{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:29:32Z","timestamp":1791304172608,"version":"4.3.1"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2001,7,1]]},"DOI":"10.1021\/bi002614m","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:39:39Z","timestamp":1027658379000},"page":"8990-8996","source":"Crossref","is-referenced-by-count":77,"title":["Evidence for Isoniazid-Dependent Free Radical Generation Catalyzed by <i>Mycobacterium tuberculosi<\/i>s KatG and the Isoniazid-Resistant Mutant KatG(S315T)"],"prefix":"10.1021","volume":"40","author":[{"given":"Nancy L.","family":"Wengenack","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rusnak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic, Rochester, Minnesota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2001,6,30]]},"reference":[{"key":"bi002614mb00001\/bi002614mb00001_1","volume-title":"Little","author":"Ryan F.","year":"1993"},{"key":"bi002614mb00002\/bi002614mb00002_1","volume-title":"in Tuberculosis. Pathogenesis, Protection, and Control","author":"Daniel T. M.","year":"1994"},{"key":"bi002614mb00003\/bi002614mb00003_1","volume-title":"in World Health Report","author":"World Health Organization","year":"1999"},{"key":"bi002614mb00004\/bi002614mb00004_1","volume":"69","author":"Middlebrook G.","year":"1954","journal-title":"Am. Rev. Tuberc."},{"key":"bi002614mb00005\/bi002614mb00005_1","volume":"149","author":"Gayathri Devi B.","year":"1975","journal-title":"Biochem. J."},{"key":"bi002614mb00006\/bi002614mb00006_1","volume-title":"Nature 358, 591\u2212593","author":"Zhang Y.","year":"1992"},{"key":"bi002614mb00007\/bi002614mb00007_1","volume-title":"Mol. Microbiol. 8, 521\u2212524","author":"Zhang Y.","year":"1993"},{"key":"bi002614mb00008\/bi002614mb00008_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.5.2834","volume":"272","author":"Johnsson K.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi002614mb00009\/bi002614mb00009_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja00095a063","volume":"116","author":"Johnsson K.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"bi002614mb00010\/bi002614mb00010_1","volume-title":"Mol. Microbiol. 15, 235\u2212245","author":"Heym B.","year":"1995"},{"key":"bi002614mb00011\/bi002614mb00011_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.38.22290","volume":"270","author":"Marcinkeviciene J. A.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi002614mb00012\/bi002614mb00012_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja992590a","volume":"121","author":"Wengenack N. L.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"bi002614mb00013\/bi002614mb00013_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3380753","volume":"338","author":"Saint-Joanis B.","year":"1999","journal-title":"Biochem. J."},{"key":"bi002614mb00014\/bi002614mb00014_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.14.8867","volume":"272","author":"Magliozzo R. S.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi002614mb00015\/bi002614mb00015_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja9639731","volume":"119","author":"Zabinski R. F.","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"bi002614mb00016\/bi002614mb00016_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja962047j","volume":"118","author":"Magliozzo R. S.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"bi002614mb00017\/bi002614mb00017_1","volume-title":"Biochem. Biophys. Res. Commun. 256, 485\u2212487","author":"Wengenack N. L.","year":"1999"},{"key":"bi002614mb00018\/bi002614mb00018_1","volume-title":"Science 263, 227\u2212230","author":"Banerjee A.","year":"1994"},{"key":"bi002614mb00019\/bi002614mb00019_1","doi-asserted-by":"crossref","DOI":"10.1128\/JB.182.14.4059-4067.2000","volume":"182","author":"Vilcheze C.","year":"2000","journal-title":"J. Bacteriol."},{"key":"bi002614mb00020\/bi002614mb00020_1","doi-asserted-by":"crossref","unstructured":"Mdluli, K., Slayden, R. A., Zhu, Y., Ramaswamy, S., Pan, X., Mead, D., Crane, D. D., Musser, J. M., and Barry, C. E., III (1998)Science280, 1607\u22121610.","DOI":"10.1126\/science.280.5369.1607"},{"key":"bi002614mb00021\/bi002614mb00021_1","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/173.1.196","volume":"173","author":"Musser J. M.","year":"1996","journal-title":"J. Infect. Dis."},{"key":"bi002614mb00022\/bi002614mb00022_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1054\/tuld.1998.0002","volume":"79","author":"Ramaswamy S.","year":"1998","journal-title":"Tuberc. Lung Dis."},{"key":"bi002614mb00023\/bi002614mb00023_1","volume-title":"Mol. Microbiol. 22, 583\u2212592","author":"Rouse D. A.","year":"1996"},{"key":"bi002614mb00024\/bi002614mb00024_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)33119-3","volume":"258","author":"Sinha B. K.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"bi002614mb00025\/bi002614mb00025_1","volume-title":"Antimicrob. Agents Chemother. 27, 408\u2212412","author":"Shoeb H. A.","year":"1985"},{"key":"bi002614mb00026\/bi002614mb00026_1","volume-title":"Antimicrob. Agents Chemother. 27, 404\u2212407","author":"Shoeb H. A.","year":"1985"},{"key":"bi002614mb00027\/bi002614mb00027_1","volume-title":"Antimicrob. Agents Chemother. 35, 1035\u22121039","author":"Quemard A.","year":"1991"},{"key":"bi002614mb00028\/bi002614mb00028_1","volume-title":"Arzneim.-Forsch. 18, 362\u2212367","author":"Seydel V. J. K.","year":"1968"},{"key":"bi002614mb00029\/bi002614mb00029_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00226a007","volume":"19","author":"Seydel J. K.","year":"1976","journal-title":"J. Med. Chem."},{"key":"bi002614mb00030\/bi002614mb00030_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja9918674","volume":"121","author":"Todorovi\u0107 S.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"bi002614mb00031\/bi002614mb00031_1","doi-asserted-by":"crossref","DOI":"10.1086\/514096","volume":"176","author":"Wengenack N. L.","year":"1997","journal-title":"J. Infect. Dis."},{"key":"bi002614mb00032\/bi002614mb00032_1","volume-title":"Anal. Biochem. 72, 248\u2212254","author":"Bradford M. M.","year":"1976"},{"key":"bi002614mb00033\/bi002614mb00033_1","volume-title":"in Electron Paramagnetic Resonance:\u2009 Elementary Theory and Practical Applications","author":"Weil J. A.","year":"1994"},{"key":"bi002614mb00034\/bi002614mb00034_1","volume":"39","author":"Li A. S. W.","year":"1988","journal-title":"J. Magn. Reson."},{"key":"bi002614mb00035\/bi002614mb00035_1","volume-title":"Antimicrob. Agents Chemother. 27, 399\u2212403","author":"Shoeb H. A.","year":"1985"},{"key":"bi002614mb00036\/bi002614mb00036_1","volume-title":"Environ. Health Perspect. 64, 179\u2212184","author":"Kalyanaraman B.","year":"1985"},{"key":"bi002614mb00037\/bi002614mb00037_1","volume":"264","author":"Ator M. A.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"bi002614mn00001\/bi002614mn00001_1","volume-title":"acyl carrier protein","author":"Abbreviations ACP"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi002614m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:55:41Z","timestamp":1678078541000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi002614m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,30]]},"references-count":38,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["10.1021\/bi002614m"],"URL":"https:\/\/doi.org\/10.1021\/bi002614m","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,30]]}}}