{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:58:37Z","timestamp":1791129517436,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2009,4,15]]},"DOI":"10.1021\/bc8004683","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T16:36:02Z","timestamp":1236616562000},"page":"760-767","source":"Crossref","is-referenced-by-count":71,"title":["Development of a Dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Contrast Agent: Synthesis, Toxicity (in Vitro) and Relaxivity (in Vitro, in Vivo) Studies"],"prefix":"10.1021","volume":"20","author":[{"given":"Annabelle","family":"Bertin","sequence":"first","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg, UMR CNRS\/ULP 7504, 23 rue du L\u0153ss BP 43, 67034 Strasbourg Cedex 2, France, Laboratoire d\u2019Imagerie et de Neurosciences Cognitives, UMR CNRS\/ULP 7191, 12 rue Goethe, 67000 Strasbourg, France, and siRNA Therapeutics, NIBR Biologics Center, Novartis Institutes for Biomedical Research, Inc., 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Steibel","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg, UMR CNRS\/ULP 7504, 23 rue du L\u0153ss BP 43, 67034 Strasbourg Cedex 2, France, Laboratoire d\u2019Imagerie et de Neurosciences Cognitives, UMR CNRS\/ULP 7191, 12 rue Goethe, 67000 Strasbourg, France, and siRNA Therapeutics, NIBR Biologics Center, Novartis Institutes for Biomedical Research, Inc., 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Isabelle","family":"Michou-Gallani","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg, UMR CNRS\/ULP 7504, 23 rue du L\u0153ss BP 43, 67034 Strasbourg Cedex 2, France, Laboratoire d\u2019Imagerie et de Neurosciences Cognitives, UMR CNRS\/ULP 7191, 12 rue Goethe, 67000 Strasbourg, France, and siRNA Therapeutics, NIBR Biologics Center, Novartis Institutes for Biomedical Research, Inc., 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Gallani","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg, UMR CNRS\/ULP 7504, 23 rue du L\u0153ss BP 43, 67034 Strasbourg Cedex 2, France, Laboratoire d\u2019Imagerie et de Neurosciences Cognitives, UMR CNRS\/ULP 7191, 12 rue Goethe, 67000 Strasbourg, France, and siRNA Therapeutics, NIBR Biologics Center, Novartis Institutes for Biomedical Research, Inc., 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Felder-Flesch","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg, UMR CNRS\/ULP 7504, 23 rue du L\u0153ss BP 43, 67034 Strasbourg Cedex 2, France, Laboratoire d\u2019Imagerie et de Neurosciences Cognitives, UMR CNRS\/ULP 7191, 12 rue Goethe, 67000 Strasbourg, France, and siRNA Therapeutics, NIBR Biologics Center, Novartis Institutes for Biomedical Research, Inc., 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,3,9]]},"reference":[{"key":"ref1\/cit1","unstructured":"Mansson, S., Bjornerud, A. in, Merbach, A. E., and Toth, E., Eds. (2001) The Chemistry of contrast agents in medical magnetic resonance imaging, pp1\u221244,Wiley,New York."},{"key":"ref2\/cit2","first-page":"1018","volume":"41","author":"Aime S.","year":"2002","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"8940","DOI":"10.1021\/ja001426g","volume":"122","author":"Reynolds C. H.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/nbm.959","volume":"18","author":"Rodriguez E.","year":"2005","journal-title":"NMR Biomed."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/00004424-199712000-00004","volume":"32","author":"Parmelee D. J.","year":"2001","journal-title":"Invest. Radiol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0730-725X(01)00380-0","volume":"19","author":"Lokling K. E.","year":"2001","journal-title":"Magn. Reson. Imaging"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/(SICI)1522-2586(199907)10:1<80::AID-JMRI11>3.0.CO;2-S","volume":"10","author":"Wolfgang S.","year":"1999","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/nbm.1015","volume":"19","author":"Langereis S.","year":"2006","journal-title":"NMR Biomed."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jinorgbio.2005.12.003","volume":"100","author":"Aime S.","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.carbon.2005.08.016","volume":"44","author":"Shu C. Y.","year":"2006","journal-title":"Carbon"},{"key":"ref11\/cit11","first-page":"206","author":"Comet M.","year":"1998","journal-title":"In Presses Universitaires de Grenoble"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/cr068445e","volume":"108","author":"Laurent S.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jinorgbio.2007.04.003","volume":"101","author":"Li Z.","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/anie.200690172","volume":"46","author":"Na H. B.","year":"2007","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"7","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nn1477","volume":"8","author":"Yu X.","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/nbm.940","volume":"17","author":"Koretsky A. P.","year":"2004","journal-title":"NMR Biomed"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1148\/radiology.178.1.1898538","volume":"178","author":"Elizondo G.","year":"1991","journal-title":"Radiology"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1039\/b509843b","volume":"5","author":"Hayek A.","year":"2006","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/ejic.200601170","author":"Laurent S.","year":"2007","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1126\/science.290.5490.307","volume":"290","author":"Simeonov A.","year":"2000","journal-title":"Science"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/PL00012496","volume":"59","author":"Avdeef A.","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/ajplegacy.1975.229.4.1003","volume":"229","author":"Langer G. A.","year":"1975","journal-title":"Am. J. Physiol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/0003-9861(89)90327-5","volume":"268","author":"Haworth R. A.","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/B978-0-12-225401-7.50093-X","volume-title":"Frontiers of Biological Energetics","volume":"1","author":"Lauterbur P. C.","year":"1978"},{"key":"ref25\/cit25","first-page":"123","volume":"16","author":"Mamourian A. C.","year":"1984","journal-title":"Physiol. Chem. Phys. Med. NMR"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/mrm.1910010310","volume":"1","author":"Kang Y. S.","year":"1984","journal-title":"Magn. Res. Med."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/(SICI)1522-2586(199907)10:1<15::AID-JMRI3>3.0.CO;2-X","volume":"10","author":"Small W. C.","year":"1999","journal-title":"J. Magn. Res. Imaging"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/nbm.931","volume":"17","author":"Crossgrove J.","year":"2004","journal-title":"NMR Biomed."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2214\/ajr.141.1.193","volume":"141","author":"Wolf G. L.","year":"1983","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mrm.1910350104","volume":"35","author":"Gallez B.","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/1522-2586(200007)12:1<186::AID-JMRI21>3.0.CO;2-2","volume":"12","author":"Federle M. P.","year":"2000","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/A827019Z","volume":"27","author":"Aime S.","year":"1998","journal-title":"Chem. Soc. Rev."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/mrm.1910380415","volume":"38","author":"Vander Elst L.","year":"1997","journal-title":"Magn. Res. Med."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/(SICI)1099-0682(199911)1999:11<1949::AID-EJIC1949>3.0.CO;2-0","author":"Muller R. N.","year":"1999","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/mrm.1910380305","volume":"38","author":"Lin Y. J.","year":"1997","journal-title":"Magn. Reson. Med."}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc8004683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:42:16Z","timestamp":1679546536000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc8004683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,9]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4,15]]}},"alternative-id":["10.1021\/bc8004683"],"URL":"https:\/\/doi.org\/10.1021\/bc8004683","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,9]]}}}