issue":"6","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/intimm\/8.6.927","volume":"8","author":"Zhang Q.-J.","year":"1996","journal-title":"Int. Immunol."},{"key":"ref5\/cit5","first-page":"113","volume":"47","author":"Zhang X.","year":"2006","journal-title":"J. Nucl. Med."},{"issue":"1","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1210\/en.2004-1481","volume":"147","author":"Ratcliffe K. E.","year":"2006","journal-title":"Endocrinology"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1021\/cr800323s","volume":"109","author":"Isidro-Llobet A.","year":"2009","journal-title":"Chem. Rev."},{"issue":"9","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/jps.2600610902","volume":"61","author":"Kopple K. D.","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/psc.795","volume":"13","author":"Harris K. M.","year":"2007","journal-title":"J. Pept. Sci."},{"issue":"2","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2225\/vol10-issue2-fulltext-13","volume":"10","author":"Guzm\u00e1n F.","year":"2007","journal-title":"Electron. J. Biotechnol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.7150\/thno\/v01p0102","volume":"1","author":"Ye T.","year":"2011","journal-title":"Theranostics"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.cellbio.12.1.697","volume":"12","author":"Ruoslahti E.","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"3","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1593\/neo.05769","volume":"8","author":"Montet X.","year":"2006","journal-title":"Neoplasia"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ddr.20265","volume":"69","author":"Liu Z.","year":"2008","journal-title":"Drug Dev. Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7150\/thno\/v01p0058","volume":"1","author":"Zhou Y.","year":"2011","journal-title":"Theranostics"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1021\/jm970832g","volume":"42","author":"Dechantsreiter M. A.","year":"1999","journal-title":"J. Med. Chem."},{"issue":"1","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11060-011-0650-1","volume":"106","author":"Gilbert M. R.","year":"2012","journal-title":"J. Neuro-Oncol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/annonc\/mdm140","volume":"18","author":"Hariharan S.","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/bc034038n","volume":"14","author":"Zhang M.","year":"2003","journal-title":"Bioconjugate Chem."},{"issue":"11","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/nprot.2010.127","volume":"5","author":"Rotstein B. H.","year":"2010","journal-title":"Nat. Prot."},{"issue":"4","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jcc.540110405","volume":"11","author":"Mohamadi F.","year":"1990","journal-title":"J. Comput. Chem."},{"issue":"19","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1073\/pnas.0408037102","volume":"102","author":"Jorgensen W. L.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/1097-0282(2000)56:4<275::AID-BIP10024>3.0.CO;2-E","volume":"56","author":"Tsui V.","year":"2001","journal-title":"Biopolymers"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/biomet\/57.1.97","volume":"57","author":"Hastings W. K.","year":"1970","journal-title":"Biometrika"},{"issue":"6","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1063\/1.1699114","volume":"21","author":"Metropolis N.","year":"1953","journal-title":"J. Chem. Phys."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1126\/science.1069040","volume":"296","author":"Xiong J. P.","year":"2002","journal-title":"Science"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/bc049763s","volume":"16","author":"Wang W.","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/bc900547d","volume":"21","author":"Liu Z.","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"ref29\/cit29","first-page":"155","volume":"1765","author":"R\u00fcegg C.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/psc.491","volume":"9","author":"Davies J. S.","year":"2003","journal-title":"J. Pept. Sci."},{"issue":"32","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"20232","DOI":"10.1016\/S0021-9258(17)31981-6","volume":"269","author":"Pfaff M.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.1021\/ja00096a034","volume":"116","author":"Geyer A.","year":"1994","journal-title":"J. Am. Chem. Soc."}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc300239a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T23:35:48Z","timestamp":1680651348000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc300239a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7,18]]}},"alternative-id":["10.1021\/bc300239a"],"URL":"https:\/\/doi.org\/10.1021\/bc300239a","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]}}}