{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:12:19Z","timestamp":1791130339677,"version":"4.1.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2008,1,1]]},"DOI":"10.1021\/bc700196q","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T11:01:11Z","timestamp":1195124471000},"page":"315-321","source":"Crossref","is-referenced-by-count":17,"title":["Ligand-Modified Aminobisphosphonate for Linking Proteins to Hydroxyapatite and Bone Surface"],"prefix":"10.1021","volume":"19","author":[{"given":"Robin S.","family":"Ehrick","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, and Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Capaccio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, and Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Puleo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, and Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas G.","family":"Bachas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, and Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,11,15]]},"reference":[{"key":"ref1\/ref1_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.289.5484.1497","volume":"289","author":"Kiberstis P.","year":"2000","journal-title":"Science"},{"key":"ref2\/ref2_1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","volume":"289","author":"Ducy P.","year":"2000","journal-title":"Science"},{"key":"ref3\/ref3_1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","volume":"289","author":"Teitelbaum S. L.","year":"2000","journal-title":"Science"},{"key":"ref4\/ref4_1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","volume":"289","author":"Rodan G. A.","year":"2000","journal-title":"Science"},{"key":"ref5\/ref5_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1056\/NEJMe068007","volume":"354","author":"Finkelstein J. S.","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref6\/ref6_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJMoa055218","volume":"354","author":"Jackson R. D.","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref7\/ref7_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/jama.288.3.366","volume":"288","author":"Fletcher S. W.","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"ref8\/ref8_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"Rossouw J. E.","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"ref9\/ref9_1","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","volume":"289","author":"Shumaker S. A.","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"ref10\/ref10_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/BF02555919","volume":"47","author":"Cumming R. G.","year":"1990","journal-title":"Calcif. Tissue Int."},{"key":"ref11\/ref11_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/er.2001-7002","volume":"23","author":"Shea B.","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref12\/ref12_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.8480174","volume":"260","author":"Horowitz M. C.","year":"1993","journal-title":"Science"},{"key":"ref13\/ref13_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1172\/JCI4682","volume":"103","author":"Sunyer T.","year":"1999","journal-title":"J. Clin. Invest."},{"key":"ref14\/ref14_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","volume":"18","author":"Lin J. H.","year":"1996","journal-title":"Bone"},{"key":"ref15\/ref15_1","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1021\/ed081p1406","volume":"81","author":"Williams K. R.","year":"2004","journal-title":"J. Chem. Educ."},{"key":"ref16\/ref16_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11914-003-0008-5","volume":"1","author":"Reszka A. A.","year":"2003","journal-title":"Curr. Osteoporosis Rep."},{"key":"ref17\/ref17_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/1566524023362104","volume":"2","author":"Rodan G. A.","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"ref18\/ref18_1","doi-asserted-by":"crossref","first-page":"34967","DOI":"10.1074\/jbc.274.49.34967","volume":"274","author":"Reszka A. A.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref19\/ref19_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.addr.2004.12.014","volume":"57","author":"Bagi C. M.","year":"2005","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref20\/ref20_1","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/jps.20186","volume":"93","author":"Bansal G.","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"ref21\/ref21_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1359\/jbmr.1997.12.9.1358","volume":"12","author":"Frith J. C.","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"ref22\/ref22_1","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.jorganchem.2004.09.069","volume":"690","author":"Green J. R.","year":"2004","journal-title":"J. Organomet. Chem."},{"key":"ref23\/ref23_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S8756-3282(01)00615-9","volume":"29","author":"Halasy-Nagy J. M.","year":"2001","journal-title":"Bone"},{"key":"ref24\/ref24_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1634\/theoncologist.9-90004-38","volume":"9","author":"Lipton A.","year":"2004","journal-title":"The Oncologist"},{"key":"ref25\/ref25_1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1023\/A:1024445903306","volume":"20","author":"Gittens S. A.","year":"2003","journal-title":"Pharm. Res."},{"key":"ref26\/ref26_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/bp990154m","volume":"16","author":"Uluda\u01e7 H.","year":"2000","journal-title":"Biotechnol. Prog."},{"key":"ref27\/ref27_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jconrel.2004.05.001","volume":"98","author":"Gittens S. A.","year":"2004","journal-title":"J. Controlled Release"},{"key":"ref28\/ref28_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1021\/bp000066y","volume":"16","author":"Uluda\u01e7 H.","year":"2000","journal-title":"Biotechnol. Prog."},{"key":"ref29\/ref29_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1021\/bp0200447","volume":"18","author":"Uluda\u01e7 H.","year":"2002","journal-title":"Biotechnol. Prog."},{"key":"ref30\/ref30_1","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1080\/00397919608003560","volume":"26","author":"Kantoci D.","year":"1996","journal-title":"Synth. Commun."},{"key":"ref31\/ref31_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0003-2670(00)80668-6","volume":"246","author":"Przyjazny A.","year":"1991","journal-title":"Anal. Chim. Acta"},{"key":"ref32\/ref32_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","volume":"38","author":"Nancollas G. H.","year":"2006","journal-title":"Bone"},{"key":"ref33\/ref33_1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2174\/1381612023393585","volume":"8","author":"Uluda\u01e7 H.","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"ref34\/ref34_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/B512310K","volume":"36","author":"Zhang S.","year":"2007","journal-title":"Chem. Soc. Rev."}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc700196q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:50:45Z","timestamp":1678953045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc700196q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,15]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1,1]]}},"alternative-id":["10.1021\/bc700196q"],"URL":"https:\/\/doi.org\/10.1021\/bc700196q","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,15]]}}}