{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:10:46Z","timestamp":1778778646561,"version":"3.51.4"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2013,3,20]]},"DOI":"10.1021\/bc300608h","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T21:22:56Z","timestamp":1361395376000},"page":"464-472","source":"Crossref","is-referenced-by-count":48,"title":["PEG-Farnesylthiosalicylate Conjugate as a Nanomicellar Carrier for Delivery of Paclitaxel"],"prefix":"10.1021","volume":"24","author":[{"given":"Xiaolan","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqin","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixian","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Venkataramanan","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna Beer","family":"Stolz","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics, \u2021Department of Pharmaceutical Sciences, School of Pharmacy, and \u00a7University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Department of Cell Biology and Physiology, \u22a5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/j.1875-9114.1997.tb03813.x","volume":"17","author":"Goldspiel B. R.","year":"1997","journal-title":"Pharmacotherapy"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jconrel.2006.11.014","volume":"117","author":"Xie Z.","year":"2007","journal-title":"J. Controlled Release"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/anie.200502113","volume":"45","author":"Haag R.","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","volume":"24","author":"Torchilin V. P.","year":"2007","journal-title":"Pharm. Res."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/15583720701455079","volume":"47","author":"Tong R.","year":"2007","journal-title":"Polym. Rev."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","volume":"65","author":"Maeda H.","year":"2000","journal-title":"J. Controlled Release"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0169-409X(98)00100-8","volume":"37","author":"Trubetskoy V. S.","year":"1999","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1021\/la001226i","volume":"17","author":"Riley T.","year":"2001","journal-title":"Langmuir"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/ja809086q","volume":"131","author":"Prencipe G.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1126\/science.8128245","volume":"263","author":"Gref R.","year":"1994","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.2174\/138161206779026245","volume":"12","author":"Croy S. R.","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biomaterials.2005.05.104","volume":"27","author":"Zhang Z.","year":"2006","journal-title":"Biomaterials"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s11095-008-9611-6","volume":"8","author":"Zhang Z.","year":"2008","journal-title":"Pharm. Res."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1016\/j.biomaterials.2010.03.070","volume":"21","author":"Prashant C.","year":"2010","journal-title":"Biomaterials"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/j.biomaterials.2011.02.022","volume":"32","author":"Mi Y.","year":"2011","journal-title":"Biomaterials"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1021\/bc3000468","volume":"23","author":"Huang Y. H.","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","unstructured":"Lu, J. Q., Huang, Y. H., Zhao, W. C., Marquez, R. T., Meng, X. J., Li, J., Gao, X., Wang, Z., Venkataramanan, R., and Li, S.PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers.Biomaterials 2012, in press.","DOI":"10.1016\/j.biomaterials.2012.10.073"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1021\/jm030420+","volume":"47","author":"Nikolovska-Coleska Z.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/bi972032d","volume":"37","author":"Haklai R.","year":"1998","journal-title":"Biochemistry"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1021\/jm00008a004","volume":"38","author":"Marciano D.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.drup.2005.11.002","volume":"8","author":"Blum R.","year":"2005","journal-title":"Drug Resistance Updates"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1357-4310(00)01789-5","volume":"6","author":"Kloog Y.","year":"2000","journal-title":"Mol. Med. Today"},{"key":"ref23\/cit23","first-page":"555","volume":"8","author":"Gana-Weisz M.","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0076-6879(07)00432-6","volume":"439","author":"Rotblat B.","year":"2008","journal-title":"Methods Enzymol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1038\/sj.onc.1204950","volume":"51","author":"Paz A.","year":"2001","journal-title":"Oncogene"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jps.22238","volume":"100","author":"Kraitzer A.","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/app.27450","volume":"107","author":"Zhang P.","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.colsurfb.2009.12.007","volume":"76","author":"Duan K.","year":"2010","journal-title":"Colloids Surf., B: Biointerfaces"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1016\/j.biomaterials.2011.05.050","volume":"32","author":"Li Y.","year":"2011","journal-title":"Biomaterials"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/bc1000033","volume":"21","author":"Luo J. T.","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1016\/j.biomaterials.2009.06.057","volume":"30","author":"Reul R.","year":"2009","journal-title":"Biomaterials"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1517\/13543784.8.12.2121","volume":"8","author":"Kloog Y.","year":"1998","journal-title":"Expert Opin. Invest. Drugs"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00280-007-0451-6","volume":"61","author":"Haklai R.","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref34\/cit34","first-page":"6387","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Res."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","volume":"41","author":"Maeda H.","year":"2001","journal-title":"Adv. Enzyme Regul."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00046364","volume":"9","author":"Jain R. K.","year":"1990","journal-title":"Cancer Metastasis Rev."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nnano.2011.166","volume":"6","author":"Cabral H.","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/01.ASN.0000057543.55318.8B","volume":"14","author":"Clarke H. C.","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/sj.onc.1202602","volume":"18","author":"Weisz B.","year":"1999","journal-title":"Oncogene"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"14019","DOI":"10.1073\/pnas.96.24.14019","volume":"96","author":"Jansen B.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc300608h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:20:22Z","timestamp":1714983622000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc300608h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,20]]}},"alternative-id":["10.1021\/bc300608h"],"URL":"https:\/\/doi.org\/10.1021\/bc300608h","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}