{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:36:22Z","timestamp":1790843782300,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Molecular identification of protein molecules surrounding nanoparticles (NPs) may provide useful information that influences NP clearance, biodistribution, and toxicity. Hence, nanoproteomics provides specific information about the environment that NPs interact with and can therefore report on the changes in protein distribution that occurs during tumorigenesis. Therefore, we hypothesized that characterization and identification of protein molecules that interact with 20 nm AuNPs from cancer and noncancer cells may provide mechanistic insights into the biology of tumor growth and metastasis and identify new therapeutic targets in ovarian cancer. Hence, in the present study, we systematically examined the interaction of the protein molecules with 20 nm AuNPs from cancer and noncancerous cell lysates. Time-resolved proteomic profiles of NP-protein complexes demonstrated electrostatic interaction to be the governing factor in the initial time-points which are dominated by further stabilization interaction at longer time-points as determined by ultraviolet\u2013visible spectroscopy (UV\u2013vis), dynamic light scattering (DLS), \u03b6-potential measurements, transmission electron microscopy (TEM), and tandem mass spectrometry (MS\/MS). Reduction in size, charge, and number of bound proteins were observed as the protein-NP complex stabilized over time. Interestingly, proteins related to mRNA processing were overwhelmingly represented on the NP-protein complex at all times. More importantly, comparative proteomic analyses revealed enrichment of a number of cancer-specific proteins on the AuNP surface. Network analyses of these proteins highlighted important hub nodes that could potentially be targeted for maximal therapeutic advantage in the treatment of ovarian cancer. The importance of this methodology and the biological significance of the network proteins were validated by a functional study of three hubs that exhibited variable connectivity, namely, PPA1, SMNDC1, and PI15. Western blot analysis revealed overexpression of these proteins in ovarian cancer cells when compared to normal cells. Silencing of PPA1, SMNDC1, and PI15 by the siRNA approach significantly inhibited proliferation of ovarian cancer cells and the effect correlated with the connectivity pattern obtained from our network analyses.<\/jats:p>","DOI":"10.1021\/bc500084f","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T13:24:34Z","timestamp":1400160274000},"page":"1078-1090","source":"Crossref","is-referenced-by-count":91,"title":["Understanding Protein\u2013Nanoparticle Interaction:\nA New Gateway to Disease Therapeutics"],"prefix":"10.1021","volume":"25","author":[{"given":"Karuna","family":"Giri","sequence":"first","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khader","family":"Shameer","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sounik","family":"Saha","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Science Center , , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir K.","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Science Center , , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirudh","family":"Sharma","sequence":"additional","affiliation":[{"name":"The University of Texas , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle R.","family":"Arvizo","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Madden","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Mccormick","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre A.","family":"Kocher","sequence":"additional","affiliation":[{"name":"Mayo Clinic , , , , ,","place":["Rochester, Minnesota, United States, 55905"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resham","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Science Center , , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyabrata","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Science Center , , , ,","place":["Oklahoma City, Oklahoma, United States, 73104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"2026090301350960500_cit1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ja107583h","article-title":"Physical-chemical aspects of protein\ncorona: relevance to in vitro and in vivo biological impacts of nanoparticles","volume":"133","author":"Monopoli","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026090301350960500_cit2","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/nn204951s","article-title":"Reversible\nversus irreversible binding of transferrin to polystyrene nanoparticles:\nSoft and hard corona","volume":"6","author":"Milani","year":"2012","journal-title":"ACS Nano"},{"key":"2026090301350960500_cit3","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1021\/ja910675v","article-title":"What the\ncell \u201csees\u201d in bionanoscience","volume":"132","author":"Walczyk","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026090301350960500_cit4","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nnano.2013.181","article-title":"Rapid formation of plasma protein corona critically affects nanoparticle\npathophysiology","volume":"8","author":"Tenzer","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"2026090301350960500_cit5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular coronas\nprovide the biological identity of nanosized materials","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"2026090301350960500_cit6","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.4161\/cc.8.22.9915","article-title":"Sniffing out\ncancer using \u2033chemical nose\u2033 sensors","volume":"8","author":"Rotello","year":"2009","journal-title":"Cell Cycle"},{"key":"2026090301350960500_cit7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/nn9011187","article-title":"Interaction of gold\nnanoparticles with common human blood proteins","volume":"4","author":"Lacerda","year":"2009","journal-title":"ACS Nano"},{"key":"2026090301350960500_cit8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nano.2008.08.001","article-title":"Interaction\nof colloidal gold nanoparticles with human blood: effects on particle\nsize and analysis of plasma protein binding profiles","volume":"5","author":"Dobrovolskaia","year":"2009","journal-title":"Nanomedicine"},{"key":"2026090301350960500_cit9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0378-5173(99)00432-9","article-title":"Nanoparticles with decreasing surface hydrophobicities:\ninfluence on plasma protein adsorption","volume":"196","author":"Gessner","year":"2000","journal-title":"Int.\nJ. Pharm."},{"key":"2026090301350960500_cit10","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ja107583h","article-title":"Physical-chemical aspects of protein\ncorona: relevance to in vitro and in vivo biological impacts of nanoparticles","volume":"133","author":"Monopoli","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026090301350960500_cit11","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1021\/nn201950e","article-title":"Nanoparticle size is a critical physicochemical\ndeterminant of the human blood plasma corona: a comprehensive quantitative\nproteomic analysis","volume":"5","author":"Tenzer","year":"2011","journal-title":"ACS Nano"},{"key":"2026090301350960500_cit12","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.0608582104","article-title":"Understanding\nthe nanoparticle-protein\ncorona using methods to quantify exchange rates and affinities of\nproteins for nanoparticles","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad.\nSci. U. S. 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Nanotechnol."},{"key":"2026090301350960500_cit15","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1021\/nn3052499","article-title":"Emerging techniques in proteomics\nfor probing nano\u2013bio interactions","volume":"6","author":"Lai","year":"2012","journal-title":"ACS\nNano"},{"key":"2026090301350960500_cit16","doi-asserted-by":"crossref","first-page":"e33650","DOI":"10.1371\/journal.pone.0033650","article-title":"Identifying\nNew therapeutic targets via modulation\nof protein corona formation by engineered nanoparticles","volume":"7","author":"Arvizo","year":"2012","journal-title":"PLoS One"},{"key":"2026090301350960500_cit17","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1039\/C1CS15166E","article-title":"Gold nanoparticles\nin biomedical applications: recent\nadvances and perspectives","volume":"41","author":"Dykman","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"2026090301350960500_cit18","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1158\/1078-0432.CCR-04-2482","article-title":"Antiangiogenic properties\nof gold nanoparticles","volume":"11","author":"Mukherjee","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"2026090301350960500_cit19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/art.22401","article-title":"Amelioration\nof collagen-induced arthritis in rats by nanogold","volume":"56","author":"Tsai","year":"2007","journal-title":"Arthritis Rheum."},{"key":"2026090301350960500_cit20","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1073\/pnas.1214547110","article-title":"Inhibition of tumor growth and metastasis\nby a self-therapeutic nanoparticle","volume":"110","author":"Arvizo","year":"2013","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"key":"2026090301350960500_cit21","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1039\/C3CS60338E","article-title":"Perturbation of physiological systems\nby nanoparticles","volume":"43","author":"Zhang","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"2026090301350960500_cit22","first-page":"239204","article-title":"Proteomics: challenges,\ntechniques and possibilities\nto overcome biological sample complexity","volume":"2009","author":"Chandramouli","year":"2009","journal-title":"Hum.\nGenomics. Proteomics."},{"key":"2026090301350960500_cit23","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1073\/pnas.160270797","article-title":"Evaluation\nof two-dimensional gel electrophoresis-based proteome analysis technology","volume":"97","author":"Gygi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090301350960500_cit24","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1038\/sj.onc.1206865","article-title":"Advantages and limitations of microarray\ntechnology in human cancer","volume":"22","author":"Russo","year":"2003","journal-title":"Oncogene"},{"key":"2026090301350960500_cit25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses\nof ovarian carcinoma","volume":"474","author":"Spellman","year":"2011","journal-title":"Nature"},{"key":"2026090301350960500_cit26","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1021\/nn901372t","article-title":"Time evolution\nof the nanoparticle protein corona","volume":"4","author":"Casals","year":"2010","journal-title":"ACS Nano"},{"key":"2026090301350960500_cit27","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1002\/smll.201101511","article-title":"Hardening\nof the nanoparticle\u2013protein corona in metal (Au, Ag) and oxide\n(Fe3O4, CoO, and CeO2) nanoparticles","volume":"7","author":"Casals","year":"2011","journal-title":"Small"},{"key":"2026090301350960500_cit28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/01442350050034180","article-title":"Shape and size dependence\nof radiative, non-radiative\nand photothermal properties of gold nanocrystals","volume":"19","author":"Link","year":"2000","journal-title":"Int. Rev. Phys. Chem."},{"key":"2026090301350960500_cit29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12575-009-9008-x","article-title":"Size and\nshape of protein molecules at the nanometer level determined by sedimentation,\ngel filtration, and electron microscopy","volume":"11","author":"Erickson","year":"2009","journal-title":"Biol.\nProced. Online"},{"key":"2026090301350960500_cit30","article-title":"Pretreatment with chemotherapeutics for\nenhanced nanoparticles accumulation in tumor: the potential role of\nG2 cycle retention effect","volume":"4","author":"Gao","year":"2014","journal-title":"Sci. Rep."},{"key":"2026090301350960500_cit31","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1021\/la050588t","article-title":"Probing BSA\nbinding to citrate-coated gold nanoparticles and surfaces","volume":"21","author":"Brewer","year":"2005","journal-title":"Langmuir"},{"key":"2026090301350960500_cit32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.biophys.31.082901.134314","article-title":"The natural history of protein domains","volume":"31","author":"Ponting","year":"2002","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"2026090301350960500_cit33","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1111\/j.1742-4658.2005.04653.x","article-title":"The RNA recognition motif, a plastic\nRNA-binding platform to regulate post-transcriptional gene expression","volume":"272","author":"Maris","year":"2005","journal-title":"FEBS J."},{"key":"2026090301350960500_cit34","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1039\/c2cs15355f","article-title":"Intrinsic therapeutic applications of noble metal nanoparticles:\npast, present and future","volume":"41","author":"Arvizo","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"2026090301350960500_cit35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbapap.2008.10.016","article-title":"Protein\naggregation kinetics, mechanism,\nand curve-fitting: A review of the literature","volume":"1794","author":"Morris","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2026090301350960500_cit36","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bar042","article-title":"3DSwap: curated knowledgebase of proteins involved in 3D domain swapping","volume":"2011","author":"Shameer","year":"2011","journal-title":"Database"},{"key":"2026090301350960500_cit37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0968-0004(01)01938-7","article-title":"Macromolecular\ncrowding: obvious but underappreciated","volume":"26","author":"Ellis","year":"2001","journal-title":"Trends\nBiochem. Sci."},{"key":"2026090301350960500_cit38","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nmeth.2212","article-title":"A travel guide to Cytoscape plugins","volume":"9","author":"Saito","year":"2012","journal-title":"Nat. Meth."},{"key":"2026090301350960500_cit39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35075138","article-title":"Lethality and centrality\nin protein networks","volume":"411","author":"Jeong","year":"2001","journal-title":"Nature"},{"key":"2026090301350960500_cit40","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ng1856","article-title":"Multiple knockout\nanalysis\nof genetic robustness in the yeast metabolic network","volume":"38","author":"Deutscher","year":"2006","journal-title":"Nat. Genet."},{"key":"2026090301350960500_cit41","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1093\/nar\/gkr454","article-title":"The human DEK oncogene\nregulates DNA damage response signaling and repair","volume":"39","author":"Kavanaugh","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2026090301350960500_cit42","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s13277-012-0449-5","article-title":"Pyrophosphatase\noverexpression is associated with cell migration, invasion, and poor\nprognosis in gastric cancer","volume":"33","author":"Jeong","year":"2012","journal-title":"Tumour Biol."},{"key":"2026090301350960500_cit43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/37144","article-title":"Synergistic\nanti-apoptotic activity between Bcl-2 and\nSMN implicated in spinal muscular atrophy","volume":"390","author":"Iwahashi","year":"1997","journal-title":"Nature"},{"key":"2026090301350960500_cit44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/10408363.2013.865701","article-title":"Function and clinical\nrelevance of\nkallikrein-related peptidases and other serine proteases in gynecological\ncancers","volume":"51","author":"Dorn","year":"2014","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"2026090301350960500_cit45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/oxfordjournals.jbchem.a021244","article-title":"Purification\nand identification of\na novel and four known serine proteinase inhibitors secreted by human\nglioblastoma cells","volume":"119","author":"Koshikawa","year":"1996","journal-title":"J. Biochem."},{"key":"2026090301350960500_cit46","doi-asserted-by":"crossref","first-page":"43ra55","DOI":"10.1126\/scitranslmed.3001065","article-title":"Pathway-based identification of biomarkers\nfor targeted therapeutics: personalized oncology with PI3K pathway\ninhibitors","volume":"2","author":"Andersen","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"2026090301350960500_cit47","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/ncponc1187","article-title":"Strategies\nfor discovering novel cancer biomarkers\nthrough utilization of emerging technologies","volume":"5","author":"Kulasingam","year":"2008","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"2026090301350960500_cit48","doi-asserted-by":"crossref","first-page":"e38061","DOI":"10.1371\/journal.pone.0038061","article-title":"Differences in immunoglobulin\nlight chain species found in urinary exosomes in light chain amyloidosis\n(AL)","volume":"7","author":"Ramirez-Alvarado","year":"2012","journal-title":"PLoS One"},{"key":"2026090301350960500_cit49","first-page":"571","volume-title":"Protein Identification\nand Analysis Tools on the ExPASy Server","author":"Gasteiger","year":"2005"},{"key":"2026090301350960500_cit50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools:\npaths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2026090301350960500_cit51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis\nof large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2008","journal-title":"Nat. Protoc."},{"key":"2026090301350960500_cit52","doi-asserted-by":"crossref","first-page":"D646","DOI":"10.1093\/nar\/gkm936","article-title":"CORUM: the comprehensive resource\nof mammalian protein complexes","volume":"36","author":"Ruepp","year":"2008","journal-title":"Nucleic Acids\nRes."},{"key":"2026090301350960500_cit53","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/gb-2008-9-s1-s1","article-title":"A race though the maze\nof genomic evidence","volume":"9","author":"Hughes","year":"2008","journal-title":"Genome Biol."},{"key":"2026090301350960500_cit54","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models\nof biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome\nRes."},{"key":"2026090301350960500_cit55","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nprot.2012.004","article-title":"Topological analysis\nand interactive visualization of biological networks and protein structures","volume":"7","author":"Doncheva","year":"2012","journal-title":"Nat. Protoc."},{"key":"2026090301350960500_cit56","doi-asserted-by":"crossref","first-page":"e79167","DOI":"10.1371\/journal.pone.0079167","article-title":"Cystathionine beta-synthase (CBS) contributes to advanced ovarian\ncancer progression and drug resistance","volume":"8","author":"Bhattacharyya","year":"2013","journal-title":"PLoS\nOne"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc500084f","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bcches\/article-pdf\/25\/6\/1078\/15671783\/bc500084f.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bcches\/article-pdf\/25\/6\/1078\/15671783\/bc500084f.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:35:24Z","timestamp":1788413724000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bcches\/article\/25\/6\/1078\/1475214\/Understanding-Protein-Nanoparticle-Interaction-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,5,15]]},"published-print":{"date-parts":[[2014,6,18]]}},"URL":"https:\/\/doi.org\/10.1021\/bc500084f","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}